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Pharmaceutical composition for treating chronic nephritis damp heat syndrome and preparation method for pharmaceutical composition

A composition and drug technology, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of long treatment course of Western medicine, many side effects, easy to rebound, etc., to achieve less toxic side effects and less drug smell , the effect of medicinal power

Inactive Publication Date: 2015-04-29
尹庆锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of treatment, Western medicine has formed a relatively complete treatment system. The clinical efficacy of hormones, immunosuppressants, RAS blockers, and anticoagulants have been verified in the industry for a long time. It is believed that they can effectively control proteinuria, Protect renal function, but these treatments are mainly aimed at patients with clinical manifestations of nephrotic syndrome or nephrotic range proteinuria, and are not completely suitable for non-nephrotic range proteinuria, and the course of western medicine treatment is long, easy to rebound after drug withdrawal, side effects also more

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The beneficial effect of the pharmaceutical composition of the present invention will be further illustrated through test examples below, and these test examples include pharmacodynamic tests and clinical curative effect observation tests.

[0022] The raw materials used in the pharmaceutical composition of the present invention are Astragalus, Eucommia, Radix Polygoni Multiflori, Fructus Rosa, Shiwei, Hedyotis, Cat's Claw, Silkworm, and Angelica sinensis. All are commercially available and meet the relevant standards of the 2010 Pharmacopoeia.

[0023] The oral preparation auxiliary materials used in the pharmaceutical composition of the present invention are all commercially available and meet the standards under the relevant items of the Pharmacopoeia.

[0024] Preclinical pharmacodynamics research results of the pharmaceutical composition of the present invention: the rat bacterial nephritis model is selected, and 23.8g / Kg has a certain therapeutic effect on experim...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating chronic nephritis damp heat syndrome. The pharmaceutical composition is prepared from astragalus membranaceus, eucommia ulmoides, prepared fleece flower roots, cherokee rose fruits, pyrrosia lingua, hedyotis diffusa, radix ranunculi ternati, prepared stiff silkworms and fried angelica sinensis and is suitable for the chronic nephritis damp heat syndrome and primary mesangial proliferative glomerulonephritis. The symptoms are as follows: lumbar acerbity sluggish, short breath, laziness to speak, lusterless complexion, feverishness in palms and soles, dizziness and tinnitus, enuresis nocturna, yellowish fur, bitter taste in mouth, sticky and greasy fur, dry mouth, less drinking, scanty dark urine, difficulty and pain in micturition, recurrent upper respiratory or gastrointestinal tract infection and face and limb edema. The pharmaceutical composition has the effects of benefiting qi, tonifying spleen, clearing heat and promoting diuresis, is not obvious in drug flavor, good in medicinal effect, safe and effective, and can be prepared into various oral preparations.

Description

technical field [0001] The invention relates to a medicinal composition derived from traditional Chinese medicine for treating damp-heat syndrome of chronic nephritis and a preparation method thereof. Background technique [0002] Following the concept of tertiary prevention of chronic kidney disease (CKD) proposed by the international nephrology community, the K / DOQI organization in the United States re-established the clinical practice guidelines for CKD in 1999, pointing out that proteinuria is an important risk factor that accelerates the progression of CKD. one. [0003] Chronic primary glomerular disease is the most common cause of CKD, clinically including chronic glomerulonephritis, occult glomerulonephritis or nephrotic syndrome, pathological manifestations include mild glomerular lesions, focal glomerular Nephritis, focal segmental glomerulosclerosis, mesangial proliferative glomerulonephritis, membranous nephropathy, mesangial capillary nephritis, IgA nephropathy...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61K36/80A61K36/738A61P13/12A61K35/64
CPCA61K36/481A61K9/1652A61K36/11A61K36/19A61K36/232A61K36/28A61K36/34A61K36/46A61K36/704A61K36/71A61K36/738A61K36/748A61K36/80A61K2236/331A61K2236/39
Inventor 尹庆锋
Owner 尹庆锋
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