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Pharmaceutical composition and preparation method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems such as the pharmacological activity of the root vegetable extract that has not been seen yet, and achieve the effect of simple preparation method, definite curative effect and good safety

Inactive Publication Date: 2015-01-14
SICHUAN TIANSHOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But so far, there have been no reports of the pharmacological activities of the extract of the root vegetable, which has the functions of protecting the liver, reducing enzymes, promoting gallbladder and reducing jaundice, immune regulation, anti-HBV virus, and inhibiting precancerous lesions.

Method used

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  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof
  • Pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 1 Kg of the root vegetable and put it in an extraction tank, add water and decoct three times (the amount of water added each time is 10 Kg, and the decoction time is 2 hours each time), and filter through a 100-mesh sieve to obtain the filtrate.

[0036] Send the filtrate to a three-effect energy-saving concentrator to concentrate to a clear paste with a relative density of 1.16-1.18 (measured at 60-65°C), and let it cool. The concentration temperature is 50-90°C, and the vacuum degree is -0.01 - -0.06Mpa.

[0037] Add dehydrated ethanol to the clear paste after cooling to make the alcohol content reach 60%, stir evenly, leave standstill, filter with 100 mesh sieves after 24 hours to obtain filtrate and precipitate, precipitate is washed with 6Kg60% ethanol, combine washing liquid and filtrate ( Hereinafter referred to as the mixed solution), let it stand for 4 hours.

[0038] Concentrate the mixed solution under reduced pressure to a clear paste with a relative...

Embodiment 2

[0045] The pharmaceutical composition prepared in Example 1 is carried out in animal experiments, and it is found that the pharmaceutical composition can significantly reduce CCl 4 Serum ALT of poisoned rats decreased CCl 4 The residence time of mouse serum BSP has obvious hepatoprotective effect.

Embodiment 3

[0047] The choleretic test of rats with the pharmaceutical composition prepared in Example 1 shows that it can obviously promote bile secretion and reduce total bilirubin in blood.

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PUM

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Abstract

The invention discloses a pharmaceutical composition and a preparation method thereof. The pharmaceutical composition comprises quercetin, gallic acid, quercetin-3-0-alpha-L-rhamnopyranoside, pinocembrin-7-0-beta-D-glucopyranose and 2,6-dihydroxyacetophenone-4-0-D-glucopyranose. Compared with the existing drug, the pharmaceutical composition can protect liver and reduce transaminase and relieve the jaundice symptoms, has definite therapeutic effects and has good safety.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof. Background technique [0002] Root vegetable is another name for Lysimachia clethroides Duby, also known as tiger tail vegetable. Up to 90cm. Stem erect, reddish purple, glabrous, slightly branched at upper part. Alternate single leaves with very short stalks; leaves lanceolate, 3-11cm long, with finely serrated edges, glabrous on both sides. Raceme terminal, flower axis with glandular hairs; calyx broadly bell-shaped and 5-lobed; no petals; stamens 10; pistils 5, basally healed, light yellow when flowering, and turn green after flowering. Capsule reddish brown, with short beak. Seeds numerous, small, yellow-white. The flowering period is July-August, and the fruiting period is September. [0003] The folks use the whole herb of root vegetables as medicine, which is recorded in the "Dictionary of Traditional Chinese Medicine" and "Sichuan Traditional Chinese ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61P37/02A61P35/00A61P31/20
CPCA61K36/185A61K9/1611A61K2236/331A61K2236/53
Inventor 淦吉银张勇
Owner SICHUAN TIANSHOU PHARMA
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