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Premenstrual calming tablet and preparation process thereof

A technology for premenstrual pills and premenstrual syndrome, applied in the field of traditional Chinese medicine, can solve the problems of unclear real cause and poor curative effect, and achieve the effects of remarkable and reliable curative effect, mild medicinal properties and low cost.

Active Publication Date: 2015-07-01
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine treatment, because the real cause of premenstrual tension disorder is unclear, so symptomatic treatment, psychological or spiritual therapy, correction of salt and water imbalance and other methods are often adopted, and the curative effect is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A premenstrual tablet for premenstrual syndrome, which is prepared from the following raw materials in weight ratio:

[0026] 50 parts of Bupleurum, 50 parts of Citrus aurantium, 45 parts of dried ginger, 45 parts of turmeric, 45 parts of Cyperus,

[0027] 40 parts of green skin, 40 parts of Passepartout, 40 parts of orange core, 40 parts of angelica, 40 parts of white peony,

[0028] 35 parts of Chuanxiong, 30 parts of Poria cocos, 30 parts of Dabupi, 30 parts of licorice, 30 parts of safflower,

[0029] Dendrobium 28 parts, Moutan bark 28 parts, Wangbuliuxing 25 parts, Suanzaoren 25 parts, Achyranthes bidentata 25 parts,

[0030] 20 parts of mulberry, 20 parts of medlar, 20 parts of comfrey, 20 parts of pepper, 20 parts of dandelion,

[0031] Codonopsis 15 parts, Sijiqing 15 parts, plantain seed 15 parts, raspberry 15 parts, cinnamon 15 parts.

[0032] The preparation method of above-mentioned premenstrual safety tablet is:

[0033] Take by weighing above-mentione...

Embodiment 2

[0039] Toxicity test:

[0040] In this experiment, healthy SD rats were used, and the dosage gradient of the drug prepared in Example 1 was administered orally at 0.05g / kg and 0.5g / kg, and the drug was administered continuously for 30 days. Animal growth status, activity diet, hematology, blood biochemistry, organ tissue structure and urine routine were not significantly affected, indicating that the clinical medication is safe and reliable.

[0041] Analgesic experiment:

[0042] The effect on the writhing reaction induced by acetic acid in BALB / c mice: 60 BALB / c mice, half male and half male, with an average body weight of 22g, were randomly divided into 3 groups, namely the normal saline group, the drug group of Example 1, and the control group Drug group (Jingqian'an tablets, 0.37g / sheet, Dongguan Asia Pharmaceutical Co., Ltd.); administration twice a day, each dosage is 0.1g / kg (medicine is given to the embodiment 1 drug group and contrast drug group respectively, physi...

Embodiment 3

[0047] Summary of clinical efficacy:

[0048] General information, drug granule of the present invention is applied to clinical observation 136 cases

[0049] Diagnostic criteria and disease classification: refer to the Ministry of Health of the People's Republic of China. Guidelines for Clinical Research of New Chinese Medicines for Premenstrual Tension Syndrome. 1997.1-2. Formulate and refer to "Guidelines for Clinical Research of New Chinese Medicines for Treatment of Premenstrual Tension Syndrome". ① Mild: Slight headache, dizziness, swollen breasts, or a little pain, restlessness, sallow face, work and study as usual. ② Moderate: dizziness and headache, breast swelling, upset and insomnia, nervousness or depression, swollen limbs, still able to work and study. ③Severe: Severe and unbearable headache, dizziness, blurred vision, palpitations and insomnia, breast tenderness, inability to touch clothes, swelling of face, limbs or whole body, no point to touch, or weight gain...

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PUM

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Abstract

The invention relates to a premenstrual calming tablet and a preparation process thereof. The preparation is mainly prepared from the following raw materials: radix bupleuri, fructus aurantii, rhizoma zingiberis, radix curcumae, rhizoma cyperi, pericarpium citri reticulatae viride, liquidambar formosana hance, tangerine seed, Chinese angelica, white paeony root, ligusticum wallichii, poria cocos, pericarpium arecae, liquorice and the like which are prepared into the tablet according to the normal method. Based on the prior art, the premenstrual calming tablet is applied according to syndrome, and the components of the traditional Chinese medicines are matched with each other to coordinate efficiency, so that the premenstrual calming tablet is low in cost, good in treatment effect in premenstrual syndrome according to the clinical verification, and wide in application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a premenstrual tablet and a preparation process thereof. Background technique [0002] Premenstrual tension disorder, also known as premenstrual syndrome, symptoms appear 7-14 days before menstruation, and gradually increase until after menstruation, symptoms gradually disappear, and severe cases can last for a long time. The main clinical manifestations are premenstrual emotional agitation, irritability, depression, depression, sadness, breast pain, chest and hypochondrium pain, less abdominal pain or headache, or varying degrees of edema, more or less menstrual flow, dark color, tongue Quality dark, stringy pulse etc. TCM dialectics mainly belong to stagnation of qi due to stagnation of liver stagnation and stagnation of qi, and the methods of soothing the liver and regulating qi, promoting blood circulation and dredging collaterals are often effective....

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/20A61P15/00
Inventor 林凡儒杨川川赵树楷罗晓倩付君叶
Owner XIANGYU PHARMA
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