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Preparation technology for ceftazidime for injection

A technique for preparing ceftazidime, which is applied in the field of preparation of ceftazidime for injection, can solve problems such as low product yield, unstable product quality, and impurities introduced by ceftazidime, so as to increase yield, avoid drug efficacy reduction, and improve stability Effect

Inactive Publication Date: 2015-07-08
SICHUAN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by this invention is to provide a kind of preparation technology of ceftazidime for injection, to overcome the low yield of product and unstable product quality caused by the preparation technology of existing ceftazidime for injection, easy to introduce impurities in ceftazime Problems of reducing efficacy of ceftazidime preparations for injection

Method used

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Examples

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Embodiment

[0022] The preparation technology of ceftazidime for injection comprises the following steps:

[0023] (1) Synthesis of ceftazidime: using the intermediate 7-ACA as the starting material, using hexamethyldisilazane as the silyl reagent, ceftazidime pentahydrate was obtained through the 3-position substitution reaction and the 7-position acylation reaction, and then The wet product of ceftazidime is obtained through dehydration reaction, and nitrogen gas is fed into the bottom of the liquid during the synthesis process;

[0024] (2), drying and pulverizing the synthetic ceftazidime wet product into powder;

[0025] (3) The preparation process of ceftazidime: first, clean the reagent bottle used to hold ceftazidime powder. The cleaning process of the reagent bottle is ultrasonic washing, soaking in hot water at 80°C for 60 minutes, then rinsing with warm water at 25°C, and air drying , oven drying, dry heat sterilization, and then quantitatively put ceftazidime powder into the ...

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Abstract

The invention relates to preparation technology for ceftazidime for injection. The preparation technology comprises the following steps that a ceftazidime wet product is synthesized; the synthesized ceftazidime wet product is dried and crushed to be prepared to be in a powder shape. The preparation technology of ceftazidime powder comprises the steps that a reagent bottle used for containing the ceftazidime powder is washed, and the washing process of the reagent bottle sequentially comprises ultrasonic washing, 80-100 DEG C hot water soaking for 30 min-60 min, 25 DEG C warm water washing, air drying, drying oven drying and sterilizing; the ceftazidime powder is contained into the washed reagent bottle, nitrogen is filled in the reagent bottle, the reagent bottle is covered by a preprocessed rubber plug, and cover fastening processing is performed by using an aluminum cover; interior label pasting, packaging and light inspecting are sequentially performed on the fastened reagent bottle. According to the preparation technology, the problems caused by the existing preparation technology of the ceftazidime for the injection that the product yield is low, the product quality is not stable and the medicine effects of the ceftazidime for injection are reduced caused by the fact that impurities are prone to being introduced into the ceftazidime are solved.

Description

technical field [0001] The invention relates to the field of preparation technology of medical drugs, in particular to a preparation technology of ceftazidime for injection. Background technique [0002] Ceftazidime belongs to the third-generation cephalosporin antibiotics and was discovered in 1978. In 1983, it was first developed and marketed by the British Glaxo Company. In 1992, ceftazidime was listed for the first time in my country, and in 1993 it was officially included in the list of essential medicines in my country. After more than 10 years of clinical application verification, ceftazidime has the characteristics of broad antibacterial spectrum and enzyme resistance. It has strong antibacterial activity against Pseudomonas aeruginosa and is widely used to treat various moderate and severe infections. The drug of choice for patients with bacterial hazards. [0003] The chemical name of ceftazidime is: (6R,7R)-7-[[(2-amino-4-thiazolyl)-[(1-carboxy-1-methylethoxy)i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/04C07D501/06C07D501/46
CPCC07D501/04C07D501/06C07D501/46
Inventor 刘萍王强张静文
Owner SICHUAN PHARMA
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