Antibacterial treatment method of silicon surface

A treatment method and silicon surface technology, applied in medical science, prosthesis, surgery, etc., can solve the problem of reducing the biocompatibility of materials, and achieve the effect of excellent antibacterial performance and biocompatibility

Active Publication Date: 2015-12-23
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many ways to construct antibacterial silicon materials, these methods will significantly reduce the biocompatibility of materials while improving the antibacterial properties of materials.

Method used

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  • Antibacterial treatment method of silicon surface
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  • Antibacterial treatment method of silicon surface

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The antibacterial treatment method of the silicon surface of the present embodiment comprises the following steps:

[0033] (1) Treat the surface of Si(100) with hydrofluoric acid with a volume concentration of 5% for 3 minutes; (2) use ethanol as a solvent to dissolve the silane coupling agent with an alkynyl group at a concentration of 10 mM; (3) configure Click reaction solution, which consists of: 1mM anhydrous copper sulfate, 10mM sodium ascorbate, 500μM antibacterial polypeptide KRWWKWWRR; (4) Add the click reaction solution to the silane coupling agent solution to perform a click chemical reaction, wherein the click reaction solution is mixed with silane The volume ratio of the ethanol solution of the coupling agent is 9:1, the total volume of the solution is 1mL, the reaction time is 4 hours, the temperature is 37°C, and the oxygen content in the reaction is 1ppm; (5) The solution after the reaction is spin-dried, And add the mixed solution of water and ethanol ...

Embodiment 2

[0040] The antibacterial treatment method of the silicon surface of the present embodiment comprises the following steps:

[0041] (1) Treat the surface of Si(100) with 10% hydrofluoric acid for 1 minute; (2) Use ethanol as solvent to dissolve the silane coupling agent with alkynyl groups at a concentration of 1 mM; (3) Configure the click reaction solution, It consists of: 0.5mM anhydrous copper sulfate, 5mM sodium ascorbate, 1mM antibacterial polypeptide KRWWKWWRR; (4) Add the click reaction solution to the silane coupling agent solution to perform a click chemical reaction, wherein the click reaction solution and the silane coupling agent The volume ratio of the ethanol solution is 3:1, the total volume of the solution is 1mL, the reaction time is 1 hour, the temperature is 25°C, and the oxygen content in the reaction is 2ppm; (5) spin dry the solution after the reaction, and add water and the mixed solution of ethanol to re-dissolve the product, wherein the volume ratio of...

Embodiment 3

[0046] The antibacterial treatment method of the silicon surface of the present embodiment comprises the following steps:

[0047] (1) Treat the surface of Si(100) with 8% hydrofluoric acid for 2 minutes; (2) Use ethanol as a solvent to dissolve the silane coupling agent with an alkynyl group at a concentration of 5 mM; (3) Configure the click reaction solution, It consists of: 50 μM anhydrous copper sulfate, 0.5 mM sodium ascorbate, 100 μM antibacterial polypeptide KRWWKWWRRC; (4) Add the click reaction solution to the silane coupling agent solution to perform a click chemical reaction, wherein the click reaction solution and the silane coupling agent The volume ratio of the ethanol solution is 10:1, the total volume of the solution is 1mL, the reaction time is 2 hours, the temperature is 30°C, and the oxygen content in the reaction is 1ppm; (5) spin dry the solution after the reaction, and add water and the mixed solution of ethanol to re-dissolve the product, wherein the vo...

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Abstract

The invention discloses an antibacterial treatment method of a silicon surface. The method comprises the following steps: (1) treating a Si (100) surface of a silicon-based material by virtue of hydrofluoric acid; (2) dissolving silane coupler by taking ethanol as solvent, and obtaining silane coupoler solution; (3), adding a click reaction solution containing antibacterial polypeptide into the silane coupler solution in the step (2), and carrying out the click chemical reaction; (4) spinning drying the solution after the reaction of the step (3), adding a mixed solution of water and ethanol, and re-dissolving a product to obtain a solution; (5) dropwise adding the solution obtained in the step (4) onto the Si (100) surface, carrying out the curing treatment to obtain a silicon-based material with the antibacterial surface. By adopting the method, the antibacterial performance of the silicon material is remarkably improved, and a prepared Si (100) substrate has low biological toxicity.

Description

technical field [0001] The invention relates to medical silicon surfaces, in particular to an antibacterial treatment method for silicon surfaces. Background technique [0002] Silicon is an extremely common element that widely exists in rocks, gravel, and dust. In the earth's crust, it is the second most abundant element, constituting 26.4% of the total mass of the earth's crust. In applications, silicon is widely used as biochips, atomic force microscope tips, etc. due to its excellent semiconductor properties and biocompatibility. [0003] However, during the application process, especially in the biological application process, the bacterial infection problem of silicon-based materials is common. This poses a potential hazard for some silicon-based materials that need to be implanted in the human body. Although there are many methods for constructing antibacterial silicon materials, these methods will significantly reduce the biocompatibility of materials while improv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/02A61L27/54A61L27/02
Inventor 任力王琳王迎军陈军建刘卅施雪涛杨军忠
Owner SOUTH CHINA UNIV OF TECH
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