Doxorubicin and itraconazole co-loaded nanoliposomes and preparation method thereof

Abstract

The invention provides doxorubicin and itraconazole common carrier nano-liposome which is mainly prepared from doxorubicin hydrochloride, itraconazole, phospholipids, other components, an ammonium sulfate solution and water for injection. The average grain diameter is 60-200 nm. The nano-liposome is prepared from, by mass, 1-40 parts of the doxorubicin hydrochloride, 1-20 parts of the itraconazole, 80-140 parts of the phospholipids and 20-100 parts of the other components; the other components are at least one of cholesterol, glycolipid and sitoesterol; the concentration of the ammonium sulfate solution is 100-400 mmol / L, and the water for injection is normal saline or glucose injection with the mass concentration of 5%. Medicine is endowed with a tumor tissue target ability through the lipidosome, tumor angiogenesis and tumor cell proliferation can be effectively restrained, and the toxic and side effects on normal tissue of the human body from the medicine are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicaments, in particular to a liposome co-loaded with doxorubicin and itraconazole and a preparation method thereof. Background technique [0002] At present, significant progress has been made in the prevention and treatment of cancer, but due to the difficulty in early diagnosis of cancer and the lack of effective technical solutions for the treatment of cancer metastasis, curing cancer is still a difficult problem. The crux of the problem is that although anti-cell proliferation drugs can directly kill some tumor cells, the remaining tumor cells can continue to proliferate due to the support of surrounding blood vessels, and even metastasize through blood vessels or lymphatic vessels, resulting in failure of tumor treatment. In response to this problem, the global medical community has adopted "anti-tumor angiogenesis + anti-tumor cell proliferation" treatment schemes in recent years to achieve the g...

AI Technical Summary

Problems solved by technology

It is used for tumor treatment through intravenous administration, and lacks tumor targeting, resulting in poor therapeutic effect on tumors and high toxicity to normal tissues.

2) The above two studies only reported the preliminary results of in vitro cells, and lacked the evaluation results of the treatment effect of tumor-bearing animals in vivo, so it is not enough to comprehensively evaluate the efficacy and side effects of drugs

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