Synthesis method of etoricoxib

A technology of etoricoxib and a synthesis method, applied in the field of synthesizing etoricoxib, can solve the problems of easy deterioration of sodium methoxide, large loss, flammability and explosion, etc., and achieves simplified post-processing process, improved synthesis steps, simplified reaction operation Effect
CN104693113AInactive Publication Date: 2015-06-10JIANGSU TIANHE PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU TIANHE PHARMA CO LTD
Publication Date
2015-06-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a synthesis method of etoricoxib and relates to the technical field of synthesis of non-steroid anti-inflammatory drugs. According to the synthesis method, the synthesis steps of the non-steroid anti-inflammatory drug etoricoxib are improved by use of a phase-transfer catalytic reaction, and therefore, the cost is greatly reduced, the yield is improved and the safety is also improved.
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Description

technical field

[0001] The invention relates to the technical field of synthesis of non-steroidal anti-inflammatory drugs, especially etoricoxib. Background technique

[0002] Etoricoxib (5-chloro-6-methyl-3[4-(methylsulfonyl)phenyl]-2,3-bipyridine), molecular formula: C 18 h 15 ClN 2 o 2 S. Etoricoxib is an important non-steroidal anti-inflammatory drug, a highly selective cyclooxygenase-2 inhibitor, and an important analgesic drug. Its performance is better than that of traditional non-steroidal anti-inflammatory drugs. It has been greatly improved, and it is the only proven coxib drug for the treatment of acute gout and arthritis, and it has become the first choice drug for the treatment of rheumatoid arthritis in my country, so the market potential is huge.

[0003] The research on the synthesis of etoricoxib at home and abroad has never stopped. At present, there are many reports on the synthesis of etoricoxib, and one of the methods is currently the method with...

Claims

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