Application of bacteroides intestinalis DSM 17393 strain

A strain and drug technology, applied in the application field of probiotics, can solve the problems of limited effective treatment methods for obesity, large side effects and poor effect of weight loss drugs

Inactive Publication Date: 2015-11-11
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Obesity, as a risk factor for type 2 diabetes, cardiovascular disease and tumors, has become a global social public problem. In the past decade, genome-wide association analysis has discovered more than 100 human obesity susceptibility loci. However, these loci Explains only a limited portion

Method used

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  • Application of bacteroides intestinalis DSM 17393 strain
  • Application of bacteroides intestinalis DSM 17393 strain
  • Application of bacteroides intestinalis DSM 17393 strain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The C57 / BL6 male SPF level mice were randomly divided into control group and bacteria-instilled group, with 7-10 mice in each group. The control group was given aseptic PBS, once a day; 10 8 -10 9 cfu / mouse, for intragastric administration test, once a day. Then give high-fat diet feeding, test 7 weeks. During the period, the body weight growth rate of the mice was recorded, and the fat content was detected after the experiment.

[0023] The body weight and adipose tissue weighing conditions are shown in Table 1 below:

[0024] Table 1

[0025]

[0026]

[0027] As can be seen from the table, after carrying out intragastric administration of BacteroidesintestinalisDSM17393 bacterial strain suspension to mice, body weight and mouse groin subcutaneous fat content and epididymis fat content are significantly increased slowly than mice in the control group, indicating that Bacteroides intestinalisDSM17393 bacterial strain controls body weight and reduces The effe...

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Abstract

The invention belongs to the field of application of probiotics and particularly relates to application of a bacteroides intestinalis DSM 17393 strain in preparation of medicines for treating or preventing obesity. According to the invention, C57/BL6 male SPF-level mice in the same nest are divided into a control group and a strain filling group randomly, a test of filling a bacteroides intestinalis DSM 17393 strain suspension into the stomach is carried out once per day, then the mice are fed with high fat diet, and the test lasts for 7 weeks. The test verifies that the strain is very effective for controlling body weight and body fat, the content of subcutaneous fat of the groin is reduced by 15%, and the content of fat beside the epididymis is reduced by 20.9%. The bacteroides intestinalis DSM 17393 strain can be used for preparing medicines, pharmaceutical compositions, foods and feeds for treating or preventing obesity.

Description

technical field [0001] The invention belongs to the application field of probiotics, in particular to the application of Bacteroides intestinalis DSM17393 bacterial strain in treating or preventing obesity. Background technique [0002] Obesity, as a risk factor for type 2 diabetes, cardiovascular disease and tumors, has become a global social public problem. In the past decade, genome-wide association analysis has discovered more than 100 human obesity susceptibility loci. However, these loci Can only explain a limited number of causes of obesity. Moreover, the current effective treatment methods for obesity are still very limited. Most of the weight-loss drugs approved by the US FDA have been withdrawn from the market due to large side effects or poor effects. It is urgent to develop new weight-loss methods. Another human genome, the gut microbiota genome, is playing an increasingly important role in the development of obesity. Studies have shown that the intestinal flor...

Claims

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Application Information

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IPC IPC(8): A61K35/741A23K1/16A23L1/29A61P3/04
Inventor 宁光洪洁王卫庆刘瑞欣王计秋赵少倩刘文石娟
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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