Long-acting cefotaxime sodium injection and preparation method thereof

A technology of cefotaxime sodium and injection, which is applied in the field of long-acting cefotaxime sodium injection, can solve problems such as no reports, and achieve the effects of prolonging drug effect, reducing occurrence probability, and reducing the number of drugs

Active Publication Date: 2015-05-27
BEIJING RED SUN PHARMA
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on injectable hydrogel preparations mainly focuses on proteins

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Long-acting cefotaxime sodium injection and preparation method thereof
  • Long-acting cefotaxime sodium injection and preparation method thereof
  • Long-acting cefotaxime sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepare 30 mg / mL N-succinyl chitosan solution, carboxymethyl chitosan solution, and oxidized chondroitin sulfate solution respectively, and add 1 g of cefotaxime sodium to 50 mL of In the N-succinyl chitosan solution, keep stirring, slowly add 40mL carboxymethyl chitosan solution after 30min, keep stirring, add 60mL oxidized chondroitin sulfate solution and 20mL glutaraldehyde with a concentration of 50% at a uniform speed after 25min The solution was added within 2 minutes at a constant speed, mixed for 1 hour at a stirring speed of 5000 RPM, injected into a circular mold with a bottom diameter of 10 mm to form a drug-loaded hydrogel, and vacuum-dried at room temperature to a constant weight to obtain a dry load. Potion gel.

Embodiment 2

[0037] Prepare 30 mg / mL N-succinyl chitosan solution, carboxymethyl chitosan solution, and oxidized chondroitin sulfate solution respectively, and add 1 g of cefotaxime sodium to 70 mL of In the N-succinyl chitosan solution, keep stirring, slowly add 20mL carboxymethyl chitosan solution after 30min, keep stirring, add 60mL oxidized chondroitin sulfate solution and 20mL glutaraldehyde with a concentration of 50% at a uniform speed after 25min The solution was added within 2 minutes at a constant speed, mixed for 1 hour at a stirring speed of 5000 RPM, injected into a circular mold with a bottom diameter of 10 mm to form a drug-loaded hydrogel, and vacuum-dried at room temperature to a constant weight to obtain a dry load. Potion gel.

Embodiment 3

[0039] Prepare 30 mg / mL N-succinyl chitosan solution, carboxymethyl chitosan solution, and oxidized chondroitin sulfate solution respectively, and add 1 g of cefotaxime sodium to 30 mL of In the N-succinyl chitosan solution, keep stirring, slowly add 60mL carboxymethyl chitosan solution after 30min, keep stirring, add 60mL oxidized chondroitin sulfate solution and 20mL glutaraldehyde with a concentration of 50% at a uniform speed after 25min The solution was added within 2 minutes at a constant speed, mixed for 1 hour at a stirring speed of 5000 RPM, injected into a circular mold with a bottom diameter of 10 mm to form a drug-loaded hydrogel, and vacuum-dried at room temperature to a constant weight to obtain a dry load. Potion gel.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a long-acting cefotaxime sodium injection and a preparation method of the injection. The injection comprises a biodegradable polymer material, wherein the biodegradable polymer material comprises an injectable hydrogel. The preparation method comprises the following steps: mixing the medicines and N-chitosan succinate solution at a certain temperature and stirring rate, and mixing the mixture with carboxymethyl chitosan solution; adding oxidized chondroitin sulfate solution and glutaraldehyde solution in a certain time while stirring, injecting the solution into a circular mold with the bottom diameter of 10mm after stirring, forming drug-loading hydrogel, and performing vacuum drying to constant weight at room temperature.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a long-acting cefotaxime sodium injection and a preparation method of the injection. Background technique [0002] Cefotaxime is a third-generation cephalosporin with a broad antibacterial spectrum and strong activity against Gram-negative bacteria such as Escherichia coli, Proteus mirabilis, Klebsiella, and Salmonella. It also has a good effect on Proteus vulgaris and Citrobacter, and is suitable for pneumonia and other lower respiratory tract infections, urinary tract infections, meningitis, sepsis, abdominal infections, pelvic infections, skin and soft tissue infections, and reproductive tract infections caused by sensitive bacteria. Infection, bone and joint infection, etc., can be used as the drug of choice for children with meningitis. [0003] The chemical name of cefotaxime sodium is: (6R,7R)-3-[(acetoxy)methyl]-7-[2-amino-4-thiazolyl-(methoxyimino)acetamid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/06A61K31/546A61K47/36A61P31/04C08B37/08
Inventor 林德良
Owner BEIJING RED SUN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap