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Method for modifying fluorinated siloxane acrylate material of rigid gas-permeable corneal contact lens

A technology of lens fluorosiloxane acrylate and corneal contact, which is applied in the field of modified rigid gas permeable contact lens materials to achieve the effects of poor comfort, low cost and simple processing technology

Inactive Publication Date: 2015-12-02
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, simple plasma surface treatment can only endow the material with certain surface properties in a short period of time. Due to the timeliness of the plasma treatment effect, the functional groups introduced on the surface of the material will gradually move into the surface and flip over.

Method used

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  • Method for modifying fluorinated siloxane acrylate material of rigid gas-permeable corneal contact lens
  • Method for modifying fluorinated siloxane acrylate material of rigid gas-permeable corneal contact lens
  • Method for modifying fluorinated siloxane acrylate material of rigid gas-permeable corneal contact lens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Ammonia plasma treatment is used as the surface treatment method, and 2-methacryloyloxyethyl phosphorylcholine (MPC) is used as the grafted molecule. The steps are as follows:

[0043] (1) The FSARGPCL contact lens material (BostonXO, Wenzhou Medical College) was cut into thin slices of about 1 mm, polished, cleaned with a digitally controlled ultrasonic cleaner for 15 minutes, rinsed with deionized water, dried at room temperature, and stored for later use.

[0044] (2) Under the ammonia plasma treatment for 120s and the discharge power of 100W, plasma treatment was performed on the FSARGPCL contact lens material.

[0045] (3) Soak the treated material in a 0.02wt% 2-methacryloyloxyethylphosphorylcholine (MPC) aqueous solution for 3 hours, during which time a magnetic stirrer is used to continuously stir.

[0046] (4) Rinse the surface of the contact lens material 3 times with deionized water, dry at room temperature, and store.

[0047] figure 1 SEM photos of the su...

Embodiment 2

[0051] Oxygen plasma treatment is used as the surface treatment method, and 2-methacryloyloxyethyl phosphorylcholine (MPC) is used as the graft molecule, and the steps are as follows:

[0052] (1) The FSARGPCL contact lens material (BostonXO, Wenzhou Medical College) was cut into thin slices of about 1 mm, polished, cleaned with a digitally controlled ultrasonic cleaner for 15 minutes, rinsed with deionized water, dried at room temperature, and stored for later use.

[0053] (2) Under oxygen plasma treatment for 120s and discharge power of 100W, plasma treatment was performed on FSARGPCL contact lens material.

[0054] (3) Soak the treated material in an aqueous solution of 2-methacryloyloxyethylphosphorylcholine (MPC) with a concentration of 0.05wt% for 2 hours, and stir continuously with a magnetic stirrer during this period.

[0055] (4) Rinse the surface of the contact lens material 3 times with deionized water, dry at room temperature, and store.

[0056] figure 2 SEM ...

Embodiment 3

[0060] Ammonia plasma treatment is used as the surface treatment method, polyethylene glycol diacrylate (PEGDA) is used as the graft molecule, and the steps are as follows:

[0061] (1) The FSARGPCL contact lens material (BostonXO, Wenzhou Medical College) was cut into thin slices of about 1 mm, polished, cleaned with a digitally controlled ultrasonic cleaner for 15 minutes, rinsed with deionized water, dried at room temperature, and stored for later use.

[0062] (2) Under the ammonia plasma treatment for 120s and the discharge power of 100W, plasma treatment was performed on the FSARGPCL contact lens material.

[0063] (3) Soak the treated material in a polyethylene glycol diacrylate 10000 (PEGDA10000) aqueous solution with a concentration of 0.01 wt% for 3 hours, and stir continuously with a magnetic stirrer during this period.

[0064] According to the above steps (1)-(3), polyethylene glycol diacrylate 4000 (PEGDA4000) was used as the graft molecule to modify the FSARGPCL...

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Abstract

The invention relates to a method for modifying a material of a rigid gas-permeable corneal contact lens and discloses a method for modifying a fluorinated siloxane acrylate material of a rigid gas-permeable corneal contact lens through plasma treatment and grafting. The method comprises the following steps of carrying out plasma treatment on the fluorinated siloxane acrylate material of the rigid gas-permeable corneal contact lens; and soaking the treated material into a bionic macromolecular water solution to obtain the fluorinated siloxane acrylate material of the rigid gas-permeable corneal contact lens. According to the method, the fluorinated siloxane acrylate material of the rigid gas-permeable corneal contact lens is treated by using a plasma surface treatment method, and then, bionic macromolecules with high hydrophilia, good biocompatibility and protein absorption prevention property are grafted on the surface of the material, so that the hydrophilia of the material is improved, tear is relatively easily spread, the problem of poor comfort when the lens is worn for the first time is solved, the problem that proteins are accumulated because the lens is worn for a long term is not easily caused, the wearing time is prolonged, and the wearing comfort is improved.

Description

technical field [0001] The invention relates to a method for modifying a rigid gas-permeable contact lens material, in particular to a method for modifying a rigid gas-permeable contact lens fluorosiloxane acrylate material through plasma treatment and grafting. This method can improve the hydrophilicity of traditional fluorosilicone acrylate materials, make tears spread out more easily, and solve the problem of poor comfort when wearing them for the first time. It is not easy to cause protein deposition in tears after long-term wearing, and prolongs the wearing time. and improve wearing comfort. The obtained modified material can be applied to the performance improvement and optimization of the rigid gas permeable contact lens. Background technique [0002] Contact lens is a medical optical device mainly used to correct various refractive errors (including myopia, hyperopia, astigmatism and presbyopia), and has been around for more than 100 years. Because it is in direct ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/00C08J7/16G02C7/04
Inventor 任力杨军忠尹诗衡王琳刘卅赵轩王迎军陈浩瞿佳
Owner SOUTH CHINA UNIV OF TECH
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