Application of 4-methoxybenzyl alcohol in preparation of blood-brain barrier protective medicine

A technology of methoxybenzyl alcohol and blood-brain barrier, applied in the field of 4-methoxybenzyl alcohol in the preparation of blood-brain barrier protection drugs, can solve the problems of 4-methoxybenzyl alcohol and other problems, and achieve The effect of good protection

Active Publication Date: 2015-08-12
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical formula is: C 8 h 10 o 2 , the structural formula is At present, 4-methoxybenzyl alcohol is usually

Method used

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  • Application of 4-methoxybenzyl alcohol in preparation of blood-brain barrier protective medicine
  • Application of 4-methoxybenzyl alcohol in preparation of blood-brain barrier protective medicine
  • Application of 4-methoxybenzyl alcohol in preparation of blood-brain barrier protective medicine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental example 1 The blood-brain barrier protective effect of 4-methoxybenzyl alcohol

[0032] 1. Experimental materials

[0033] 1.1 Experimental animals

[0034] Adult healthy male SD rats, weighing 250-300g, SPF grade, provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences, production license number: SCXK (Sichuan) 2013-12, production batch number: 0016729.

[0035] 1.2 Experimental drugs

[0036] 4-methoxybenzyl alcohol was purchased from Sigma, USA.

[0037] 1.3 Experimental reagents

[0038]

[0039] 1.4 Experimental Instruments

[0040]

[0041] 1.5 Preparation of main reagents

[0042] 1.5.1 The configuration of 0.9% normal saline: 4.5g sodium chloride, add double distilled water to 500mL, shake well and put it in a 4℃ refrigerator for later use.

[0043] 1.5.2 Preparation of normal saline (0.9%) plus heparin (5 units / m1) solution: add 4.5 g of sodium chloride, add double distilled water to 500 mL, add 400 uL of ...

experiment example 2

[0088] Experimental Example 2 The protective effect of 4-methoxybenzyl alcohol on the blood-brain barrier

[0089] Blood-brain barrier (BBB), as the gateway of the brain, is the structural basis for the body to maintain the stability of the brain environment, and plays an important role in cerebral ischemia / reperfusion injury (CIRI). At present, there are many factors affecting BBB damage, and its molecular mechanism is intricate. CIRI causes BBB damage and increased permeability. The main mechanisms are: increased expression of matrix metalloproteinases (MMPs); The tight junction (TJ) between vascular endothelial cells is opened, the main structural proteins (Occludin, Claudin-5) are degraded; the free radical damage, the cytotoxicity caused by the excessive accumulation of NO; ​​the common result of the interaction of various factors such as inflammatory response, is A multifactorial complex pathological process usually involves the interaction of multiple factors and multip...

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Abstract

The invention discloses application of 4-methoxybenzyl alcohol in the preparation of a blood-brain barrier protective medicine. Research of the invention shows that the 4-methoxybenzyl alcohol helps reduce blood-brain permeability in the process of cerebral ischemia, reduce expressions of brain tissues, NO, iNOS and nNOS, reduce high expression of AQP4 protein and reduce the TJ major structural proteins, Occludin and Claudin-5; the cerebral ischemia can well protect the blood-brain barrier, can be made into the blood-brain barrier protective medicine and has promising clinical application prospect.

Description

technical field [0001] The invention relates to the use of 4-methoxybenzyl alcohol in the preparation of blood-brain barrier protection drugs. Background technique [0002] The blood-brain barrier (BBB) ​​was discovered by German bacteriologist Pau1 Ehrhch. It is a physiological barrier between blood and brain tissue and plays an important role in maintaining the stability of the brain environment. The blood-brain barrier plays a strict screening role in the material exchange process between blood and brain interstitial fluid. Under physiological conditions, the blood-brain barrier is relatively impermeable and mainly functions as a barrier. It can also selectively pump harmful or excess substances in the brain. Keep the internal environment of the brain stable. [0003] The destruction of the blood-brain barrier in the process of cerebral ischemic injury is an important pathological change of cerebral edema and cerebral infarction induced by cerebral ischemia. . After ce...

Claims

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Application Information

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IPC IPC(8): A61K31/085A61P9/00A61P25/00A61P9/10
Inventor 段小花林青何芳雁
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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