Inclined plate type mechanical pain-sensitivity determining device

A measuring device and sloping plate technology, applied in the field of medical devices, can solve the problems of high price, poor availability, and fragile probes, and achieve the effects of reducing experimental costs, good availability, and simple operation.

Inactive Publication Date: 2015-12-23
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although its measurement sensitivity is high, there are serious defects: 1. The price is high and the availability is poor; 2. The user is prone to cervical spine strain: because the observer needs to constantly align the soles of the feet at the bottom of the grid, turning the head and tilting up for a long time It will cause cervical spine strain; 3. The probe is fr

Method used

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  • Inclined plate type mechanical pain-sensitivity determining device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Angle α parameter usage mode (taking rats as an example)

[0031] (1) When using this device to measure pain sensitivity, the horizontal plate 4 of the device is placed flat on the desktop, and the barbed wire 6 is set with a maximum angle as the initial angle (taking 80° as an example), and the rat is placed on the barbed wire 6, and the rat can Hold on to the barbed wire 6 tightly so that it does not slip;

[0032] (2) When the rat is not moving, the magnet 5 is adsorbed on the sole of the measured foot (taking the sole of the left rear foot as an example), so that the probe 7 on the magnet 5 is vertically aligned with the sole of the foot and touches it. If there is no pain, the movement will not occur, that is, the angle of the inclined board 2 can be gradually lowered, so that the stimulation intensity of the probe 7 can be slowly increased; once the rat’s foot is lifted, it means pain, and the inclined board 2 is fixed. At this time, the inclined board 2 correspon...

Embodiment 2

[0034] Stimulation intensity F use mode (take rats as an example)

[0035] (1) The rat to be tested needs to be weighed before using the device for measurement, and the mass is m;

[0036] (2) During the measurement, the horizontal plate 4 of the device is placed flat on the desktop, and the barbed wire 6 is set with a maximum angle as the initial angle (taking 80° as an example), and the rat is placed on the barbed wire 6, and the rat can hold the barbed wire tightly. 6 does not slip;

[0037] (3) When the rat is not moving, the magnet 5 is adsorbed on the sole of the measured foot (taking the sole of the left rear foot as an example). Pain will not cause movement, and then gradually lower the angle α of the slant plate 2. As the angle α decreases, cosα will increase, so the stimulation force F=0.25mgcosα of the probe 7 on the soles of the feet will gradually increase; Once the rat lifts its foot, it means pain, fix the inclined board 2, and record the angle α on the vertic...

Embodiment 3

[0040] Simultaneously measure the use mode of more than one set of data (take the measurement of 2 hind feet as an example)

[0041] (1) When using this device to measure pain sensitivity, the horizontal plate 4 of the device is placed flat on the desktop, and the barbed wire 6 is set with a maximum angle as the initial angle (taking 80° as an example), and the rat is placed on the barbed wire 6, and the rat can Hold on to the barbed wire 6 tightly so that it does not slip;

[0042] (2) When the rat does not move, the barbed wire 6 on its measured rear sole (the same side and the opposite side) each absorbs a magnet 5, so that the probe 7 on the magnet 5 is vertically aligned with the sole of the foot and contacts. Rats will not move if there is no pain. Gradually lower the angle α of the slant plate 2. As the angle α decreases, cos α will increase, so the stimulation force F=0.25mg cos α of the probe 7 on the soles will gradually increase. Increase; once the rat lifts the fo...

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PUM

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Abstract

The invention relates to an inclined plate type mechanical pain-sensitivity determining device which adopts the structure that the bottom side of a vertical plate is vertical to a horizontal plate; the horizontal plate and an inclined plate positioned above the horizontal plate are rotatably connected through a shaft lever; a wire mesh is arranged in the middle of the inclined plate; a magnet is positioned below the wire mesh, a probe is arranged on the magnet and extends out of the wire mesh; angle measuring scales are radially marked on the vertical plate from the left bottom corner to the right top corner. According to the invention, the defects in the prior art that the price is expensive, users are easy to suffer from cervical vertebra strain, the probe is easy to damage, and the pain-sensitivity threshold value of the bottom of only one paw can be determined once are overcome; the determining device has the advantages that the manufacture is simple; angle is used for grading pain degrees, can be directly used as a comparison parameter, and can be converted into force F for comparison according to the formula: F=0.25mgcos alpha, so that the determination accuracy is good; through the measurement of the weight of rats, the paw withdrawal mechanical threshold (the probe irritation force F) of rats can be accurately calculated; therefore, the determining device is applicable to the determination of mechanical pain threshold values of big and small animals.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a slant plate mechanical pain sensitivity measuring device. Background technique [0002] Pain is divided into acute pain and chronic pain. Acute pain is one of the body's protective reflexes, but chronic pain is often a morbid manifestation. Chronic pain often manifests as hyperalgesia and paresthesia at the injured site and adjacent tissues. Chronic pain has the characteristics of complex pathogenesis and mechanism, and is difficult to relieve. Basic research on its mechanism and treatment strategies has always been a research hotspot. [0003] Experimental chronic pain research is inseparable from the measurement of pain behavior. Since pain is a subjective feeling and animals cannot express pain perception, it often involves the measurement of mechanical hyperalgesia and thermal hyperalgesia. The mechanical hyperalgesia measurement is most commonly used. [0004] Before the p...

Claims

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Application Information

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IPC IPC(8): A61B5/00
Inventor 荣辉马正良顾小萍陆翠娥
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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