A quantitative detection device for port wine stain blood vessels based on photoacoustic microscopy

Abstract

The invention discloses a photoacoustic microscopy imaging-based quantitative detection device for a nevus flammeus blood vessel. The device comprises two parts, namely hardware and software, wherein the hardware comprises a light emitting system, an optical rapid scanning system, a photoacoustic detection system, an X, Y and Z-axis motor positioning system and a host computer system; the software comprises driving, deconvolution and filter back-projection algorithms of various hardware, and three scanning imaging modes; the imaging depth of the device is 2mm; the transverse resolution is 3.8mu m; the axial resolution is 40mu m; the imaging range is 0.5mm or 1mm; the problem that a pure optical method cannot reach the imaging depth, and ultrasound cannot reach the resolution are solved; two-dimensional and three-dimensional structure imaging is adopted, so that the parameters such as pipe diameter and depth of the blood vessel, and relative blood volume percentage distributed along the depth direction can be quantitatively counted; the defects and disadvantages in an existing clinical PWS detection technology are solved; and a non-destructive real-time multi-mode detection method is provided for PWS pathological study.

Description

technical field [0001] The invention belongs to the research field of photoacoustic microscopic imaging, and in particular relates to a quantitative detection device for port wine stain blood vessels based on photoacoustic microscopic imaging. Background technique [0002] Port Wine Stain (PWS) is classified as a benign microvascular malformation with an incidence of about 3‰-5‰. It is a disease of deep and large dermal vessels in the lesion site, which is prone to occur in the face, arms and neck. With age, the skin color will gradually darken and cause skin thickening and nodules, which will not disappear on their own. Because PWS will expand the area of ​​the lesion area with the increase of age, and it is easy to bleed after trauma, and it may also cause Sturge-Weber syndrome, which not only brings serious psychological pressure to the patient, It may also cause tissue calcification and loss of nerve cells in the cerebral cortex. [0003] At present, the diagnosis and...

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings and deficiencies of the prior art, the object of the present invention is to provide a quantitative detection device for port wine stains blood vessels based on photoacoustic microscopic imaging. The device uses high-speed two-dimensional scanning and high-frequency ultrasonic detection technology, It can achieve a micron-level resolution in the depth range of 2mm, and has three scanning imaging modes, which can solve the shortcomings and blind spots of the current clinical real-time detection of port wine stains

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