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A kind of 820 strains of chicken infectious bronchitis virus and its application

A technology for bronchitis and chicken infectivity, applied in the field of chicken infectious bronchitis virus, can solve the problems of inapplicable challenge test and weak virus toxicity, and achieve strong pathogenicity, broad application prospects, morbidity and death strong effect

Inactive Publication Date: 2017-03-08
INST OF ANIMAL SCI & VETERINARY MEDICINE SHANDONG ACADEMY OF AGRI SCI
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Problems solved by technology

[0004] In order to solve the problem that the above existing chicken infectious bronchitis virus screened out in China is not highly toxic and not suitable for challenge experiments, the present invention provides a strain of chicken infectious bronchitis virus with strong pathogenicity and can cause typical symptoms 820 ( infectious bronchitis virus ) strain

Method used

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Embodiment

[0021] Chicken infectious bronchitis virus 820 strain is a wild strain isolated from a chicken farm in Shandong in 2012. It was obtained through SPF chicken embryo value-added, and the incidence rate in animal pathogenic tests was over 80%, which is a strong virus strain. IBV is round to polygonal indeterminate. The virus has an envelope with a diameter of 120 nm. There are rod-shaped fibrils on the surface, about 20 nm long. The nucleocapsid protein (RNP) released by the spontaneous disintegration of virus particles can be observed by projection technology. , core), in most cases the RNP that can be observed is a cord with a diameter of 1-2 nm, but occasionally a coiled structure with a diameter of 10-15 nm can be seen. The deposit number of the Microbiology Center is CGMCC No.9571.

[0022] 1.1 Animal pathogenicity test

[0023] In order to better screen for suitable challenge strains for the evaluation of vaccine immunity, we screened 3 strains (337 strains, 369 strains, ...

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Abstract

The invention relates to the field of avian infectious bronchitis virulent strain models in veterinarian biological products, in particular to an avian infectious bronchitis 820 strain of which the preservation serial number is CGMCC No.9571 and application of the avian infectious bronchitis 820 strain in the effect test of an avian infectious bronchitis vaccine. The avian infectious bronchitis virus 820 strain has high morbidity rate and high dead rate in inoculated chicken flock, has toxic substance counteracting effect close to clinic morbidity and lethal levels, has the capability of simulating clinic virus morbidity, and can effectively evaluate the protection level of the vaccine, thereby reducing economic losses caused by the disease. The avian infectious bronchitis 820 strain has wide application prospects in vaccine evaluation field.

Description

technical field [0001] The invention relates to the technical field of avian infectious bronchitis virus, in particular to a chicken infectious bronchitis virus 820 strain, and also relates to the application of the chicken infectious bronchitis virus 820 strain. Background technique [0002] Chicken infectious bronchitis (infectious bronchitis, IB) is an acute, highly contagious viral respiratory disease of chickens caused by infectious bronchitis virus (IBV), characterized by tracheal rales, cough and It is characterized by sneezing. The disease mainly causes chicken weight gain and reduced feed remuneration in broilers. After IBV damages the respiratory tract, it can also cause secondary bacterial infections, and the mortality rate of chicks can be as high as 30%. Some strains of IB can cause severe nephrotic lesions. IBV can also replicate in the oviduct, and the egg production of adult chickens will decrease by 10%, 50% or more after infection. At the same time, the n...

Claims

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Application Information

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IPC IPC(8): C12N7/00C12R1/93
Inventor 黄庆华许传田胡北侠杨少华张秀美张琳
Owner INST OF ANIMAL SCI & VETERINARY MEDICINE SHANDONG ACADEMY OF AGRI SCI
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