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Injectable antibacterial hydrogels based on oligomeric amino acid amphiphiles

A technology for hydrogels and antibacterial agents, applied in the field of antibacterial hydrogels based on oligomeric amino acid amphiphilic molecules, can solve problems such as difficult to meet antibacterial requirements, achieve good application prospects, easy mass preparation, and simple and convenient preparation methods

Inactive Publication Date: 2017-09-05
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional antibacterial hydrogels are mostly prepared by mixing a single antibacterial agent with polymer materials, and its application range has certain limitations. It is difficult to meet various complicated antibacterial needs encountered in medical treatment and daily life. It is very urgent to develop an antibacterial hydrogel material with a wider spectrum of use to solve the above problems

Method used

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  • Injectable antibacterial hydrogels based on oligomeric amino acid amphiphiles
  • Injectable antibacterial hydrogels based on oligomeric amino acid amphiphiles
  • Injectable antibacterial hydrogels based on oligomeric amino acid amphiphiles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1, preparation of polyε-lysine antibacterial hydrogel coated with compound shown in formula V and its antibacterial performance test

[0070]

[0071] (1) Mix the compound represented by formula V with polyε-lysine with a molecular weight of 10,000Da according to the mass ratio of 1:0.128 and 1:0.64 respectively, and obtain a mixture of the two after mixing evenly;

[0072] (2) The mixture is completely dissolved in pure water with the mass fraction of amphiphilic molecules being 1% to obtain an aqueous solution of the mixture;

[0073] (3) Add the aqueous solution of the mixture into a petri dish and let it stand at room temperature for 1 hour, and a thin layer of hydrogel can be spontaneously formed on the bottom of the dish;

[0074] (4) Add 10 to the surface of the hydrogel 6 CFU / ml Escherichia coli, cultivated for 15 hours, by testing the OD of the corresponding sample 620nm Value characterizes the sample antibacterial rate of above 2 kinds of proporti...

Embodiment 2

[0075] Example 2, Preparation of polyε-lysine antibacterial hydrogel coated with compound shown in formula VIII and its antibacterial performance test

[0076]

[0077] (1) Mix the compound represented by formula VIII with polyε-lysine with a molecular weight of 10,000Da according to the mass ratio of 1:0.128, 1:0.64, and 1:1.28, respectively, and obtain a mixture of the two after mixing evenly;

[0078] (2) The mixture is completely dissolved in pure water with the mass fraction of amphiphilic molecules being 1% to obtain an aqueous solution of the mixture;

[0079] (3) Add the aqueous solution of the mixture into a petri dish and let it stand at room temperature for 2 hours, a thin layer of hydrogel can be spontaneously formed at the bottom of the dish;

[0080] (4) Add 10 to the surface of the hydrogel 6 CFU / ml of E. coli, cultured for 15 hours, see figure 1 , by testing the OD of the corresponding sample 620nm Value characterizes the sample antibacterial rate of abov...

Embodiment 3

[0081] Example 3, Preparation of polyε-lysine antibacterial hydrogel coated with compound shown in formula VIII and its antibacterial performance test

[0082]

[0083] (1) Mix the compound represented by formula VIII with polyε-lysine with a molecular weight of 10,000Da according to the mass ratio of 1:0.128, 1:0.64, and 1:1.28, respectively, and obtain a mixture of the two after mixing evenly;

[0084] (2) The mixture is completely dissolved in pure water with the mass fraction of amphiphilic molecules being 1% to obtain an aqueous solution of the mixture;

[0085] (3) Add the aqueous solution of the mixture into a petri dish and let it stand at room temperature for 2 hours, a thin layer of hydrogel can be spontaneously formed at the bottom of the dish;

[0086] (4) Add 10 to the surface of the hydrogel 6 CFU / ml of E. coli, cultivated for 24 hours, by testing the OD of the corresponding sample 620nm Value characterizes the sample bacteriostatic rate of above 3 kinds of ...

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Abstract

The invention discloses an antibacterial hydrogel based on oligomeric amino acid amphiphile molecules. The antibacterial hydrogel is obtained by mixing an amphiphilic compound and an antibacterial agent in a solvent and standing still; the amphiphilic compound is selected from at least one of the compounds represented by formula I, formula II, formula III and formula IV. By using the method of the invention, various antibacterial agents can be inserted into the hydrogel network through physical blending and in-situ gelation. The preparation raw materials of the antibacterial hydrogel provided by the present invention have good biocompatibility and biodegradability and low cost, the preparation method is simple and convenient, easy to prepare in large quantities, and the obtained hydrogel has the characteristics of injectability Advantages, injectable antibacterial hydrogels that meet various antibacterial needs can be prepared by changing the types of antibacterial agents coated, and have good application prospects in the fields of biomedical and daily necessities antibacterial materials.

Description

technical field [0001] The invention belongs to the field of materials and relates to an antibacterial hydrogel based on oligomeric amino acid amphiphile molecules. Background technique [0002] With the advancement of social modernization and the rapid development of the economy, human beings' requirements for quality of life continue to improve, especially the emphasis on health. The existing biomedical materials have been difficult to meet people's growing needs. At the same time, the environmental pollution caused by the rapid development of industry has become more and more serious. The air is filthy, rivers and lakes are no longer clear and bright, and various bacteria breed. These problems have seriously endangered people's healthy life. Therefore, the development of an environmentally friendly antibacterial biomaterial can protect people from various germs in daily life and medical care. [0003] Antibacterial material products can be roughly divided into two catego...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K45/00A61P31/04A61L15/28A61L15/44A61L15/42C08J3/075
Inventor 李志波万耀明王作宁
Owner QINGDAO UNIV OF SCI & TECH