Method for preparing depression-relieving and soothing tablets

A satiating and depression-relieving technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and devices that make drugs into special physical or ingestible forms. It can solve the problems of long operation time, large volume of extraction solvent, and unfavorable industrial Problems such as the application of large-scale production, to achieve the effect of shortening the extraction time and improving the extraction efficiency

Inactive Publication Date: 2015-10-07

NANJING HAICHANG CHINESE MEDICINE GRPCO LTD

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AI-Extracted Technical Summary

Problems solved by technology

[0004] The patent number is 201110405141.8 A medicine for treating depression and its preparation method and its application discloses the preparation method. Since the extraction method used in this pate...

Abstract

The invention discloses a method for preparing depression-relieving and soothing tablets. The method includes a first step, preparing raw materials; a second step, extracting alcohol; a third step, collecting extracts; a fourth step, preparing extract powder; a fifth step, granulating the extract powder; a sixth step, compressing tablets. The method has the advantages that anti-depression effects can be realized by water-soluble components and fat-soluble components in herbal medicine in prescription; the ethyl alcohol with certain concentration is used as an extract solvent, accordingly, the water-soluble components and the fat-soluble components with the anti-depression effects in the prescription can be comprehensively extracted, and the method can be used for producing the depression-relieving and soothing tablets on a large scale during industrial mass production.

Application Domain

Heavy metal active ingredientsNervous disorder +5

Technology Topic

Autonomic DrugsAqueous solubility +3

Examples

Experimental program(3)

Example Embodiment

[0039] Example 1

[0040] A preparation method of Jieyu Shunxin Tablets includes the following steps:

[0041] Step 1: Preparation of raw materials: 40 parts of Danshen, 8 parts of Bupleurum, 4 parts of Coptis, 12 parts of Turmeric, 8 parts of Polygala, 8 parts of Shichangpu, 12 parts of keel, 12 parts of oysters, 12 parts of Qingzhushi;

[0042] Step 2: Alcohol extraction: mix the raw materials in step one and add 80% ethanol solution, extract 3 times, each time the ethanol extraction time is 1.5h, the extraction temperature is 75℃, after the extraction is completed The extract is filtered through a 200-mesh sieve, and the filter residue is discarded;

[0043] Step 3: Collecting the paste: Concentrate the filtrate obtained in Step 2 under reduced pressure to an extract with a relative density of 1.25, and the conditions for concentration under reduced pressure are: the vacuum degree is -0.08MPa, the vapor pressure is not greater than 0.04MPa, and the temperature is 70°C;

[0044] Step 4: Prepare extract powder: use spray-dried extract, sterilize after drying, and pass through a sieve above 80 mesh to obtain dry extract powder; the machine model used for spray drying is G-5 high-speed centrifugal spray dryer, spray The relative density is 1.25, the feed rate is 30ml/min, the inlet air temperature is 170°C, and the outlet air temperature is 90°C;

[0045] Step 5: Granulation: Add microcrystalline cellulose and 5‰ sodium carboxymethyl starch to the dry extract powder. The microcrystalline cellulose is added at the ratio of 1.25Kg microcrystalline cellulose per 3Kg dry extract powder. After the mixture is added to the mixer for uniform mixing, 95% ethanol is added to the mixture as a wetting agent to make a soft material, and the soft material is put into granular granules, and the granules are dried; the moisture of the granules is controlled at 8 %. After the granules are dried, they are added to the vortex vibrating sieve and passed through a 16-mesh sieve. Those that fail to pass the sieve are returned to the granular machine;

[0046] Step 6: Compression: The granules obtained in step 5 are compressed into plain tablets; the compression specification is that the weight difference of each tablet is controlled within + 5%, tablet hardness is 60N, tablet press speed is 40 rpm, tablet press pressure is 60KN.

Example Embodiment

[0047] Example 2

[0048] A preparation method of Jieyu Shunxin Tablets includes the following steps:

[0049] Step 1: Preparation of raw materials: 20 parts of Danshen, 4 parts of Bupleurum, 2 parts of Coptis, 8 parts of Turmeric, 4 parts of Polygala, 4 parts of Shichangpu, 8 parts of keel, 8 parts of oysters, 8 parts of Qingzhushi;

[0050] Step 2: Alcohol extraction: mix the raw materials in step one and add 60% ethanol solution, extract 3 times, each time the ethanol extraction time is 1h, the extraction temperature is 65℃, after the extraction is completed, it will be extracted Filter the liquid through a 200-mesh sieve and discard the filter residue;

[0051] Step 3: Collecting paste: Concentrate the filtrate obtained in Step 2 under reduced pressure to an extract with a relative density of 1.2. The conditions for vacuum concentration are: vacuum degree is -0.06MPa, vapor pressure is not greater than 0.04MPa, and temperature is 70°C;

[0052] Step 4: Prepare extract powder: use spray-dried extract, sterilize after drying, and pass through a sieve above 80 mesh to obtain dry extract powder; the machine model used for spray drying is G-5 high-speed centrifugal spray dryer, spray The relative density is 1.2, the feed rate is 25ml/min, the inlet air temperature is 160°C, and the outlet air temperature is 80°C;

[0053] Step 5: Granulation: Add microcrystalline cellulose and 5‰ sodium carboxymethyl starch to the dry extract powder. The microcrystalline cellulose is added at the ratio of 1.25Kg microcrystalline cellulose per 3Kg dry extract powder. After the mixture is added to the mixer for uniform mixing, 95% ethanol is added to the mixture as a wetting agent to make soft materials, and the soft materials are put into granular granules, and the granules are dried; the moisture of the granules is controlled at 4 %. After the granules are dried, they are added to the vortex vibrating sieve and passed through a 16-mesh sieve. Those that fail to pass the sieve are returned to the granular machine;

[0054] Step 6: Compression: The granules obtained in step 5 are compressed into plain tablets; the compression specification is that the weight difference of each tablet is controlled within + 5%, the tablet hardness is 40N, the tablet press speed is 30 rpm, and the tablet press pressure is set to 50KN.

Example Embodiment

[0055] Example 3

[0056] A preparation method of Jieyu Shunxin Tablets includes the following steps:

[0057] Step 1: Preparation of raw materials: 30 parts of Danshen, 6 parts of Bupleurum, 3 parts of Coptis, 10 parts of Turmeric, 6 parts of Polygala, 6 parts of Shichangpu, 10 parts of keel, 10 parts of oyster, 10 parts of Qingzhushi;

[0058] Step 2: Alcohol extraction: mix the raw materials in step one and add 70% ethanol solution, extract 3 times, each time the ethanol extraction time is 1.25h, the extraction temperature is 70℃, after the extraction is completed The extract is filtered through a 200-mesh sieve, and the filter residue is discarded;

[0059] Step 3: Collecting the paste: Concentrate the filtrate obtained in Step 2 under reduced pressure to an extract with a relative density of 1.23. The conditions for vacuum concentration are: vacuum degree -0.07MPa, vapor pressure not greater than 0.04MPa, and temperature 70°C;

[0060] Step 4: Prepare extract powder: use spray-dried extract, sterilize after drying, and pass through a sieve above 80 mesh to obtain dry extract powder; the machine model used for spray drying is G-5 high-speed centrifugal spray dryer, spray The relative density is 1.23, the feed rate is 27ml/min, the inlet air temperature is 165°C, and the outlet air temperature is 85°C;

[0061] Step 5: Granulation: Add microcrystalline cellulose and 5‰ sodium carboxymethyl starch to the dry extract powder. The microcrystalline cellulose is added at the ratio of 1.25Kg microcrystalline cellulose per 3Kg dry extract powder. After the mixture is added to the mixer for uniform mixing, 95% ethanol is added to the mixture as a wetting agent to make a soft material, and the soft material is put into the granulated granules, and the granules are dried; the moisture of the granules is controlled at 6 %. After the granules are dried, they are added to the vortex vibrating sieve and passed through a 16-mesh sieve. Those that fail to pass the sieve are returned to the granular machine;

[0062] Step 6: Compression: The granules obtained in step 5 are compressed into plain tablets; the compression specification is that the weight difference of each tablet is controlled within + 5%, the tablet hardness is 50N, the tablet press speed is 35 rpm, and the tablet press pressure is set to 55KN.

PUM

Property	Measurement	Unit
Hardness	60.0
Hardness	40.0
Hardness	50.0

Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

Reduce extraction time
Improve extraction efficiency

Method for preparing depression-relieving and soothing tablets

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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