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Superparamagnetic nano-particle and preparation method and application thereof

A superparamagnetic and nanoparticle technology, applied in the field of nanomedicine, can solve the problems of inability to separate the particle nucleation stage from the growth stage, poor monodispersity of product particles, etc., to achieve improved stability and biocompatibility, and small particle size , the effect of small particle size

Inactive Publication Date: 2015-09-23
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, using citric acid to modify magnetic iron oxide to prepare superparamagnetic iron oxide can improve the water solubility of superparamagnetic iron oxide, which is convenient for biological application. At present, it is generally prepared by co-precipitation method. The co-precipitation method is to use two The aqueous solution of valent iron and ferric compound is mixed with the aqueous solution of citric acid, heated for reaction, and then added with a strong alkali solution for reaction to obtain superparamagnetic nanoparticles of iron ferric oxide. This method cannot separate the nucleation stage and the growth stage of the particles, resulting in The product particles have poor monodispersity

Method used

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  • Superparamagnetic nano-particle and preparation method and application thereof
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  • Superparamagnetic nano-particle and preparation method and application thereof

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Embodiment 1

[0055] In this embodiment, the superparamagnetic contrast agent of the present invention is prepared by the following method, which includes the following steps:

[0056] (1) Under nitrogen protection, 1g FeSO 4 ·7H 2 O and 2g FeCl 3 ·6H 2 O was dissolved in a three-neck flask with 40 mL of distilled water to form a solution a with a concentration of ferrous iron compound of 25 mg / mL and a concentration of ferric iron compound of 50 mg / mL;

[0057] (2) Add 30 mL of sodium hydroxide solution with pH=14 dropwise to solution a at a rate of 30 drops / min, and react at 55° C. for 30 min under nitrogen protection with mechanical stirring at 1000 rpm to obtain solution b;

[0058] (3) Under nitrogen protection, dropwise add 4 mL of an aqueous solution of citric acid with a concentration of 50 mg / mL to solution b at a rate of 50 drops / min, and react at 90° C. for 30 min under stirring at 1000 rpm to obtain solution c;

[0059] (4) washing the solution c with alcohol, separating wit...

Embodiment 2

[0072] In this embodiment, the superparamagnetic contrast agent of the present invention is prepared by the following method, which includes the following steps:

[0073] (1) Under nitrogen protection, 1.2g FeCl 2 and 4.6g iron nitrate Fe(NO 3 ) 3 Dissolve in a three-necked flask filled with 100mL of distilled water to form a solution a with a ferrous compound concentration of 12mg / mL and a ferric compound concentration of 46mg / mL;

[0074] (2) Add 80 mL of sodium hydroxide solution with pH=14 dropwise to solution a at a rate of 20 drops / min, and react at 60°C for 50 min under nitrogen protection with mechanical stirring at 800 rpm to obtain solution b;

[0075] (3) Under nitrogen protection, add 2 mL of an aqueous solution of sodium citrate with a concentration of 90 mg / mL dropwise to solution b at a rate of 80 drops / min, and react at 80° C. for 1 h under stirring at 1000 rpm to obtain solution c ;

[0076] (4) washing the solution c with alcohol, separating with a magnet...

Embodiment 3

[0080] In this embodiment, the superparamagnetic contrast agent of the present invention is prepared by the following method, which includes the following steps:

[0081] (1) Under nitrogen protection, 0.4g FeCl 2 and 1.2g iron oxalate and 0.5g FeCl 3 The mixture was dissolved in a three-necked flask with 40 mL of distilled water to form a solution a with a ferrous compound concentration of 10 mg / mL and a ferric compound concentration of 42.5 mg / mL;

[0082] (2) Add 260mL of ammonia water with pH=13 dropwise to solution a at a rate of 50 drops / min, and react at 55°C for 1 hour under nitrogen protection with mechanical stirring at 1500 rpm to obtain solution b;

[0083] (3) Under the protection of nitrogen, add 1 mL of an aqueous solution of disodium citrate with a concentration of 50 mg / mL dropwise to solution b at a rate of 50 drops / min, and react at 95°C for 40 min under stirring at 1500 rpm to obtain solution c ;

[0084] (4) washing the solution c with alcohol, separating...

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Abstract

The invention provides a superparamagnetic nano-particle, a preparation method of the superparamagnetic nano-particle and application of the superparamagnetic nano-particle. A ferrous compound and a ferric compound are reacted with an aqueous alkali, a water-soluble citrate compound serves as a modifier, and the ferroferric oxide superparamagnetic nano-particle with the surface wrapped by the water-soluble citrate compound is obtained by a co-precipitation method. A nucleating stage and a growing stage of ferroferric oxide particles are effectively separated, and the superparamagnetic nano-particle which is small and uniform in particle size and good in dispersibility is obtained; the water-soluble citrate compound is used for modifying the surfaces of the ferroferric oxide nano particles, so that the stability and the biocompatibility of the superparamagnetic nano-particle in a human body are improved. A stable dispersion system is formed by dispersing the superparamagnetic nano-particle in an aqueous solution, a superparamagnetic contrast agent is obtained, and the contrast agent can perform magnetic resonance imaging in a pathological tissue of myocardial infarction.

Description

technical field [0001] The invention belongs to the field of nanomedicine, and relates to a superparamagnetic nanoparticle, a preparation method and application thereof, and a superparamagnetic contrast agent prepared from the superparamagnetic nanoparticle, and a preparation method and application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) is a technology that uses a magnetic field and radio frequency pulses to precess the proton nuclei in human tissue to generate radio frequency signals, which are processed by a computer to draw a structural image inside the object. Compared with other imaging methods, MRI has the following three advantages: 1. It has excellent resolution for soft tissues; 2. Various parameters can be used for imaging, and multiple imaging parameters can provide rich diagnostic information; 3. For the human body No ionizing radiation damage. In the gradual research process, it was found that the overlapping relaxation times of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18
Inventor 张欣代凤英胡冰冰
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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