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Application of Rg1 to preparation of bilirubin rising treating preparation

A technology for bilirubin and preparations, which is applied in the application field of Rg1 in the preparation of preparations for treating elevated bilirubin

Inactive Publication Date: 2015-03-04
YUNNAN JECUI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the effects of anti-aging, improving immunity, and promoting learning and memory, but there is no report about the treatment of metabolic abnormalities and related diseases caused by drinking alcohol with ginsenoside Rg1.

Method used

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  • Application of Rg1 to preparation of bilirubin rising treating preparation
  • Application of Rg1 to preparation of bilirubin rising treating preparation
  • Application of Rg1 to preparation of bilirubin rising treating preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Protective effect of ginsenoside Rg1 on mice with metabolic disorders after single drinking

[0018] 1. Materials and methods

[0019] 1.1 Animals: male healthy C57 mice (20-22g), purchased from the Laboratory Animal Resource Center of China National Institutes for Food and Drug Control, certificate number (SCXK (Beijing) 2009-0017), animals were kept in clean animal rooms, free Eat and drink. Experiments were started after three days of acclimatization.

[0020] 1.2 Drugs and instruments: Ginsenoside Rg1 (purity>95%, provided by Yunnan Jicui Biotechnology Co., Ltd.), ethanol (Red Star Erguotou 56%), Hitachi automatic biochemical analyzer (Japan), triglyceride (TG) detection reagent The box was purchased from Zhongsheng Beikong Biotechnology Co., Ltd.

[0021] 1.3 Preparation of liquid medicine: Ginsenoside Rg1 was dissolved in double distilled water, the concentrations were 4mg / ml, 2mg / ml and 1mg / ml respectively, and the administration volume was 10ml / kg ...

Embodiment 2

[0031] Example 2: Protective effect of ginsenoside Rg1 on metabolic disorders caused by severe drinking and related diseases

[0032] 1.1 Animals: male healthy C57 mice (20-22g), purchased from the Experimental Animal Resource Center of the China Institute for Food and Drug Control, certificate number (SCXK (Beijing) 2009-0017), the animals were kept in a clean animal room, free Eat and drink. Experiments were started after three days of acclimatization.

[0033] 1.2 Drugs and instruments: Ginsenoside Rg1 (purity>95%, provided by Yunnan Jicui Biotechnology Co., Ltd.), ethanol (Red Star Erguotou 56%) Hitachi automatic biochemical analyzer (Japan), alanine aminotransferase kit, aspartate aminotransferase reagent kit, lactate dehydrogenase kit, triglyceride kit, cholesterol kit, low-density lipoprotein kit, high-density lipoprotein kit, bilirubin kit, bile acid kit, creatinine kit were purchased from Zhongsheng Beikong Biotechnology Co., Ltd.

[0034] 2. Animal grouping and tr...

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PUM

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Abstract

The invention relates to application of ginsenoside Rg1 to preparation of a bilirubin rising treating preparation. In a single drinking experiment, the Rg1 can obviously reduce the content of triglyceride in blood; in a heavy drinking model, the Rg1 can obviously improve the survival rate of a drinking mice, reduces the content of glutamic pyruvic transaminase and glutamic oxalacetic transaminase in blood serum, reduces the content of cholesterol, the triglyceride and bilirubin in blood, and the like.

Description

technical field [0001] The invention relates to the application of ginsenoside Rg1 in the preparation of a preparation for treating elevated bilirubin. Background technique [0002] Drinking alcohol can cause metabolic disorders in the body and lead to a series of diseases. The main manifestations are that drinking alcohol can increase the incidence of diabetes, hyperlipidemia, and hypertension, thereby promoting the occurrence of metabolic syndrome. Metabolic syndrome takes lipid metabolism disorder as its core content, mainly including hypertriglyceridemia (TG) and low high-density lipoprotein-cholesterolemia. Alcohol consumption can stimulate the release of fatty acids from adipose tissue and slow down the clearance of very low-density lipoprotein (VLDL) and chylomicrons from the blood. Triglycerides, elevated cholesterol levels and other disorders. [0003] In addition to affecting lipid metabolism, drinking alcohol can cause damage to various organs. For example, acet...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/16A61P3/06
CPCA61K31/704
Inventor 楚世峰刘克超
Owner YUNNAN JECUI BIOTECH
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