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Method for determining sulfur dioxide in amygdalin contained traditional Chinese medicine and slices thereof

A technology of sulfur dioxide and amygdalin is applied in chemical instruments and methods, measuring devices, containers for laboratory use, etc., and can solve the problems of inability to accurately determine the content of sulfur dioxide in traditional Chinese medicines and their decoction pieces, excessive sulfur dioxide, etc. The effect of improving accuracy

Active Publication Date: 2015-08-26
四川省中药饮片有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the process of daily quality inspection of Chinese medicinal materials, the inventor unexpectedly found that the residual sulfur dioxide in Chinese medicinal materials and their decoction pieces was determined according to the method under Appendix IXU Sulfur Dioxide Residue Detection Method of the 2010 Edition of the Chinese Pharmacopoeia and calculated according to the consumption of iodine solution. The unsulphur-fumigated bitter almonds, plum kernels, peach kernels, and peach kernels taken from fresh peach pits all have serious excess sulfur dioxide, which proves that conventional pharmacopoeia methods cannot accurately determine the sulfur dioxide content of the above traditional Chinese medicines and their decoction pieces

Method used

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  • Method for determining sulfur dioxide in amygdalin contained traditional Chinese medicine and slices thereof
  • Method for determining sulfur dioxide in amygdalin contained traditional Chinese medicine and slices thereof
  • Method for determining sulfur dioxide in amygdalin contained traditional Chinese medicine and slices thereof

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Effect test

Embodiment 1

[0047] The screening test of Y value among the formula I of the present invention in embodiment 1

[0048] The present invention compares the "distillation-iodometric method" of the Pharmacopoeia and the "distillation-silver nitrate-iodometric method" of the present invention to measure the sulfur dioxide content in bitter almonds by headspace gas chromatography-flame photometry, and the Y value in the formula I of the present invention Perform a screening test. Wherein, a, b are both 10g, M(SO2)=64.04g / moL; na, nb and nc are calculated by corresponding titration.

[0049] 1 Instruments and reagents

[0050] Timi GC7900 gas chromatograph, flame photometric detector (FPD), Agilent 7694E headspace sampler, SPB-3 air generator, pipette gun, sulfur dioxide standard solution, 0.1g / L formaldehyde absorption solution, hydrochloric acid, sodium hydroxide , anhydrous sodium sulfite, iodine titration solution (concentration is 0.010036mol / L), silver nitrate titration solution (concent...

Embodiment 2

[0074] Embodiment 2 The inventive method measures the sulfur dioxide content in the bitter almond

[0075] The devices used in the following determination methods are the devices under Appendix IX U Sulfur Dioxide Residue Detection Method of "Chinese Pharmacopoeia" 2010 Edition, and nitrogen environment is maintained during the determination steps.

[0076] (1) Sampling: Take two parts of bitter almond powder, one part weighs 10.0016g as sample A, and the other part weighs 10.0009g as sample B;

[0077] (2) Measure the iodine consumption of sample A: add 300 mL of water and 10 mL of 6mol / L hydrochloric acid to sample A, heat to boiling, absorb the escaped gas with 120 mL of water, keep stirring, and obtain titration solution A2 after 30 min; Adopt iodometric titration, the concentration of iodine titration solution is 0.0100mol / L, 1mL of 0.5% starch solution is used as indicator, until the titration solution A2 shows blue or blue purple and lasts for 30 seconds and does not co...

Embodiment 3

[0083] Embodiment 3 The inventive method measures the sulfur dioxide content in the peach kernel

[0084] The devices used in the following determination methods are the devices under Appendix IX U Sulfur Dioxide Residue Detection Method of "Chinese Pharmacopoeia" 2010 Edition, and nitrogen environment is maintained during the determination steps.

[0085] (1) Sampling: Take two parts of peach kernel powder, one part weighs 5.0509g as sample A, and the other part weighs 5.0609g as sample B;

[0086] (2) Measure the iodine consumption of sample A: add 300 mL of water and 10 mL of 6mol / L hydrochloric acid to sample A, heat to boiling, absorb the escaped gas with 120 mL of water, keep stirring, and obtain titration solution A2 after 30 min; Adopt iodometric titration, the concentration of iodine titration solution is 0.0010mol / L, 5mL of 0.1% starch solution is used as indicator, until the titration solution A2 shows blue or blue purple and lasts for 30 seconds and does not comple...

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Abstract

The invention discloses a method for determining sulfur dioxide in amygdalin contained traditional Chinese medicine and slices thereof. An interference value of an iodometric method is eliminated due to the combination of the iodometric method and a silver nitrate titration method and namely that a difference value of the sulfur dioxide content which is determined by a titration method and the sulfur dioxide content which is determined through headspace gas chromatography and flame photometry is reduced to be within 2 milligrams every kilogram from 370 milligrams every kilogram. The method is simple and convenient, rapid and accurate.

Description

technical field [0001] The invention relates to the field of quality detection of traditional Chinese medicines, in particular to a method for measuring sulfur dioxide in traditional Chinese medicines containing amygdalin and decoction pieces thereof. Background technique [0002] In the traditional Chinese medicine production industry, in order to make the appearance and color of Chinese medicine and its decoction pieces look good, and at the same time prevent mildew and insects, many Chinese medicines are treated with sulfur fumigation. In recent years, studies have shown that excessive sulfur dioxide residues in traditional Chinese medicines will cause harmful effects on the human body. In view of this, the State Pharmacopoeia Committee has formulated a sulfur dioxide limit standard in the second supplement of the 2010 edition of the "Chinese Pharmacopoeia", stipulating that 10 kinds of traditionally used sulfur dioxide such as yam Except for the fumigated Chinese herbal ...

Claims

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Application Information

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IPC IPC(8): G01N21/78G01N30/88B01L3/00
Inventor 孟杰王礼均朱文俊黄国杰
Owner 四川省中药饮片有限责任公司
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