Dementia prevention and treatment rhizoma gastrodiae extract or composition

A technology for the prevention and treatment of dementia, extracts, applied in the direction of drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of lack of pharmacodynamic data, etc., to achieve good synergistic compatibility and clear medicinal substances Effect

Inactive Publication Date: 2015-06-17
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

N6-Hydroxybenzyladenosine is an active compound found in Gastrodia elata, which has been reported to have good neuroprotective effects (J.Nat.Prod., 2007, 70, 571-574) and sedative-hypnotic activity (Chinese patent 200810114594.3; PCT patent 200980162826.5), but these derivatives are chemically synthesized, and there is a lack of pharmacodynamic data directly related to dementia

Method used

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  • Dementia prevention and treatment rhizoma gastrodiae extract or composition
  • Dementia prevention and treatment rhizoma gastrodiae extract or composition
  • Dementia prevention and treatment rhizoma gastrodiae extract or composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Effect of Gastrodia elata extract on learning and memory in rats with cerebral ischemia-reperfusion injury in the forebrain

[0030] Animal model: rat forebrain cerebral ischemia-reperfusion injury model

[0031] Modeling method: rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (according to 0.35ml / 100g body weight), depilated and disinfected the anterior neck area. A median neck incision about 3 cm in length was made, and the bilateral common carotid arteries (CCA) were exposed and separated layer by layer. Be careful not to damage the vagus nerve. A 5cm-long silk thread was placed under each of the bilateral common carotid arteries, and both ends of the thread were clamped with vascular forceps to clamp both arteries at the same time. After 40 minutes, the silk thread was loosened at the same time to reperfuse the blood, and a little penicillin powder was applied locally to the operation area. , Suture the incision layer by layer.

[00...

Embodiment 2

[0040] Example 2: Effect of Gastrodia elata extract on learning and memory in rats with forebrain ischemia-reperfusion injury

[0041] Animal model: rat forebrain cerebral ischemia-reperfusion injury model

[0042] The modeling method, animal grouping, administration method and water maze detection index are the same as in Example 1, wherein P4-P6 represent the parisin components; N3-N4 represent nucleosides. The results of the water maze experiment are shown in Table 2.

[0043] After the water maze test, the brain was decapitated, the cortical brain tissue was separated on ice, and the following indicators were tested after homogenization:

[0044] In the brain tissue, the content of lipid peroxidation product MDA (Nanjing Jiancheng) and SOD related to free radical scavenging, acetylcholinesterase and acetylcholine transferase related to acetylcholine metabolism were measured. The results are shown in Table 3.

[0045] Table 2 Water maze experiment results

[0046]

...

Embodiment 3

[0054] Example 3: Effect of Gastrodia elata extract or composition on learning and memory impairment in mice induced by scopolamine

[0055] Animal model: scopolamine-induced learning and memory impairment in mice

[0056] Modeling, administration, and grouping: 56 male KM mice were randomly divided into 7 groups according to body weight: blank control group, model group, donepezil group, Gastrodia PN1-PN6 group, 8 mice in each group. The treatment group was given 2.5 mg / kg donepezil (dissolved in 2% Tween80+0.5% CMC-Na) and Gastrodia elata extract PN1-PN6 by intragastric administration for 10 consecutive days (the dosages are shown in Table 4). The blank control group and the model group were intragastrically given equal volumes of distilled water.

[0057] Test indicators: Morris water maze test was carried out on the 6th to 10th day. After 40 minutes of administration on the 6th to 9th day, except for the blank control group, the other groups were intraperitoneally injecte...

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Abstract

The present invention relates to use of a rhizoma gastrodiae extract or composition in preparing a drug for dementia prevention and treatment. The extract or composition is prepared by separating from traditional Chinese medicinerhizoma gastrodiae, mainly comprises two active ingredients parishin and nucleosides, the parishin is a main ingredient, the nucleosides are a trace regulator, the ratio of parishin to ucleoside is 400:1-50:1, and the extract or composition has good anti dementia effect. The nucleosides of the extract or composition are prepared by separating from the traditional Chinese medicinerhizoma gastrodiae, the extract or composition is pure plant extract, the ratio of parishin to ucleoside is optimized on the basis of the original ratio of parishin and nucleosides naturally occurring in rhizoma gastrodiae, and the extract or composition has high acceptance and security.

Description

technical field [0001] The invention belongs to the field of natural medicines. It specifically relates to the use of a gastrodia elata extract or composition composed of two active components prepared and separated from the traditional Chinese medicine gastrodia elata in the preparation of memory-enhancing, nootropic drugs or drugs for preventing and treating diseases such as senile dementia. Background technique [0002] Senile dementia is a common and frequently-occurring disease in the aging society, which seriously threatens the quality of life and life safety of patients, and also causes a heavy burden to the society. Due to its complex etiology and pathogenesis, there is no specific medicine at present. Commonly used western medicines include brain metabolism activators, cholinergic drugs, etc., which are mostly symptomatic treatments. The overall prognosis is poor, and it has side effects such as liver toxicity and headache. Traditional Chinese medicine has the char...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61K31/7076A61K31/7072A61K31/7034A61K31/194A61P25/28
Inventor 肖红斌王莉刘欣欣唐春兰程孟春
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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