Erythropoietin mimic peptide and preparation method and application thereof

A technology of erythropoietin and mimetic peptides, which is applied in the field of erythropoietin mimetic peptides and its preparation and application, can solve the problems of low EC50 and limitation, and achieve the effect of prolonging the half-life
CN105085653AActive Publication Date: 2015-11-25TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2015-11-25

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Abstract

The invention relates to erythropoietin mimic peptide capable of lastingly promoting erythropoiesis. Amino acid sequence of the erythropoietin mimic peptide is shown as SEQ ID NO:1GGLYAX1HMGPITX2VX3QPLRX4K, wherein X1 is chosen from lysine or arginine, X2 is 3-(1-naphthyl)-L-alanine, X3 is chosen from aspartic acid or glutamine, X4 is sarcosine, and free amino and carboxyl of an amino acid side chain are cyclically condensed between X1 and X3, and N terminal is acetylized. The invention further provides application of the erythropoietin mimic peptide in drug used for treating diseases featured by erythrocyte deficiency or erythrogenin deficiency or erythrocyte group deficiency or defect. The erythropoietin mimic peptide can promote generation of erythrocytes, and half-life period of the drug in vivo is prolonged remarkably.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a structurally similar erythropoietin mimic peptide modified by fatty acid that can bind to and activate erythropoietin receptors or can act as an agonist for erythropoietin The present invention also relates to the application of the structural analogue in the medicine for the treatment of diseases characterized by the lack of erythropoietin or the absence or defect of red blood cell population. Background technique

[0002] Erythropoietin (EPO) is a glycoprotein hormone with a molecular weight of about 34kD. The erythropoietin present in the plasma is composed of 165 amino acids, with a high degree of glycosylation, and the main sugar component is sialic acid. According to different carbohydrate content, naturally occurring erythropoietin is divided into two types, α-type and β-type, among which, α-type contains 34% carbohydrates, and β-type contains 26% carbohydrates. The two types ...

Claims

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