Method for improving sensitivity of surface plasmon resonance sensor

A sensor and sensitivity technology, applied in the field of measurement, can solve problems such as the influence of system sensitivity

Inactive Publication Date: 2015-12-30
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

However, we found in the research that in addition to the film structure of SPR, the spectral

Method used

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  • Method for improving sensitivity of surface plasmon resonance sensor
  • Method for improving sensitivity of surface plasmon resonance sensor
  • Method for improving sensitivity of surface plasmon resonance sensor

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Embodiment 1

[0039] Embodiments of the present invention provide a method for improving the sensitivity of an SPR sensor, comprising the steps of:

[0040] Step (1), providing a light source and a detector, and obtaining a first spectral response curve of the light source and detector, wherein, within the wavelength range of the first spectral response curve, the spectral response characteristic decreases monotonously with increasing wavelength.

[0041] The light source can be, for example, a tungsten-halogen lamp, a xenon lamp, or an LED. In this embodiment, a tungsten-halogen lamp (Daheng Optoelectronics GCI-060101M, 150W) is selected.

[0042] The detector is, for example, a silicon-based CCD, CMOS, or photodiode array. In this embodiment, a silicon-based CCD camera (QimaingQClick1394) is selected.

[0043] The SPR sensor described in this embodiment is a spectral SPR sensor.

[0044] Obtain the overall spectral response curve of the light source and the detector, and select the first s...

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Abstract

The invention relates to a method for improving the sensitivity of a surface plasmon resonance sensor based on a spectral response curve. The method comprises the steps that the first spectral response curve monotonically decreasing within a selected wavelength range is obtained; the incident angle of the SPR sensor is adjusted, so that within a preset refractometry range, the resonant wavelength of the SPR is within the wavelength range of the spectral response curve and is better at the end of the long wave; the position of the resonant wavelength of the SPR is judged directly through original spectral data of a system, and adopted as output data of the sensor, and therefore the sensitivity of the spectral type SPR sensor is improved.

Description

technical field [0001] The invention belongs to the field of measurement technology, in particular to a method for improving the sensitivity of an SPR (surface plasmon resonance) sensor, more specifically, to a method for improving the sensitivity of an SPR (surface plasmon resonance) sensor based on a spectral response curve method. Background technique [0002] The surface plasmon resonance (SPR) sensing method is a highly sensitive and label-free sensing method, which has been widely used in biology, chemistry, environment, clinical and other fields (ChemRev, 2008, 108:462–493 ). [0003] This method uses a special SPR excitation device (such as a layer of metal film coated on the inclined surface of a prism) to detect the relationship between the intensity, phase, wavelength and incident angle of reflected light, and can achieve a better than 10 -5 to 10 -7 (refractive index unit, RIU) resolution detects the change of the refractive index on the surface of the metal f...

Claims

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Application Information

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IPC IPC(8): G01N21/552G01N21/41
Inventor 刘乐陈振翎何永红郭继华
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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