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Application of agaro-oligosaccharide in preparation of lipid-lowering medicine

A technology of agar oligosaccharide and hypolipidemic drug, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc. Foreground effect

Active Publication Date: 2015-12-23
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the research on agaro-oligosaccharide (AOS) focuses on the structure, preparation process, antioxidant activity and promotion of probiotic growth, but there is no relevant report on the effect of agaro-oligosaccharide on blood lipids and blood sugar.

Method used

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  • Application of agaro-oligosaccharide in preparation of lipid-lowering medicine
  • Application of agaro-oligosaccharide in preparation of lipid-lowering medicine
  • Application of agaro-oligosaccharide in preparation of lipid-lowering medicine

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Embodiment 1

[0015] Preparation and molecular weight determination of embodiment 1 agar oligosaccharide

[0016] (1) Preparation of agar oligosaccharides

[0017] Add 10 g of agar gel into 10 L of distilled water (10 mg / ml) and heat to dissolve, then add 1 mol / L HCl aqueous solution until the final concentration of HCl is 0.1 mol / L, heat and react in a water bath at 60 ° C for 1 hour, after the reaction is completed, add 1 mol / LNaOH aqueous solution to neutralize the pH value of the reaction solution to 7, and then use a nanofiltration membrane with a molecular weight cut-off of 200 to 500 to remove salt, then concentrate and evaporate the retentate under reduced pressure at 50°C to obtain 8 g of agar oligosaccharides, which are recorded as agar The structure of oligosaccharide AO is shown in formula (I).

[0018]

[0019] (2) Determination of molecular weight of agar oligosaccharide AO

[0020] Take agar oligosaccharide AO with 0.1mol / LNa 2 SO 4 Prepare 5mg / ml solution in aqueous ...

Embodiment 2

[0021] Example 2 Application of agar oligosaccharide AO in reducing blood fat and fat

[0022] (1) Therapeutic fatty liver model animal experiments

[0023] ①Experimental animals and grouping: Healthy 20±2g ICR male mice were selected and purchased from Shanghai Slack Animal Center. The mice were randomly divided into three groups, six in each group; the first group was the normal group (CT), the second group was the model group (HF), and the third group was the experimental group (HFA).

[0024] ②Experimental method: Take 30 ICR male mice of 20±2g, 20 of them were fed with high-fat and high-sugar diet, and the rest were fed with normal diet, free to eat; 6 weeks later, blood was taken from the eyelids, blood lipid was measured, and 12 of them were selected for total blood cholesterol > 3.5mmol / L is a fatty liver model mouse, which was randomly divided into HF and HFA; after successful modeling, HF and HFA continued to be fed with high-fat and high-sugar feed, and CT was sti...

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Abstract

The invention discloses application of agaro-oligosaccharide in preparation of a lipid-lowering medicine. The molecular weight of the agaro-oligosaccharide is 5 to 1.5kDa. The structure is -G-[A-G]n-, where n is a positive integer, n is smaller than or equal to 31 and is greater than or equal to 0, G represents D-galactose, and A represents 3,6-inner ether galactose. The invention provides the application of the agaro-oligosaccharide in the preparation of the lipid-lowering medicine, thereby developing a new application field of the agaro-oligosaccharide. According to the agaro-oligosaccharide, blood glucose can be lowered, subcutaneous fat is degraded, and the problem of repairing of fatty liver induced by high fat diet is relieved, so that functions of lowering lipid and losing weight are realized; the agaro-oligosaccharide, serving as the lipid-lowering medicine, does not have any toxic and side effects on a human body, and has a great application prospect.

Description

(1) Technical field [0001] The present invention relates to the application of agar oligosaccharide, in particular to the application of agar oligosaccharide in the preparation of lipid-lowering medicine. (2) Background technology [0002] In recent years, with the improvement of living standards, changes in diet structure, and some people's awareness of self-prevention and health care is not strong, the incidence of metabolic diseases such as hyperlipidemia and fatty liver is on the rise, resulting in obesity and related metabolic diseases. It has become a serious public health problem facing the world, especially in developed and developing countries. Therefore, it is a problem to be solved urgently to find a multifunctional substance such as effectively lowering blood sugar, blood fat, and losing weight. [0003] Agar gum is a polysaccharide derived from marine red algae, which is mainly composed of galactose and 3,6-endogalactose connected alternately by α-(1,3) and β-(...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61K31/729A61P3/06
Inventor 王欣于广利陈秀霞尚庆森尹业师李苗苗
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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