Method for preparing blonanserin micron drug through solvent method
A technology for blonanserin and drugs, applied in the field of chemical drug preparation, can solve the problems of easy agglomeration, uneven micron particles, irregular morphology, etc. Effect
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Embodiment 1
[0019] Add 100ml of 1% polyethylene glycol water stabilizer to a 250ml Erlenmeyer flask, and place it in an ice-water bath at 0-4°C. Weigh 0.285 g (0.78 mmol) of blonanserin, dissolve it in 26 ml of ethanol, prepare a blonanserin ethanol solution with a concentration of 0.03 mol / l, and add it into a 50 ml constant pressure funnel. Place the constant pressure funnel on the Erlenmeyer flask filled with polyethylene glycol aqueous solution, turn on the ultrasonic cleaner, and slowly add the blonanserin ethanol solution dropwise (1ml / min) to the polyethylene glycol solution under ultrasonic conditions of 40KHZ frequency. In the ethylene glycol aqueous solution, the system became cloudy, and continued to sonicate for 30 minutes after the dropwise addition was completed. After the resulting mixed solution was left to stand for 1 h, it was subjected to high-speed centrifugation until it was completely separated, and the supernatant liquid was decanted. The obtained sample was washe...
Embodiment 2
[0025] Add 100ml of 1% polyethylene glycol water stabilizer to a 250ml Erlenmeyer flask, and place it in an ice-water bath at 0-4°C. Weigh 0.184 g (0.50 mmol) of blonanserin, dissolve it in 25 ml of ethanol, prepare a blonanserin ethanol solution with a concentration of 0.02 mol / l, and add it to a 50 ml constant pressure funnel. Place the constant pressure funnel on the Erlenmeyer flask filled with polyethylene glycol aqueous solution, turn on the ultrasonic cleaner, and slowly add the blonanserin ethanol solution dropwise (1ml / min) to the polyethylene glycol solution under the ultrasonic condition of 60KHZ frequency. In the ethylene glycol aqueous solution, the system became cloudy, and continued to sonicate for 30 minutes after the dropwise addition was completed. After the resulting mixed solution was left to stand for 2 h, it was centrifuged at 4000 r / min until it was completely separated, and the supernatant was poured off. The obtained sample was washed with distilled ...
Embodiment 3
[0027] Add 400ml of 1% polyethylene glycol water stabilizer to a 500ml Erlenmeyer flask, and place it in an ice-water bath at 15-20°C. Weigh 1.004 g (2.73 mmol) of blonanserin, dissolve it in 91 ml of ethanol, prepare a blonanserin ethanol solution with a concentration of 0.03 mol / l, and add it to a 100 ml constant pressure funnel. Place the constant pressure funnel on the Erlenmeyer flask filled with polyethylene glycol aqueous solution, turn on the ultrasonic cleaner, and slowly add the blonanserin acetone solution dropwise (1ml / min) to the polyethylene glycol solution under the ultrasonic condition of 40KHZ frequency. In the ethylene glycol aqueous solution, the system became cloudy, and continued to sonicate for 30 minutes after the dropwise addition was completed. After the resulting mixed solution was left to stand for 1 h, it was subjected to high-speed centrifugation until it was completely separated, and the supernatant liquid was decanted. The obtained sample was w...
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