Superparamagnetic nano-particle and preparation method and application thereof

A superparamagnetic and nanoparticle technology, applied in the field of nanomedicine, can solve the problems of inability to separate the particle nucleation stage from the growth stage, poor monodispersity of product particles, etc., to achieve improved stability and biocompatibility, and small particle size , the effect of small particle size
CN104922702AInactive Publication Date: 2015-09-23INST OF PROCESS ENG CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PROCESS ENG CHINESE ACAD OF SCI
Publication Date
2015-09-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a superparamagnetic nano-particle, a preparation method of the superparamagnetic nano-particle and application of the superparamagnetic nano-particle. A ferrous compound and a ferric compound are reacted with an aqueous alkali, a water-soluble citrate compound serves as a modifier, and the ferroferric oxide superparamagnetic nano-particle with the surface wrapped by the water-soluble citrate compound is obtained by a co-precipitation method. A nucleating stage and a growing stage of ferroferric oxide particles are effectively separated, and the superparamagnetic nano-particle which is small and uniform in particle size and good in dispersibility is obtained; the water-soluble citrate compound is used for modifying the surfaces of the ferroferric oxide nano particles, so that the stability and the biocompatibility of the superparamagnetic nano-particle in a human body are improved. A stable dispersion system is formed by dispersing the superparamagnetic nano-particle in an aqueous solution, a superparamagnetic contrast agent is obtained, and the contrast agent can perform magnetic resonance imaging in a pathological tissue of myocardial infarction.
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Description

technical field

[0001] The invention belongs to the field of nanomedicine, and relates to a superparamagnetic nanoparticle, a preparation method and application thereof, and a superparamagnetic contrast agent prepared from the superparamagnetic nanoparticle, and a preparation method and application thereof. Background technique

[0002] Magnetic Resonance Imaging (MRI) is a technology that uses a magnetic field and radio frequency pulses to precess the proton nuclei in human tissue to generate radio frequency signals, which are processed by a computer to draw a structural image inside the object. Compared with other imaging methods, MRI has the following three advantages: 1. It has excellent resolution for soft tissues; 2. Various parameters can be used for imaging, and multiple imaging parameters can provide rich diagnostic information; 3. For the human body No ionizing radiation damage. In the gradual research process, it was found that the overlapping relaxation times of...

Claims

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