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A kind of dracaena leaf extract and its preparation method, its pharmaceutical composition, preparation and application

A technology of extract and dragon's blood, applied in the field of medicine, can solve the problems of leaf extract and its preparation method and application blank, no literature reports, few research reports on dracaena leaves, etc.

Active Publication Date: 2018-03-13
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many domestic and foreign research reports on the lipid-containing wood or dracaena of Dracaena dracaena, but there are fewer research reports on the leaves of Dracaena dracaena, especially in the leaf extract of dracaena dracaena and its preparation method. and use is still blank, no literature reports

Method used

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  • A kind of dracaena leaf extract and its preparation method, its pharmaceutical composition, preparation and application
  • A kind of dracaena leaf extract and its preparation method, its pharmaceutical composition, preparation and application
  • A kind of dracaena leaf extract and its preparation method, its pharmaceutical composition, preparation and application

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preparation example Construction

[0027] The preparation method of dracaena leaf extract of the present invention is characterized in that comprising the following steps:

[0028] A. Crush and sieve the leaves of Dracaena dracaena as raw material, add disodium hydrogen phosphate aqueous solution with a weight ratio of 10-15 times, soak at 10-30°C for 30-120min, ultrasonically extract at 20-30°C for 4-5h, and filter to obtain the extract;

[0029] B. Add hydrochloric acid dropwise to the extract, stir to neutralize and adjust the pH value to 3~5, let it settle at 10~30°C for 8~48h, vacuum filter, wash the filtrate until the pH of the filtered filtrate is 6.5~7.5 , drained;

[0030] C. Add ethanol solution with a weight ratio of 30 to 40 times to the filtrate after drying in step B, extract 2 to 4 times at 60 to 70°C, combine the extracts, and add 0.1 to 0.5% by weight of the extracts for needle use Activated carbon, heated to boiling, then cooled to 30-40°C, filtered with a 0.45 μm microporous membrane to obta...

Embodiment 1

[0042] Example 1 Preparation of Dracaena Leaf Extract 1

[0043] Source and harvesting time of medicinal materials: The leaves of Dracaena used in this experiment are the dried leaves of Dracaena cambodiana Pierre ex Gagnep. The place of origin is Menglian, Yunnan. Picked in August 2014, dried naturally in the sun.

[0044] Preparation:

[0045] After the dried leaves of Dracaena dracaena are selected, crush them with a pulverizer, pass through a 50-mesh sieve, weigh 10 kg of the above-mentioned leaf coarse powder, add 100 kg of 20% disodium hydrogen phosphate aqueous solution, let stand at room temperature and infiltrate for more than 30 minutes. Continuous ultrasonic extraction at 25°C for 5h.

[0046] The above extract was filtered with a polypropylene monofilament filter cloth of model 2815. After the filtrate was collected, 10% hydrochloric acid was added dropwise to stir and neutralize and adjust the pH to 3. It was left to settle at room temperature for more than 8 ho...

Embodiment 2

[0049] Example 2 Preparation of Dracaena Leaf Extract 2

[0050] Source and harvesting time of medicinal materials: The leaves of Dracaena cochinchinensis (Lour.) S. C. Chen used in this experiment are the dried leaves of Dracaenacochinchinensis (Lour.) S. C. Chen, and the place of origin is Pu'er, Yunnan. Picked in July 2014, dried naturally in the sun.

[0051] Preparation:

[0052] After the dried leaves of dracaena are selected, they are pulverized with a pulverizer and passed through a 50-mesh sieve. Weigh 30 kg of the above leaf powder, add 450 kg of 20% disodium hydrogen phosphate aqueous solution, let stand at room temperature and infiltrate for more than 30 minutes, and continuously ultrasonically extract for 4 hours at 25-30°C.

[0053] The above extract was filtered with a polypropylene monofilament filter cloth of model 2815. After the filtrate was collected, 10% hydrochloric acid was added dropwise to stir and neutralize and adjust the pH to 5. It was left to se...

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Abstract

The invention discloses a dracaena leaf extract, a preparation method thereof, a pharmaceutical composition, preparation and application thereof. The dracaena leaf extract is prepared from the dried leaves of Dracaena cambodiana Pierreex Gagnep. or Dracaena cochinchinensis (Lour.) S.C. The total flavonoid content of the dracaena leaf extract is ≥1.0%, and no tannin, resin and oxalate can be detected. The dracaena leaf extract prepared by the invention has remarkable effects of preventing and treating osteoporosis and lowering blood sugar, and has broad clinical application prospects. The preparation method of the dracaena leaf extract provided by the invention has the advantages of easy-to-obtain raw materials, simple operation, economy and environmental protection, stable and controllable product quality, and is suitable for industrial scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a dragon's blood leaf extract, a preparation method thereof, a pharmaceutical composition, preparation and application thereof. Background technique [0002] Dracaena, recorded in volume 14 of "Flora of China", there are about 40 species in the world, mainly distributed in tropical and subtropical regions of Asia and Africa. There are 5 species of Dracaena in my country, mainly distributed in Yunnan, Guangxi, Hainan and Taiwan, respectively: D. cambodiana Pierre ex Gagnep, D. cochinchinensis (Lour.) S. C. Chen, D. angustifolia Roxb., D. gracilis Wall. Ex Baker and D. terniflora Roxb. [0003] Among them, after the trunk of the dracaena is damaged and injured, it will secrete a red blood-like resin when it is invaded and infected by specific fungi such as Fusarium graminearum and other pathogenic bacteria. The trunk wood containing the above resins is extracted with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61P19/10A61P3/10
Inventor 周荣光杨兆祥赵加强
Owner KPC PHARM INC
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