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Polysaccharides-cellulose haemostatic, isolating, antibacterial and repairing glue solution and preparation method thereof

A technology of cellulose and sodium carboxymethyl cellulose, applied in medical science, bandages, etc., can solve the problems of irritation and limited application, and achieve the effects of promoting production, improving microcirculation, and promoting wound healing

Active Publication Date: 2015-12-09
南京东万生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, quaternary phosphonium salts are irritating when in contact with the skin, thus limiting their application in medical supplies
So far, there have been no relevant reports on the application of quaternary phosphonium salt antibacterial materials to damaged surfaces such as skin and mucous membranes.

Method used

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  • Polysaccharides-cellulose haemostatic, isolating, antibacterial and repairing glue solution and preparation method thereof
  • Polysaccharides-cellulose haemostatic, isolating, antibacterial and repairing glue solution and preparation method thereof
  • Polysaccharides-cellulose haemostatic, isolating, antibacterial and repairing glue solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The content of each component is as follows:

[0054] Sodium carboxymethylcellulose: 3g;

[0055] Methyltriphenylphosphonium bromide: 8g

[0056] Sodium chloride: 8g;

[0057] Water for injection: 1000ml.

[0058] Preparation:

[0059] A. Weigh 3g of sodium carboxymethylcellulose and slowly dissolve it in 1000ml of water for injection, stir for a period of time and let it stand for a while to fully soak and swell until it is completely dissolved. Add 8g of methyltriphenylphosphonium bromide to the above In the solution, turn on the heating program and slowly raise the temperature to 60°C, react at a constant temperature for 2.5 hours, and stir continuously during the process. After the reaction is completed, add 8g of sodium chloride to adjust to an isotonic solution, and lower the temperature of the solution to room temperature and let it stand;

[0060] B. Add activated carbon to the isotonic solution formed in step A, start the heating program to raise the temper...

Embodiment 2

[0064] The content of each component is as follows:

[0065] Sodium carboxymethyl cellulose: 5g;

[0066] Ethyltriphenylphosphonium bromide: 12g;

[0067] Sodium chloride: 9g;

[0068] Water for injection: 1000ml.

[0069] A. Weigh 5g of sodium carboxymethylcellulose and slowly dissolve in 1000ml of water for injection, stir for a period of time and let it stand for a while to fully soak and swell until it is completely dissolved. Add 12g of ethyltriphenylphosphonium bromide to the above In the solution, turn on the heating program and slowly raise the temperature to 65°C, react at a constant temperature for 3 hours, and stir continuously during the process. After the reaction is completed, add 9g of sodium chloride to adjust to an isotonic solution, and lower the temperature of the solution to room temperature and let it stand;

[0070] B. Add activated carbon to the isotonic solution formed in step A, start the heating program to raise the temperature to 75°C, start the c...

Embodiment 3

[0074] The content of each component is as follows:

[0075] Sodium carboxymethylcellulose: 9g;

[0076] Dodecyltriphenylphosphonium bromide: 15g;

[0077] Sodium chloride: 10g;

[0078] Water for injection: 1000ml.

[0079] A. Weigh 9g of sodium carboxymethylcellulose and slowly dissolve it in 1000ml of water for injection. After stirring for a period of time, let it stand for a while to fully soak and swell until it is completely dissolved. Add 15g of dodecyltriphenylphosphonium bromide Into the above solution, turn on the heating program and slowly raise the temperature to 70°C, react at a constant temperature for 2 hours, and stir continuously during the process. After the reaction is completed, add 10g of sodium chloride to adjust to an isotonic solution, and lower the temperature of the solution to room temperature and let it stand;

[0080] B. Add activated carbon to the isotonic solution formed in step A, start the heating program to raise the temperature to 80°C, s...

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Abstract

The invention discloses a polysaccharides-cellulose haemostatic, isolating, antibacterial and repairing glue solution and a preparation method thereof, wherein the glue solution is prepared from sodium carboxymethyl cellulose, a quaternary phosphonium salt antibacterial agent, sodium chloride and injection water by the following steps: dissolving the sodium carboxymethyl cellulose in the injection water according to proportions, reacting with the quaternary phosphonium salt antibacterial agent in a covalent mode, regulating isosmotic pressure by virtue of the sodium chloride, removing pyrogen, regulating pH, filling, sterilizing and the like. The prepared glue solution not only can take a rapid haemostatic effect on wound surfaces, take effects of isolating and lubricating tissue wounds, mucosa and human skin, promote repair and prevent the occurrence of a cohesion phenomenon which can be caused after operations on human tissues or organs, but also can guarantee an excellent haemostatic performance and rapid haemostasis speed; meanwhile, the glue solution can be used for skilling most bacteria and fungi growing from the wound surfaces; and the glue solution has broad-spectrum bacteriostatic and antibacterial functions as well as a long-acting antibacterial effect, and the glue solution is capable of reducing the occurrence of operation infection and postoperative complication, promoting the healing of wounds and improving the microcirculation of wound tissues.

Description

technical field [0001] The invention relates to a medical dressing in surgical operations, in particular to an antibacterial, hemostatic and anti-adhesion repair glue and a preparation method thereof during surgical operations. Background technique [0002] Surgical operations will bring a certain degree of trauma to tissues and organs. How to effectively control the blood seepage of capillaries and venules in the body cavity and the exudation of tissue wounds to avoid the occurrence of adhesions, and how to control the infection of wounded tissues. growing attention. [0003] Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs. The formation of adhesions is universal, and it is reported that 65%-95% of abdominal and pelvic surgeries can lead to different degrees of adhesions. It increases the difficulty of reoperation and the potential for further complications. The purpose of preventing adhesions is to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
Inventor 石星明吴飞
Owner 南京东万生物技术有限公司