Improved preparation method of propranolol

Abstract

The invention discloses an improved preparation method of propranolol, which comprises the following step: in an organic solvent, 3-(1-naphthoxy)-1,2-propylene oxide reacts with isopropylamine under the action of a catalyst so as to obtain the propranolol. Compared with an existing preparation method, the method has the advantages that the preparation method is simple and convenient, reaction conditions are mild, the process is easy to control and the preparation method has small side effects; the catalyst has high catalytic activity and selectivity, is environmental-friendly and can be repeatedly used; a product is easy to separate and purify, the finished product with high purity can be obtained, yield is high, a small quantity of three wastes are generated, and the preparation method has low pollution and is suitable for industrial production.

Description

technical field

[0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to an improved preparation method of propranolol. Background technique

[0002] Propranolol hydrochloride is the first β-receptor blocker used clinically, and has made great contributions to the treatment of hypertension and angina pectoris. Scientist James Blake won the 1988 Nobel Prize in Medicine and the Queen's Award for this.

[0003] Propranolol hydrochloride chemical name: 1-isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride. The activity of the left-handed body is stronger than that of the right-handed body, and its racemic body is used clinically. Its structural formula is as follows:

[0004]

[0005] Propranolol hydrochloride is a commonly used clinical β-adrenoceptor blocker, which can competitively inhibit the effect of catecholamine (catecholamine), and is often used to prevent and treat arrhythmia, angina pectoris, hyper...

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