A kind of production method of saline heparin sodium

Abstract

The invention discloses a production method of brine heparin sodium. The production method comprises the following five steps: preparation of a stock solution; enzymolysis; adsorption; elution; and precipitation. The production method is characterized in that in the step of preparing the stock solution, a raw material is originated from brine for treating a semi-finished product casing; parameter adjustment is carried out in the enzymolysis step to guarantee correspondence with components of the stock solution so as to ensure the enzymolysis effect. The method disclosed by the invention is suitable for producing the brine heparin sodium, wherein the raw material is originated from casing processing brine. The heparin component in the small intestine of a pig can be fully extracted to avoid waste on raw materials, so that the extraction efficiency and the production efficiency of the brine heparin sodium can be improved.

Description

technical field [0001] The invention relates to the production technology of heparin sodium, in particular to a production method of saline heparin sodium. Background technique [0002] Heparin sodium is a mucopolysaccharide sulfate anticoagulant drug, which is the sodium salt of aminodextran sulfate extracted from the intestinal mucosa of pigs or cattle, and belongs to mucopolysaccharides. Studies in recent years have proved that heparin sodium also has the effect of lowering blood lipids, and has very high medicinal value. Saline heparin sodium refers to the heparin sodium prepared from the saline remaining in the sausage casing processing and dehydration step. [0003] The production of the existing heparin sodium generally needs to go through process steps such as stock solution acquisition, enzymatic hydrolysis, adsorption, elution and precipitation. Wherein, the existing process of obtaining the original solution during the preparation of heparin sodium all adopts th...

AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned temperature detection mechanism adopts an expansion thermometer and an elastic rubber plug to cooperate to realize the detection, and has the following defects: 1. The two ends of the thermometer are suspended in the air, which is easy to be broken or damaged. cause damage to the thermometer

2. When the water level in the tank changes, it is necessary to insert or pull out a part of the thermometer to soak the lower end into the liquid surface, which is very inconvenient to operate

3. Since the lower end of the thermometer is not immersed in the liquid surface deeply, only the temperature of the liquid surface can be detected. The temperature of the liquid surface fluctuates greatly, and it is difficult to truly reflect the internal temperature of the tank.

4. The expansion thermometer still has the defect that the temperature display is not clear and needs to be viewed closely

Images