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Traditional Chinese medicine preparation for treating scleroderma and preparation method of traditional Chinese medicine preparation

A traditional Chinese medicine preparation, scleroderma technology, applied in skin diseases, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory therapy, and achieve guaranteed efficacy, high cure rate, and good therapeutic effect. Effect

Inactive Publication Date: 2015-10-07
QINGDAO LANSHENGYANG PHARMA & BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, it was considered to be a collagen disease, but now it is considered to be an autoimmune disease, and there is no satisfactory treatment so far

Method used

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  • Traditional Chinese medicine preparation for treating scleroderma and preparation method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating scleroderma and preparation method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating scleroderma and preparation method of traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] In order to prove the feasibility of the traditional Chinese medicine composition and preparation method of the present invention, and to provide test medicines for subsequent tests, the inventor carried out several actual production operations of formula ratios. The inventor has selected the boundary value, arbitrary value and two preferred proportions of the prescription range, and uses the optimal process parameters of the preparation method of the present invention to produce the granules. The production of each group is as follows:

[0045] 1 Bounding minimum of square range

[0046] (1) According to the Chinese medicine prescription of the present invention, take 800g of Guizhi, 800g of Scrophulariae, 1000g of Fangji, 1000g of Danshen, 700g of Baiwei, 700g of Guanzhong, 1000g of Angelica, 800g of Campanulaceae, 1100g of Sangjisheng, 700g of Rhizoma Cyperi, and 700g of Danpi , Atractylodes macrocephala 700g, Achyranthes bidentata 1000g, notopterygium 700g, duhuo 60...

Embodiment 2

[0076] Animal toxicity experiment of Chinese medicine preparation of the present invention

[0077] 1 Experimental drug: Chinese medicine granules prepared in Example 1 of the present invention were added with purified water to prepare a thin paste.

[0078] Animals used in the test: normal grade NIH mice, weighing 21g±2g, half male and half female, all female mice were sterile; SD rats, initial weight 231±11g, half male and half female, all female rats were sterile. Experimental animals were purchased from Shanghai Cancer Institute.

[0079] 2 Acute toxicity test

[0080]Application of mice to carry out acute toxicity test shows: mice gavage traditional Chinese medicine granules of the present invention, under the dosage of 636.5g crude drug / kg, after administration, the mice appear slight activity reduction, return to normal in about 1.5 hours, continuous observation after administration After 7 days, none of the mice died, and the general condition, diet, water intake, ur...

Embodiment 3

[0085] Pharmacodynamic experiment

[0086] 1 Effect on the itch threshold of histamine phosphate:

[0087] 30 guinea pigs were randomly divided into 3 groups, which were the blank control group, the drug group of the present invention (the granules produced in Example 1 of the present invention with an optimal ratio of 1, specification: 0.94g crude drug / g granule) and snow asiatica Glycoside cream ointment group. The medicine group of the present invention is intragastrically administered according to the dosage, the asiaticoside group is smeared and administered, and the blank control group is smeared with normal saline. One day before the experiment, the dorsum of the right hind foot of guinea pigs in each group was depilated and the drug was applied once. On the day of the experiment, rough sandpaper was used to scratch the epidermis of the depilated part of the right hind foot for 1 cm 2 20 minutes later, drop 0.01% histamine phosphate 0.05ml / mouse on the scratched and ...

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating scleroderma and a preparation method of the traditional Chinese medicine preparation, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation provided by the invention is mainly prepared from the following traditional Chinese medicinal materials: cassia twig, radix scrophulariae, stephania terandra, salvia miltiorrhiza, blackend swallowwort root, cyrtomium fortunei, angelica sinensis, platycodon grandiflorum, parasitic loranthus, rhizoma cyperi, cortex moutan, white atractylodes rhizome, radix achyranthis bidentatae, notopterygium root, radix angelicae pubescentis, large-leaved gentian, lycopodium clavatum, fructus forsythia, semen brassicae, astragalus membranaceus and liquorice. These traditional Chinese medicinal materials are prepared into a traditional Chinese medicine preparation by the preparation method provided by the invention; when used for treating scleroderma, the traditional Chinese medicine preparation has significant technical advantages of being good in treatment effect, high in recovery rate and easy to cure once through combination of adjustment and treatment; the medicine effect can be ensured by the preparation technology; and the preparation technology has outstanding technical advantages of being simple, feasible and suitable for massive industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating scleroderma and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Scleroderma is a kind of connective tissue disease. It is a collagen disease in which the skin loses its elasticity and hardens. It mostly occurs in middle-aged women. It is similar to "skin numbness" in Chinese medical literature. It is characterized by skin swelling and loss of elasticity at the beginning, then hardening, and finally atrophy. Clinically, it is divided into localized and systemic type 2. The former is divided into three types: flaky, banded and dripping. Although it does not invade any system, it can often cause disability and disfigurement. It is a self-limiting skin disease; the latter has Acral scleroderma and diffuse scleroderma can harden most of the skin of the whole body, accompanied by internal organ lesio...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P17/00
Inventor 王剑
Owner QINGDAO LANSHENGYANG PHARMA & BIOTECH CO LTD
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