Montmorillonite pellet dry suspension and preparation method thereof

A technology of montmorillonite pellets and dry suspension, which is applied in the field of medicine and can solve problems such as earthy smell, unacceptable patients, and gritty feeling

Active Publication Date: 2015-12-02
HENAN LIFE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the montmorillonite preparations on the market mainly include powders, granules, suspensions and dispersible tablets. These dosage forms have some shortcomings: powders and granules have a gritty and earthy smell when they are mixed with water and taken evenly, which is not easy for patients to accept. Suspensions also have the problem of poor taste; dispersible tablets can be swallowed directly, but the effective dose of this product is relatively large, so the specifications of commercially available dispersible tablets are 1g / tablet, which is difficult to swallow, especially in infants and young children and adolescents when taking
[0004] The document "Azithromycin Taste-Masked Pellets Dry Suspension" reports that Azithromycin is made into pellets, and then adding a suspending agent to make taste-masked pellets dry suspension, but in production practice, due to the prepared pellets and necessary Excipients, such as suspending agents, flavoring agents and essences, have different shapes and particle sizes, so the uniformity of the product cannot be guaranteed in the mixing and filling process
[0005] Through comparison, it is found that the existing montmorillonite preparations generally have a series of problems such as poor taste and inconvenient taking.

Method used

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  • Montmorillonite pellet dry suspension and preparation method thereof
  • Montmorillonite pellet dry suspension and preparation method thereof
  • Montmorillonite pellet dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] The composition of montmorillonite pellets (500g) is:

[0150] name

[0151] The composition of auxiliary material pellets (500g) is:

[0152]

[0153] Montmorillonite pellets: Take the prescribed amount of binder, dissolve it into an appropriate amount of wetting agent (absolute alcohol); add it to the prescribed amount of montmorillonite, and make pellets in the extrusion spheronizer, the particle size is It is 0.1-0.8mm.

[0154] Coating film coating: get the film coating powder of recipe quantity and dissolve in the appropriate wetting agent (85% ethanol), spray evenly on the surface of above-mentioned montmorillonite pellets, and dry with hot air, control weight gain 6%-12 %, the particle size is 0.1-0.8mm.

[0155] Preparation of auxiliary material pellets: take the adhesive of the prescription amount, dissolve it into an appropriate amount of wetting agent (70% ethanol); add it to the flavoring agent and suspending agent of the prescription amount,...

Embodiment 2

[0166] The composition of montmorillonite pellets (500g) is:

[0167]

[0168] The composition of auxiliary material pellets (500g) is:

[0169] name

effect

Proportion

quality

sucrose

flavoring agent

63

235g

Sodium carboxymethyl cellulose

suspending agent

30

240g

pregelatinized starch

Adhesive

7

25g

[0170] Montmorillonite pellets: Take the prescribed amount of binder, dissolve it into an appropriate amount of wetting agent (water); add it to the prescribed amount of montmorillonite, and make pellets in an extrusion spheronizer with a particle size of 0.1 —0.8mm.

[0171] Coating film coating: get the film coating powder of recipe quantity and dissolve in the appropriate wetting agent (85% ethanol), spray evenly on the surface of above-mentioned montmorillonite pellets, and dry with hot air, control weight gain 6%-12 %, the particle size is 0.1-0.8mm.

[0172] Preparation of excipien...

Embodiment 3

[0177] The composition of montmorillonite pellets (500g) is:

[0178]

[0179] The components of auxiliary material pellets (500g) are:

[0180] name

effect

Proportion

quality

sucrose

flavoring agent

56

280g

xanthan gum

suspending agent

37

185g

pregelatinized starch

Adhesive

7

35g

[0181] Montmorillonite pellets: Take the prescribed amount of binder, dissolve it into an appropriate amount of wetting agent (absolute alcohol); add it to the prescribed amount of montmorillonite, and make pellets in the extrusion spheronizer, the particle size is It is 0.1-0.8mm.

[0182] Coating film coating: get the film coating powder of recipe quantity and dissolve in the appropriate amount of wetting agent (20% ethanol), spray evenly on the surface of above-mentioned montmorillonite pellets, and dry with hot air, control weight gain 6%-12 %, the particle size is 0.1-0.8mm.

[0183] Preparation of aux...

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Abstract

The invention belongs to the field of medicines, and relates to a montmorillonite pellet dry suspension having good mouthfeel and being convenient to take, and a preparation method thereof. The montmorillonite film coat pellet dry suspension is composed of montmorillonite pellets and auxiliary material pellets according to a weight ratio of 1:4-5:1.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a dry suspension of montmorillonite pellets and a preparation method thereof. Background technique [0002] Montmorillonite has a layered structure and non-uniform charge distribution, which can fix and inhibit viruses, bacteria and the toxins produced in the digestive tract; it has the ability to cover the mucosa of the digestive tract, and by combining with mucus glycoproteins, Repair and improve the defense function of the mucosal barrier against attacking factors from two aspects of quality and quantity. It is used for adjuvant treatment of acute and chronic diarrhea and related pain symptoms caused by esophagus, stomach and duodenal diseases in adults and children. [0003] At present, the montmorillonite preparations on the market mainly include powders, granules, suspensions and dispersible tablets. These dosage forms have some shortcomings: powders and granules have a gritty and ea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K33/06A61P1/12A61P1/00A61P29/00
CPCA61K9/10A61K9/5026A61K9/5047A61K33/06A61K47/36A61K47/38
Inventor 杨定乾高佩武丰龙龙山魏骆爽
Owner HENAN LIFE PHARMA CO LTD
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