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A kind of anti-tumor solid element microparticle capsule

A technology of capsules and particles, which is applied in the fields of capsule delivery, anti-toxic agents, and medical preparations containing active ingredients, etc. It can solve the problems of slow disintegration release speed, large dosage, and low yield of tablets

Active Publication Date: 2017-08-25
ZHEJIANG WECOME MEDICINE IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guyuan tablets require a large amount of excipients during tablet compression, so the dosage is large and inconvenient to take; tablet compression requires greater pressure, and the disintegration and release speed in the body is slow; The hardness of the tablet is required to be high, if the hardness is not enough, it will be easy to crack when coating, so that the yield of the tablet is low

Method used

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  • A kind of anti-tumor solid element microparticle capsule
  • A kind of anti-tumor solid element microparticle capsule
  • A kind of anti-tumor solid element microparticle capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A solid yuan microparticle capsule, containing 216.7g of astragalus polysaccharide, 55.7g of ginseng reed head and 77.6g of calcium carbonate.

[0024] Its preparation method is:

[0025] 1. Grind ginseng and reed heads in proportion, pass through a 80-mesh sieve, then take 60% of the calcium carbonate in the formula and mix them with ginseng and reed heads, and then grind them together for 3 hours at a grinding temperature of 5°C; pass through a 300-mesh sieve;

[0026] 2. Take astragalus polysaccharide, add the remaining amount of calcium carbonate and mix for 2 hours, the mixing temperature is 15°C; then add the ginseng and reed head mixture in step (1), mix evenly, and granulate with 85% ethanol to form 200 meshes; dried at 60°C, whole grains, packed into capsules.

[0027] The preparation method of astragalus polysaccharide is as follows: take 100g of astragalus, add 10 times the amount of water to decoct three times, the first time for 3 hours, the second and thi...

Embodiment 2

[0029] A solid element microparticle capsule, which contains 200g of astragalus polysaccharide, 50g of ginseng reed head and 60g of calcium carbonate.

[0030] Its preparation method is:

[0031] 1. Grind ginseng and reed heads in proportion, pass through a 50-mesh sieve, then take 50% of the calcium carbonate in the formula and mix them with ginseng and reed heads for 4 hours. The grinding temperature is 8°C; pass through a 400-mesh sieve;

[0032] 2. Take astragalus polysaccharide, add the remaining amount of calcium carbonate and mix for 2.5 hours. The temperature of mixing is 12°C; 240 mesh; dried at 55°C, whole grains, packed in capsules.

[0033] The preparation method of astragalus polysaccharide is as follows: take 100g of astragalus, add 10 times the amount of water to decoct three times, the first time for 3 hours, the second and third times for 2 hours each, combine the decoction, filter, and the filtrate is at 60 ~ 70 ℃, - Concentrate under reduced pressure to a ...

Embodiment 3

[0035] The solid yuan microparticle capsule contains 220g of astragalus polysaccharide, 60g of ginseng reed head and 80g of calcium carbonate.

[0036] Its preparation method is:

[0037] 1. Grind ginseng and reed heads in proportion, pass through a 60-mesh sieve, then take 70% of the calcium carbonate in the formula and mix them with ginseng and reed heads for 4 hours. The grinding temperature is 10°C and pass through a 325-mesh sieve;

[0038] 2. Take astragalus polysaccharide, add the remaining amount of calcium carbonate and mix for 1 hour, the mixing temperature is 15°C; then add the ginseng and reed head mixture in step (1), mix evenly, and granulate with 85% ethanol to form 230 mesh; dried at 55°C, whole grains, packed into capsules.

[0039] The preparation method of astragalus polysaccharide is as follows: take 100g of astragalus, add 10 times the amount of water to decoct three times, the first time for 3 hours, the second and third times for 2 hours each, combine t...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a solid element microparticle capsule and a preparation method thereof. The solid yuan microparticle capsule of the present invention contains 200-220 parts by weight of astragalus polysaccharide, 50-60 parts by weight of ginseng reed head and 60-80 parts by weight of calcium carbonate, preferably contains 216.7 parts by weight of astragalus polysaccharide, 55.7 parts by weight of ginseng reed head and carbonate Calcium 77.6 parts by weight. The solid element microparticle capsule of the present invention reduces the amount of auxiliary materials and the dosage; it does not need to be pressurized during the preparation process, so the disintegration and release speed in the body is fast. The invention reduces the hygroscopicity of the capsule content by improving the preparation method, thereby greatly enhancing the stability of the medicine.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an anti-tumor solid element microparticle capsule and a preparation method thereof. Background technique [0002] Guyuan tablet is prepared from ginseng, reed head and astragalus polysaccharide, which has the effect of nourishing qi and consolidating the root. It is used as an adjuvant treatment for mental fatigue and low immune function and hematopoietic function caused by cancer chemotherapy. Astragalus is the dried root of Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao, a leguminous plant. Excavated in spring and autumn, remove root fibers and root heads, and dry in the sun. Astragalus is mainly produced in Shanxi, Heilongjiang, Inner Mongolia and other provinces. Ginseng reed head is the dry rhizome of Araliaceae plant Panax ginseng C.A.Mey. The preparation process of Guyuan tablets is as follows: ginseng and reed head powder are left, and ast...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/258A61K47/02A61P39/00A61P37/04A61P7/00A61K31/715
Inventor 刘忠良列建乐
Owner ZHEJIANG WECOME MEDICINE IND
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