Traditional Chinese medicine composition for treating diabetes ulcer and preparation method of traditional Chinese medicine composition

A technique for diabetic ulcers and compositions, which is applied in the field of traditional Chinese medicine compositions for treating diabetic ulcers and its preparation, can solve the problems of poor prognosis, unclear development process, and no effective treatment methods, and achieve obvious effects, convenient use, The effect of simple preparation method

Active Publication Date: 2015-06-17
常柏
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0004] The pathogenesis of diabetic ulcers is very complex and the prognosis is poor
At present, its occurrence mechanism and development process are not very clear. It is generally believed that it is related to endogenous changes in diabetes such as nerves, blood vessels, immunity, and metabolism, and exogenous factors such as infection, trauma, and pressure, and their mutual influence. There is no effective treatment.

Method used

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  • Traditional Chinese medicine composition for treating diabetes ulcer and preparation method of traditional Chinese medicine composition

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Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1, the preparation of Chinese medicine composition

[0042] According to the proportioning in Table 1, Angelica sinensis, Angelica dahurica, Comfrey and Radix Glycyrrhizae are mixed and extracted with sesame oil, the extract is collected, white wax is added to the extract and mixed to make a traditional Chinese medicine composition. The specific operations are as follows:

[0043] According to the ratio in Table 1, mix angelica, angelica dahurica, comfrey and licorice, soak them in sesame oil for 24 hours, fry them slowly over medium heat until the medicine turns yellow, filter with gauze, collect the filtrate, add white wax to the filtrate, Mix to obtain Chinese medicine composition A, Chinese medicine composition B and Chinese medicine composition C.

[0044] Table 1, the composition of raw materials of different traditional Chinese medicine compositions (unit: g)

[0045]

Embodiment 2

[0046] Embodiment 2, the effect of Chinese medicine composition A, Chinese medicine composition B and Chinese medicine composition C in the treatment of diabetic ulcer

[0047] The objects of the following experiments in this embodiment are all male Wistar rats (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) of specific pathogen-free grade (SPF grade, specific pathogen-free). Feed, the feeding conditions are that the ambient temperature is 22-25 ° C, the humidity is 55 ± 5%, 12 hours of light and 12 hours of darkness cycle per day (lighting time is 7:00-19:00 every day), free access to food and drinking water, and the place of feeding is SPF level animal breeding room of the Experimental Animal Center of the Institute of Radiological Medicine, Chinese Academy of Medical Sciences.

[0048] The feed described in the present embodiment is as follows:

[0049] Standard feed: purchased from Beijing Weitong Lihua Experimental Animal Technology Co., L...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetes ulcer and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is the traditional Chinese medicine composition for external use. The traditional Chinese medicine composition is prepared by a conventional method comprising the following steps of compounding traditional Chinese medicine raw materials of Chinese angelica, angelica dahurica, lithospermum and licorice roots in a certain proportion, extracting and refining the compounded traditional Chinese medicine raw materials and adding preparation adjuvants. Experiments prove that the traditional Chinese medicine composition provided by the invention can obviously increase the heal rate of diabetes rat ulcer and obviously improve the pathology structure of the diabetes rat ulcer, and the mechanism of the traditional Chinese medicine composition is relevant to the improvement on expression quantity ofInsulin-Like growth factor -1 receptors,epidermal growth factors andalkaline fibrocyte forming growth factorsinnew granulation tissues at the ulcer. The invention provides an effective treatment medicine for external use for treating the diabetes ulcer.

Description

technical field [0001] The invention relates to the medical field, in particular to a traditional Chinese medicine composition for treating diabetic ulcers and a preparation method thereof. Background technique [0002] With the rapid change of social life style, the incidence of diabetes with type 2 diabetes (T2DM) as the main body has risen sharply. The incidence of diabetes in my country was 1.0% in 1976, 2.0% in 1989, and 3.2% in 1996. The English Journal of Medicine further published an article pointing out that the overall prevalence of diabetes among people over the age of 20 in my country is 9.7%. From this, it is estimated that the total number of people with diabetes in the country is about 92 million, which is the fastest growing number of diabetes patients in the world. One of the fastest countries. [0003] Diabetic refractory ulcer is the main cause of amputation and disability in diabetic patients. With the increase in the number of diabetic patients worldwide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P3/10A61P17/02
Inventor 常柏李巧芬甄仲
Owner 常柏
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