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Medical povidone-iodine dressing and preparation method thereof

A technology of povidone-iodine and chitosan, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of weakened bactericidal ability and short duration of drug effect, and achieve the purpose of delaying the release of drug effect and wide application value. Effect

Active Publication Date: 2015-04-01
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wound dressings made of povidone-iodine can be used to treat burns, skin ulcers, gynecological diseases, etc., but because povidone-iodine is highly water-soluble, existing povidone-iodine dressings have a duration of drug effect Not long, the problem that the bactericidal ability gradually weakens with the increase of time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A medical povidone-iodine dressing, comprising the following components in parts by weight: 10 parts of styrene-isoprene block copolymer, 20 parts of povidone-iodine, 5 parts of ethyl cellulose, chitosan 5 parts, 4 parts of rosin, 1 part of tributyl citrate, 10 parts of zinc dibutyldithiocarbamate and 50 parts of water.

[0021] The preparation method is as follows:

[0022] (1) each component is taken by weight;

[0023] (2) Melt the styrene-isoprene block copolymer and ethyl cellulose in the reactor, the temperature is controlled at 140°C, after the copolymer is completely melted, add chitosan and rosin to the reactor , tributyl citrate and zinc dibutyldithiocarbamate, heat preservation;

[0024] (3) dissolving povidone iodine in water, stirring to make povidone iodine aqueous solution, slowly adding the mixture obtained in step (2) into povidone iodine aqueous solution, stirring evenly, vacuumizing and degassing;

[0025] (4) The product obtained in step (3) is po...

Embodiment 2

[0027] A medical povidone-iodine dressing, comprising the following components in parts by weight: 10 parts of styrene-isoprene block copolymer, 15 parts of povidone-iodine, 10 parts of ethyl cellulose, chitosan 5 parts, 8 parts of rosin, 2 parts of acetyl tributyl citrate, 10 parts of 2,6-di-tert-butyl-4-methylphenol and 60 parts of water.

[0028] The preparation method is as follows:

[0029] (1) each component is taken by weight;

[0030] (2) Melt the styrene-isoprene block copolymer and ethyl cellulose in the reactor, the temperature is controlled at 140°C, after the copolymer is completely melted, add chitosan and rosin to the reactor , Acetyl tributyl citrate and 2,6-di-tert-butyl-4-methylphenol, keep warm;

[0031] (3) dissolving povidone iodine in water, stirring to make povidone iodine aqueous solution, slowly adding the mixture obtained in step (2) into povidone iodine aqueous solution, stirring evenly, vacuumizing and degassing;

[0032] (4) The product obtained...

Embodiment 3

[0034] A medical povidone-iodine dressing, comprising the following components in parts by weight: 20 parts of styrene-isoprene block copolymer, 15 parts of povidone-iodine, 10 parts of ethyl cellulose, chitosan 10 parts, 4 parts of C5 resin, 3 parts of tributyl citrate, 5 parts of zinc dibutyldithiocarbamate and 70 parts of water.

[0035] The preparation method is as follows:

[0036] (1) each component is taken by weight;

[0037] (2) Melt the styrene-isoprene block copolymer and ethyl cellulose in the reactor, the temperature is controlled at 150°C, after the copolymer is completely melted, add chitosan, C5 Resin, tributyl citrate and zinc dibutyldithiocarbamate, heat preservation;

[0038] (3) dissolving povidone iodine in water, stirring to make povidone iodine aqueous solution, slowly adding the mixture obtained in step (2) into povidone iodine aqueous solution, stirring evenly, vacuumizing and degassing;

[0039] (4) The product obtained in step (3) is poured into a...

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PUM

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Abstract

The invention provides a medical povidone-iodine dressing and a preparation method thereof. The dressing comprises the following components: a styrene-isoprene segmented copolymer, povidone-iodine, ethylcellulose, chitosan, a tackifier, a plasticizer, an anti-aging agent and water. The preparation method comprises the following steps: weighing the components; melting the styrene-isoprene segmented copolymer and ethylcellulose in a reaction kettle, and adding chitosan, the tackifier, the plasticizer and the anti-aging agent after the styrene-isoprene segmented copolymer and ethylcellulose are fully melted, and insulating; dissolving povidone-iodine in water, slowly adding the mixture into the povidone-iodine aqueous solution, uniformly stirring and vacuumizing and defoaming; and pouring the obtained product in a mould, freezing and standing at room temperature to obtain the dressing. The medical povidone-iodine dressing provided by the invention not only can be used for maintaining a moist environment required by wound healing, but also can be used for alleviating the efficacy release of povidone-iodine, sterilizes for a long time and has a broad application value.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a medical povidone-iodine dressing and a preparation method thereof. Background technique [0002] The correct treatment of surgical wounds is one of the keys to the success of surgical treatment, and good wound healing is the prerequisite for the recovery of body functions after trauma. Therefore, research on accelerating wound healing is very important, and the development of wound dressings is one of the hotspots of research. one. Research on wound healing shows that the purpose of using dressings is not only to cover the wound surface, but also to promote wound healing. [0003] Povidone-iodine is a complex formed of iodine and polyvinylpyrrolidone. Due to the presence of iodine, it has a strong bactericidal ability. It is a broad-spectrum, high-efficiency, low-toxicity, and safe disinfectant. Wound dressings made of povidone-iodine can be used to treat burns, skin ulcers, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/44
Inventor 李苏杨徐勤霞
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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