Calcium alginate/hydroxyapatite nanocomposite dual-loaded porous scaffold containing biodegradable polyester microspheres and preparation method thereof

A technology for hydroxyapatite and polyester degradation, applied in medical science, prostheses, etc., can solve the problems of difficult removal of catalysts and residual monomers, and limit the application of porous scaffold materials, so as to maintain the biological activity of drugs and improve the quality of drugs. The effect, the effect of controllable preparation conditions

Inactive Publication Date: 2017-03-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the continuous phase of immobilized Pickering emulsion often involves the polymerization of monomers, and it is difficult to remove the catalyst and residual monomers in the product, which limits the application of the prepared porous scaffold materials in biomedical fields such as drug controlled release.
In addition, based on the Pickering emulsion template and does not require any chemical reaction to immobilize the emulsion continuous phase, the porous scaffold biomaterial containing microspheres is conveniently prepared and used as a dual drug carrier. So far, there has been no corresponding report.

Method used

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  • Calcium alginate/hydroxyapatite nanocomposite dual-loaded porous scaffold containing biodegradable polyester microspheres and preparation method thereof
  • Calcium alginate/hydroxyapatite nanocomposite dual-loaded porous scaffold containing biodegradable polyester microspheres and preparation method thereof

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Effect test

Embodiment 1

[0037] A method for preparing a calcium alginate / hydroxyapatite nanocomposite dual-loaded porous scaffold containing biodegradable polyester microspheres, the specific preparation steps are as follows:

[0038] (1) Add 100 mg of polylactic acid and 10 mg of ibuprofen into 3 mL of dichloromethane, and ultrasonically dissolve the polylactic acid and ibuprofen in an ice-water bath to prepare an oil phase;

[0039] (2) The molecular weight of 180mg is 1.2×10 5 g / mol sodium alginate and 9 mg bovine serum albumin were dissolved in 9 mL distilled water, then 180 mg hydroxyapatite nanoparticles were added, magnetically stirred for 0.5 hours to disperse the particles evenly, then 100 mg gluconolactone was added, and the gluconic acid The lactone is dissolved and prepared to obtain an aqueous phase;

[0040] (3) Add the oil phase obtained in step (1) to the water phase obtained in step (2), and the oil-water mixed system is emulsified by a high-speed shearing machine at a speed of 1200...

Embodiment 2

[0044] A method for preparing a calcium alginate / hydroxyapatite nanocomposite dual-loaded porous scaffold containing biodegradable polyester microspheres, the specific preparation steps are as follows:

[0045] (1) Add 90 mg polylactic acid-glycolic acid copolymer and 9 mg ibuprofen into 3 mL of dichloromethane, and ultrasonically dissolve the polylactic acid-glycolic acid copolymer and ibuprofen in an ice-water bath to prepare an oil phase;

[0046] (2) The molecular weight of 180mg is 1.2×10 5 g / mol of sodium alginate and 18 mg of bovine serum albumin were dissolved in 9 mL of distilled water, then 270 mg of hydroxyapatite nanoparticles were added, magnetically stirred for 0.5 hours to disperse the particles evenly, then 200 mg of gluconolactone was added, and the gluconic acid The lactone is dissolved and prepared to obtain an aqueous phase;

[0047] (3) Add the oil phase obtained in step (1) to the water phase obtained in step (2), and the oil-water mixed system is emulsi...

Embodiment 3

[0051] A method for preparing a calcium alginate / hydroxyapatite nanocomposite dual-loaded porous scaffold containing biodegradable polyester microspheres, the specific preparation steps are as follows:

[0052] (1) Add 270 mg of polylactic acid and 0.3 mg of paclitaxel into 3 mL of dichloromethane, dissolve the polylactic acid and paclitaxel completely under the action of ultrasound, and prepare an oil phase;

[0053] (2) The molecular weight of 100mg is 5×10 5 g / mol of sodium alginate and 0.2mg of transforming growth factor (TGFβ) were dissolved in 10mL of distilled water, then 300mg of hydroxyapatite nanoparticles were added, and magnetically stirred for 0.5 hours to disperse the particles evenly, then 200mg of gluconolactone was added, and quickly Stir to dissolve the gluconolactone and prepare the water phase;

[0054] (3) The oil phase obtained in step (1) is added to the water phase obtained in step (2), and the oil-water mixed system is emulsified by a high-speed shear...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a calcium alginate / hydroxyapatite nano compound double drug loading porous scaffold containing biodegradable polyester microspheres and a preparation method thereof. The preparation method comprises following preparation steps: biodegradable polyesters and hydrophobic drugs are added into organic solvents to dissolve and are prepared to obtain an oil phase, calcium alginate and hydrophilic drugs are dissolved in distilled water, then hydroxyapatite nanoparticles are added to uniformly disperse, and then glucolactone is added, and is stirred to dissolve and prepare to obtain a water phase. The oil phase is added into the water phase, and the oil phase and the water phase are mixed to form oil-in water emulsion by emulsifying. The oil-in water emulsion is frozen and dried after being placed in room temperature for 8-24 hours, thereby preparing the calcium alginate / hydroxyapatite nano compound double drug loading porous scaffold containing the biodegradable polyester microspheres. The preparation method is simple in operation, mild in preparation conditions and low in demands for equipment, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a calcium alginate / hydroxyapatite nanocomposite double-loaded porous scaffold containing biodegradable polyester microspheres and a preparation method thereof. Background technique [0002] Drug controlled release technology is a drug delivery technology that combines drugs with controlled release carriers through physical or chemical means, so that drugs can be released continuously and slowly at specific sites in the form of diffusion and penetration. This drug delivery technology is conducive to enhancing drug stability, prolonging drug action time, improving drug efficacy, reducing drug cost, and reducing drug side effects. It is of great significance for solving the problems of high efficiency and safety of clinical drug use. One of the research hotspots in the field of biomedicine. Drug controlled release carriers play a role in loading, protecting...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/52A61L27/54A61L27/56A61L27/58
Inventor 王朝阳胡洋马杉杉杜郑珊杨宇
Owner SOUTH CHINA UNIV OF TECH
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