Post-loading method of zeolite-doped plastics with antimicrobial metal ions

An anti-microbial, metal ion technology, applied in the direction of drug combination, anti-infective drugs, medical science, etc., can solve problems such as products failing to pass the test

Active Publication Date: 2018-09-14
DIFUSION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The [0032] reaction catalyzed by silver while incorporating silver zeolite into PEEK has the potential to produce toxic materials at elevated temperatures that could cause the product to fail these tests

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] A natural or synthetic ion-exchanged zeolite (eg, type A or type X zeolite) commercially available from W.R. Grace & Co. - Conn., or an equivalent thereof, is incorporated into the PEEK. Typical amounts of zeolite particles incorporated into the implant resin range from 0.01 to 10% by weight, more preferably from 0.01 to 8.0% by weight, most preferably from 0.1 to 5.0% by weight. The method for coating the implant is not particularly limited and may include spraying, painting or dipping. When blending into PEEK, for example, the PEEK composite should be protected from sources of moisture and contamination. Mixing can be performed by blending.

[0100] About 5% by weight of the zeolite powder is thoroughly mixed with the powdered or granulated PEEK. The mixture was brought to a temperature of 400°C and processed at 400°C using high shear. Zeolites and PEEK must be dry before processing to minimize decomposition and void formation in the product.

[0101] This system ...

Embodiment 2

[0105] Example 2 - Loading of finished pieces with antimicrobial metal ions

[0106] The final part fabricated as described in Example 1 was dipped in the impregnation solution in order to load the part with antimicrobial metal ions.

[0107] A typical solution for impregnation is prepared by adding 2% silver nitrate, 5% copper nitrate trihydrate, and 1% nitric acid to purified water.

[0108] Component Composition (W / W)%

[0109] Silver nitrate 2

[0110] Copper nitrate trihydrate 5

[0111] nitric acid 1

[0112] Purified water 92

[0113] Total 100

[0114] The final part is supported or allowed to move freely in the dipping solution. The solution should be stirred to enhance ion diffusion to and from the composite surface. Reasonably, the dipping process is performed in the dark to minimize photo-oxidation of the silver in solution. This can be influenced on a lab scale by placing an opaque lid, such as a tin can, over the beaker in which the parts are soaked.

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Abstract

A method of postloading ceramic particles with antimicrobial metal cations is disclosed. In certain embodiments, the post-loaded particle is a zeolite, wherein the zeolite has been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer, such as polyaryl ether ether ketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in the zeolite. Disclosed in certain embodiments are methods of imparting antimicrobial activity to the device by controlling the delivery of certain cations by ion exchange via zeolites incorporated into the device.

Description

[0001] The application number is 201080062338.X (international application number is PCT / US2010 / 058009), the application date is November 24, 2010, and the title of the invention is "Post-loading of zeolite-doped plastics with antimicrobial metal ions" divisional application of the Chinese patent application. [0002] This application for patent claims priority to U.S. Provisional Application Serial No. 61 / 264,289, filed November 25, 2009, and U.S. Provisional Application Serial No. 61 / 300,631, filed February 2, 2010, to the The disclosure is incorporated herein. field of invention [0003] The present invention relates to a method of postloading zeolite-doped plastics with antimicrobial metal ions. Background technique [0004] Implantable medical devices are implanted in the body for a variety of reasons, including orthopedic (eg, hip replacement, spinal procedures, knee replacement, fracture repair, etc.). Given the structural integrity requirements of such devices, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/10A61L27/54
CPCA61L27/446A61L2300/404A61L27/10A61L27/54A61P31/00C08L71/00A61L27/18A61L27/443A61L27/56A61L2202/21A61L2300/104C08L71/12
Inventor J.J.克鲁登D.约翰斯
Owner DIFUSION TECH
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