Long-acting cefotaxime sodium injection and preparation method thereof

A technology of cefotaxime sodium and injection, which is applied in the field of long-acting cefotaxime sodium injection, can solve problems such as no reports, and achieve the effects of prolonging drug effect, reducing occurrence probability, and reducing the number of drugs
CN104644547AActive Publication Date: 2015-05-27BEIJING RED SUN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING RED SUN PHARMA
Publication Date
2015-05-27

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Abstract

The invention relates to a long-acting cefotaxime sodium injection and a preparation method of the injection. The injection comprises a biodegradable polymer material, wherein the biodegradable polymer material comprises an injectable hydrogel. The preparation method comprises the following steps: mixing the medicines and N-chitosan succinate solution at a certain temperature and stirring rate, and mixing the mixture with carboxymethyl chitosan solution; adding oxidized chondroitin sulfate solution and glutaraldehyde solution in a certain time while stirring, injecting the solution into a circular mold with the bottom diameter of 10mm after stirring, forming drug-loading hydrogel, and performing vacuum drying to constant weight at room temperature.
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Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a long-acting cefotaxime sodium injection and a preparation method of the injection. Background technique

[0002] Cefotaxime is a third-generation cephalosporin with a broad antibacterial spectrum and strong activity against Gram-negative bacteria such as Escherichia coli, Proteus mirabilis, Klebsiella, and Salmonella. It also has a good effect on Proteus vulgaris and Citrobacter, and is suitable for pneumonia and other lower respiratory tract infections, urinary tract infections, meningitis, sepsis, abdominal infections, pelvic infections, skin and soft tissue infections, and reproductive tract infections caused by sensitive bacteria. Infection, bone and joint infection, etc., can be used as the drug of choice for children with meningitis.

[0003] The chemical name of cefotaxime sodium is: (6R,7R)-3-[(acetoxy)methyl]-7-[2-amino-4-thiazolyl-(methoxyimino)acetamid...

Claims

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