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First-aid plasma substitute medicine composition and preparation method thereof

A composition and drug technology, which can be used in drug combinations, blood diseases, active ingredients of alkaline/alkaline earth metal chlorides, etc., can solve problems such as renal dysfunction, nervous system disorders, blood cell rupture, cardiac insufficiency, etc., and achieve drug accumulation. Low tendency, reduced edema, improved blood loss symptoms

Inactive Publication Date: 2015-05-27
PEKING UNIV FOUNDER GRP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hypertonic solutions such as 7.5% (w / v) sodium chloride and 7.2% sodium chloride, but this hypertonic concentration of sodium chloride has certain toxicity to the body and often leads to complications, such as hypotension, hypertonicity Blood cell rupture, cardiac insufficiency, renal insufficiency, and nervous system disorders
[0005] At present, the existing plasma substitutes can not meet the needs of clinical application well, and a better plasma substitute pharmaceutical composition is needed to be used in the field of first aid for the wounded and sick, especially for the rescue of hemorrhagic shock caused by acute trauma

Method used

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  • First-aid plasma substitute medicine composition and preparation method thereof
  • First-aid plasma substitute medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Hydroxyethyl starch 200 / 0.5 raw material preparation: take amylopectin as the starting material, hydrolyze, hydroxyethylate, and refine.

Embodiment 2

[0025] Hydroxyethyl starch 200 / 0.5 6g

[0026] Sodium chloride 4.2 grams

[0027] Add water for injection to 100ml

[0028] Dissolve hydroxyethyl starch in water for injection, stir and heat at 90°C for 15 minutes, add sodium chloride and stir to dissolve, stir and heat at 90°C for 10 minutes, filter, fill, and sterilize to obtain the product.

Embodiment 3

[0030] Hydroxyethyl starch 200 / 0.5 10g

[0031] Sodium chloride 2 grams

[0032] Add water for injection to 100ml

[0033] Dissolve hydroxyethyl starch in water for injection, stir and heat at 90°C for 15 minutes, add sodium chloride and stir to dissolve, stir and heat at 90°C for 10 minutes, filter, fill, and sterilize to obtain the product.

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PUM

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Abstract

The invention discloses a first-aid plasma substitute medicine composition and a preparation method thereof. The medicine composition includes 2-6% (w / v) of sodium chloride and 4-10% (w / v) of hydroxyethyl starch, wherein the average molecular weight of the hydroxyethyl starch is 200000 + / - 20000 Dolton. The medicine composition is strong in plasma volume expansion effect, is durable in effect, is low in tendency of medicine accumulation, is high in safety and is less in influence on blood clotting in human body. The medicine composition can be used for treating hemorrhagic shock due to various factors, can be used in first aid of patient suffered from trauma and burn as a plasma substitute, and is employed as the plasma substitute in various surgery.

Description

technical field [0001] The invention relates to a blood plasma replacement pharmaceutical composition for emergency use and a preparation method thereof, belonging to the technical field of pharmaceutical compositions. Background technique [0002] The traditional resuscitation of hemorrhagic shock is to use isotonic crystalloid and / or colloid fluid to infuse early, quickly, and in sufficient quantities, with the goal of restoring hemodynamics as soon as possible. ), and even developed into multiple organ dysfunction syndrome (MODS). Acute respiratory distress syndrome (ARDS) and MODS are currently the main causes of delayed death after resuscitation of trauma-hemorrhagic shock. Resuscitation methods that can reduce the inflammatory response and organ damage after resuscitation are the current focus of attention in the treatment of hemorrhagic shock. [0003] Compared with isotonic solutions, hypertonic solutions have the advantages of inhibiting the activation of neutroph...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P7/08A61K31/718
Inventor 易崇勤邹明琛郭欲晓谢小飞李育巧
Owner PEKING UNIV FOUNDER GRP CO LTD
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