Novel application of gentiana straminea maxim alcohol extract to anti-anoxia

A technology of germinol and anti-hypoxia, applied in the field of application of the alcohol extract of gentianol in the preparation of anti-hypoxic drugs

Inactive Publication Date: 2015-04-29
TIBET UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention relates to the anti-hypoxic new application of Gentiana alcohol extract and its application in anti-hypoxic drugs. There is no report at home and abroad, and it belongs to the first

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  • Novel application of gentiana straminea maxim alcohol extract to anti-anoxia

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Experimental program
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Embodiment Construction

[0014] 1. Experimental materials

[0015] Experimental animals: Kunming mice, weighing 20±2g, half male and half male (provided by Animal Experiment Center of Xi'an Jiaotong University)

[0016] Experimental drug Gentiana chinensis, produced in Tibet, was purchased from the Tibetan Medicine Factory of Tibetan Medical College

[0017] Propranolol Hydrochloride Linfen Jianmin Pharmaceutical Factory, Shanxi Province

[0018] Sodium nitrite Xi'an Chemical Reagent Factory (GB1266-77)

[0019] Isoproterenol Hydrochloride Injection Shanghai Hefeng Pharmaceutical Co., Ltd.

[0020] Experimental Instrument 722s Visible Spectrophotometer Shanghai Precision Scientific Instrument Co., Ltd.

[0021] ZDQ-2121A Micro Vortex Mixer Jintan Shenglan Instrument Manufacturing Co., Ltd.

[0022] T-214 Electronic Balance Beijing Jiduolisi Instrument System Co., Ltd.

[0023] Pipette gun Dalong Medical Equipment (Shanghai) Co., Ltd.

[0024]...

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Abstract

The invention discloses a novel application of a gentiana straminea maxim alcohol extract to anti-anoxia. Through observing the survival time of mice in various anoxia models such as normal-pressure anoxia, sodium nitrite toxic chemical anoxia, myocardial anoxia and acute cerebral ischemic anoxia, the hydrogen peroxide (CAT) content, the superoxide dismutase (SOD) content, the malondialdehyde (MDA) content and the total antioxidant capacity (T-AOC) of the liver of the normal-pressure anoxic mice are measured to research the anti-anoxia function of the gentiana straminea maxim alcohol extract. The result shows that the gentiana straminea maxim alcohol extract has the functions of remarkably prolonging the survival time of the mice under various anoxia conditions and improving the liver antioxidant enzyme activity of the normal-pressure anoxic mice so as to protect the anoxia-induced liver oxidative stress injury, and the result explains that the gentiana straminea maxim alcohol extract has an anti-anoxia function. The gentiana straminea maxim alcohol extract has a novel application to the preparation of anti-anoxia drugs and has a favorable clinic application prospect.

Description

technical field [0001] The invention relates to a new application of commonly used Tibetan medicine Gentiana genti, in particular to the application of the alcohol extract of Gentiana gentis in preparing anti-hypoxic drugs. Background technique [0002] Oxygen is an important condition for the survival of human beings and many organisms. When the oxygen required to maintain the body's life activities cannot be adequately supplied or oxygen use is impaired, it will lead to abnormal changes in the body's metabolism, function, and even morphological structure. Clinically, many diseases such as heart disease, severe asthma, carbon monoxide poisoning, suffocation, anesthesia and poisoning will cause hypoxia or insufficient oxygen supply in the body; It can cause insufficient relative oxygen supply; special environments such as plateau, diving and aviation are more prone to hypoxia. Severe or long-term hypoxia will bring serious harm to the body, and eventually lead to the death ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61P39/00
Inventor 赵勤王鑫王乐乐陈丽萍魏立鹏宗硕硕袁东亚贺学孙芳云李捷
Owner TIBET UNIVERSITY FOR NATIONALITIES
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