Method for detecting accumulation-dispersing and bowel-relaxing pharmaceutical preparation

A detection method and technology for pharmaceutical preparations, which can be applied to measurement devices, instruments, scientific instruments, etc., can solve the problems of long analysis time, interference of chromatographic peaks, and the failure of Xiaojitongbian capsule detection to meet the requirements.

Active Publication Date: 2015-05-06
GUIZHOU MAQIKA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above documents have reported the content determination method of Chuanshegan, but according to the above method, the resolution is not good, or the analys

Method used

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  • Method for detecting accumulation-dispersing and bowel-relaxing pharmaceutical preparation
  • Method for detecting accumulation-dispersing and bowel-relaxing pharmaceutical preparation
  • Method for detecting accumulation-dispersing and bowel-relaxing pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] A detection method for a drug preparation for eliminating stagnation and laxative, the steps are as follows:

[0100] Properties: This product is a capsule, the content is light yellow to brown powder; slightly gas, sweet and bitter;

[0101] Identification: (1) Take this product and observe under a microscope: there are many columnar crystals, most of which have been broken, with a diameter of 16-52 μm, and the length of the intact ones is 15-82 μm;

[0102] (2) Take 1g of the content of this product, add methanol 10ml, sonicate for 30 minutes, filter, and the filtrate is concentrated to 1ml, as the test solution; take another 1g of Chuanshegan reference medicinal material, and prepare the reference medicinal material solution in the same way; according to China Pharmacopoeia 2010 edition one appendix VIB thin-layer chromatography test, draw 1 μl of each of the above two solutions, respectively spot on the same polyamide film, use chloroform-butanone-formic acid=3:1:1 ...

Embodiment 2

[0111] A detection method for a drug preparation for eliminating stagnation and laxative, the steps are as follows:

[0112] Properties: This product is a capsule, the content is light yellow to brown powder; slightly gas, sweet and bitter;

[0113] Identification: (1) Take this product and observe under a microscope: there are many columnar crystals, most of which have been broken, with a diameter of 16-52 μm, and the length of the intact ones is 15-82 μm;

[0114] (2) Take 1g of the content of this product, add methanol 10ml, sonicate for 20 minutes, filter, and the filtrate is concentrated to 1ml, as the test solution; take another 1g of Chuanshegan reference medicinal material, and prepare the reference medicinal material solution in the same way; according to China Pharmacopoeia 2010 Edition, Appendix VIB TLC test, draw 1 μl of each of the above two solutions, spot on the same polyamide film respectively, use chloroform-butanone-formic acid=1:0.5:0.5 as developing agent, ...

Embodiment 3

[0123] A detection method for a drug preparation for eliminating stagnation and laxative, the steps are as follows:

[0124] Properties: This product is a capsule, the content is light yellow to brown powder; slightly gas, sweet and bitter;

[0125] Identification: (1) Take this product and observe under a microscope: there are many columnar crystals, most of which have been broken, with a diameter of 16-52 μm, and the length of the intact ones is 15-82 μm;

[0126] (2) Take 1g of the content of this product, add methanol 10ml, sonicate for 40 minutes, filter, and the filtrate is concentrated to 1ml, as the test solution; another 1g of Chuanshegan reference medicinal material is taken, and the reference medicinal material solution is prepared in the same way; according to China Pharmacopoeia 2010 edition one appendix VIB thin-layer chromatography test, draw 1 μ l of each of the above two solutions, respectively spot on the same polyamide film, use chloroform-butanone-formic ac...

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Abstract

The invention discloses a method for detecting an accumulation-dispersing and bowel-relaxing pharmaceutical preparation. The detection method comprises the following steps: discriminating properties, and detecting and measuring extracts and contents, wherein in the discriminating process, iris tectorum maxim is subjected to qualitative discrimination, specifically, iris tectorum maxim is regarded as a reference crude herb and trichloromethane-butanone-methanoic acid with the ratio of (1-5):(0.5-2):(0.5-2) is regarded as a developing solvent, and iris tectorum maxim is discriminated by a thin layer chromatography; the content measurement of iris tectorum maxim is that tectoridin in iris tectorum maxim is measured according to the high efficiency liquid chromatography of appendix VD of Chinese pharmacopoeia 2010. In comparison with an existing technology, the method for detecting the accumulation-dispersing and bowel-relaxing pharmaceutical preparation is established, and the method is scientific and reasonable, high in accuracy, and excellent in reproducibility, thus the quality of a accumulation-dispersing and bowel-relaxing capsule can be comprehensively and effectively controlled and the clinical efficacy and security of the preparation can be better ensured.

Description

technical field [0001] The invention relates to a detection method of medicines, in particular to a detection method of a drug preparation for eliminating stagnation and laxatives, and belongs to the technical field of medicines. Background technique [0002] Constipation is a common clinical symptom, which can cause many discomforts to patients, such as difficulty in defecation, dry stool, defecating only once in a few days or even a week, and there may be cramping pain in the left abdomen and a feeling of falling when defecating, and some patients complain of bitter mouth and loss of appetite , abdominal distension, lower abdominal discomfort, excess exhaust or dizziness, headache, fatigue and other neurosis. Xiaoji Laxative Capsules are made by crushing Chuan Shegan into fine powder and packing them into capsules. Chuanshegan is the dry rhizome of Iris tectorum Maxim., a plant of the family Irisaceae. It has a slight gas, sweet and bitter taste. "Dictionary of Tradition...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 张芝庭吕如忠何丹杨勇张涛涛
Owner GUIZHOU MAQIKA PHARMA
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