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Traditional Chinese medicinal monomer composition for treating dysmenorrhea of women and application of traditional Chinese medicinal monomer composition

A monomer composition and the technology of the composition are applied in the directions of drug combinations, medical preparations containing active ingredients, antipyretics, etc., which can solve the problems of complex ingredients, adverse reactions, inconvenience in use, etc. Small, curative effect

Active Publication Date: 2015-04-15
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the traditional Chinese medicine compound medicines for the treatment of gynecological diseases have many medicinal flavors, generally at least five flavors, and as many as dozens of traditional Chinese medicines. It is clear that the material basis for the curative effect of the compound is not clear, and there are some problems such as adverse reactions

Method used

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  • Traditional Chinese medicinal monomer composition for treating dysmenorrhea of women and application of traditional Chinese medicinal monomer composition
  • Traditional Chinese medicinal monomer composition for treating dysmenorrhea of women and application of traditional Chinese medicinal monomer composition
  • Traditional Chinese medicinal monomer composition for treating dysmenorrhea of women and application of traditional Chinese medicinal monomer composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Accurately weigh 10g of tetrahydropalmatine, 30g of salvianolic acid B, 30g of triterpenic acid I and 30g of tyrosin and mix them uniformly to obtain final product.

Embodiment 2-6

[0018] The weight ratio of four traditional Chinese medicine monomers is as follows:

[0019] (％) Example 2 Example 3 Example 4 Example 5 Example 6 Tetrahydropalmatine 10 40 30 30 60 Salvianolic acid B 20 30 40 30 20 Wulingzhi triterpene acid I 20 20 20 20 10 Typhanoside 50 10 10 20 10

[0020] The pharmacodynamics test of the Chinese medicine monomer composition prepared by embodiment 8 embodiment 1-6

[0021] Take non-pregnant female SD rats, take out the uterus by laparotomy after anesthesia, peel off the fat and connective tissue on the uterine wall, and place the uterus in an isolated organ apparatus filled with Loke's solution (through 5% O 2 , 95% CO 2 ), one end is fixed, and the other end is fixed on the tension transducer, and the contraction curve is recorded through the biological function signal system, and PGF with a final concentration of 1 μM / L is added after stabilization 2α Uterine contraction wa...

Embodiment 10

[0037] Example 10 tablet

[0038] prescription

[0039]

[0040] Preparation process: Mix four kinds of traditional Chinese medicine monomer compounds evenly, fully mix with pregelatinized starch and cross-linked carboxymethyl cellulose sodium, make soft material with 10% starch pulp, granulate with 18 mesh sieve, dry at 60°C, 16 mesh Sieve the whole grain, add magnesium stearate, mix well, and press into tablets.

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Abstract

The invention relates to a traditional Chinese medicinal monomer composition for treating dysmenorrhea of women and application of the traditional Chinese medicinal monomer composition. The traditional Chinese medicinal monomer composition consists of the following components in percentage by weight: 10 to 60 percent of tetrahydropalmatine, 10 to 60 percent of salvianolic acid B, 10 to 60 percent of trogopterus dung triterpenic acid I and 10 to 60 percent of typhaneoside. The invention also provides the application of the traditional Chinese medicinal monomer composition, namely, the application of the traditional Chinese medicinal monomer composition in preparation of a medicament for treating the dysmenorrhea of the women. The traditional Chinese medicinal monomer composition disclosed by the invention has the advantages that active substances are clear, the treatment effect is exact, the side effect is low, and the traditional Chinese medicinal monomer composition is convenient to take.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine monomer composition for treating women's primary dysmenorrhea and its application. Background technique [0002] Dysmenorrhea refers to a gynecological disease in which women experience periodic lower abdominal pain during or before and after menstruation, accompanied by other discomforts, which affect work and life. The incidence rate of dysmenorrhea among women in my country is 33.19%, which is a common and frequently-occurring disease in gynecology. Dysmenorrhea is divided into two types: primary and secondary. Primary dysmenorrhea refers to dysmenorrhea without organic lesions in the genitals, and it mostly occurs in adolescence. Its pathological mechanism may be related to prostaglandins in the endometrium, and the content of prostaglandins in the endometrium and blood of dysmenorrhea patients is higher than that of nor...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P15/00A61P29/00A61K31/4375A61K31/343
Inventor 肖军平吴永忠毛金娣陈梁李小锋
Owner JIANGXI POZIN PHARMA
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