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Hyperthermic devitalization extraction method of rhodiola rosea injection

An extraction method, Rhodiola rosea technology, which is applied in the directions of medical formula, drug delivery, drug combination, etc., can solve the problems of lower salidroside content and lower production yield, and achieve the effect of ensuring curative effect and improving product yield

Active Publication Date: 2015-04-22
TONGHUA YUSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The extraction process of Rhodiola rosea is water extraction and alcohol precipitation. The contact temperature between the medicinal material and cold water gradually rises in the initial stage of extraction. During this process, the degrading enzymes in the medicinal material can Decompose salidroside, resulting in a decrease in salidroside content, thus reducing the yield of the product

Method used

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  • Hyperthermic devitalization extraction method of rhodiola rosea injection

Examples

Experimental program
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Effect test

Embodiment 1

[0012] High temperature inactivation extraction method of Rhodiola injection

[0013] Add 9kg of water to the extraction tank, heat the water to 80°C or higher, add 1.5kg of Rhodiola rosea medicinal material, continue heating at a temperature of 98-100°C, extract for 2 hours, extract three times, combine the extracts, and concentrate the filtrate to relative For clear paste with a density of 1.15-1.20 (50°C), add ethanol to make the alcohol content reach 65%, stir well, refrigerate for 24 hours (5-10°C), filter, recover ethanol and concentrate to a relative density of 1.15-1.20 (50°C), add ethanol to make the alcohol content reach 85%, stir well, refrigerate for 24 hours (5-10°C), filter, recover ethanol from the filtrate and concentrate to a relative density of 1.20-1.30 (50°C ), add 1000ml of water for injection, adjust the pH value to 7.0, heat and boil for 30 minutes, refrigerate for 72 hours (5-10°C), filter, and the filtrate is ultrafiltered with an ultrafiltration colum...

Embodiment 2

[0015] High temperature inactivation extraction method of Rhodiola injection

[0016] Add 9kg of water to the extraction tank, heat the water to 80°C, put in 1.5kg of Rhodiola rosea medicinal material, continue heating at a temperature of 98-100°C, extract for 2 hours, extract three times, combine the extracts, and concentrate the filtrate to a relative density of 1.15-1.20 (50°C) clear ointment, add ethanol to make the alcohol content reach 65%, stir well, refrigerate for 24 hours (5-10°C), filter, recover ethanol and concentrate to a relative density of 1.15-1.20 (50 ℃), add ethanol to make the alcohol content reach 85%, stir well, refrigerate for 24 hours (5-10 ℃), filter, recover ethanol from the filtrate and concentrate to a relative density of 1.20-1.30 (50 ℃) Clear the ointment, add 1000ml of water for injection, adjust the pH value to 7.0, heat and boil for 30 minutes, refrigerate for 72 hours (5-10°C), filter, and the filtrate is ultrafiltered with an ultrafiltration ...

Embodiment 3

[0018] High temperature inactivation extraction method of Rhodiola injection

[0019] Add 9kg of water to the extraction tank, heat the water to 80°C or higher, add 1.5kg of Rhodiola rosea, continue to heat, boil, extract for 2 hours, extract three times, combine the extracts, and concentrate the filtrate to a relative density of 1.15-1.20 (50°C), add ethanol to make the alcohol content reach 65%, stir well, refrigerate for 24 hours (5-10°C), filter, recover ethanol and concentrate to a relative density of 1.15-1.20 (50°C) Clear the paste, add ethanol to make the alcohol content reach 85%, stir well, refrigerate for 24 hours (5-10°C), filter, recover the ethanol from the filtrate and concentrate it to a clear paste with a relative density of 1.20-1.30 (50°C), Add 1000ml of water for injection, adjust the pH value to 7.0, heat and boil for 30 minutes, refrigerate for 72 hours (5-10°C), filter, and the filtrate is ultrafiltered with an ultrafiltration column with a molecular wei...

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Abstract

The invention relates to a method for preparing traditional Chinese medicine preparations, and particularly relates to a hyperthermic devitalization extraction method of a rhodiola rosea injection. Sofren injection has the effect of promoting blood circulation to remove stasis. According to the method, degrading enzyme in the rhodiola rosea medicinal material is inactivated in a short time in 80-90 DEG C high-temperature water by adopting an extracting technology of feeding materials in 80-90 DEG C high-temperature water, and salidroside is prevented from being decomposed by degrading enzyme in an aqueous solution in a process of heating cold water, and the product yield is improved.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a high-temperature inactivation extraction method of Rhodiola injection in 80°C high-temperature water to deactivate degrading enzymes in medicinal materials. Background technique [0002] In the existing technology, Dazhu Rhodiola Injection is a patented product (ZL99102847.3) exclusively produced by Tonghua Yusheng Pharmaceutical Co., Ltd. Properties: This product is light yellow to brownish-yellow clear liquid. Ingredients: Rhodiola rosea. Adaptive symptoms: promoting blood circulation and removing blood stasis. Stable exertional angina with coronary heart disease. Symptoms: Chest stabbing pain, colic, immobility, pain in the shoulder, back and inner arm, chest tightness, palpitations, dark purple lips and tongue, thready and astringent pulse. Usage and dosage: intravenous drip. Add 10ml at a time to 250ml of 5% glucose injection, once ...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61K9/08A61P9/10
Inventor 赵国华曹明光房宗宝崔立萍
Owner TONGHUA YUSHENG PHARMA
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