Calcium phosphate bone cement with collapse resistance as well as preparation method and application thereof

A calcium phosphate bone cement, anti-collapse technology, applied in medical science, prosthesis, etc., can solve the problems of delaying CPC curing time, hindering CPC hydration speed, hindering bone cement crystallization, etc., achieving good clinical application effect, good biological Medical performance, the effect of improving the anti-collapse performance

Active Publication Date: 2016-01-13
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because HPMC forms a network structure similar to a film and wraps the cement, it hinders or slows down the hydration rate of CPC and hinders the crystallization of bone cement, so HPMC will reduce the strength of bone cement (JPourchez, APeschard, PGrosseau, et al. .HPMCandHEMCinfluenceoncementhydratio...

Method used

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  • Calcium phosphate bone cement with collapse resistance as well as preparation method and application thereof
  • Calcium phosphate bone cement with collapse resistance as well as preparation method and application thereof
  • Calcium phosphate bone cement with collapse resistance as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Fenugreek gum (the mass is 3.0% of the tetracalcium phosphate-calcium hydrogen phosphate bone cement powder) was evenly mixed with the tetracalcium phosphate-calcium hydrogen phosphate bone cement powder. Then, the deionized aqueous solution was uniformly mixed with the calcium phosphate bone cement containing fenugreek gum prepared in this example at a liquid-solid ratio of 0.5mL / g, and the paste was injected into a mold and placed in simulated body fluid at 37°C . The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing fenugreek gum prepared in this example and the calcium phosphate bone cement without galactomannan vegetable glue is shown in Table 1:

[0027] Table 1

[0028]

[0029] Note: "-" indicates the calcium phosphate bone cement without galactomannan vegetable glue; "+" indicates the calcium phosphate bone cement with galactomannan vegetable glue added, the same as the following table. The ...

Embodiment 2

[0032] The guar gum (the mass is 2.0% of the tetracalcium phosphate-β-tricalcium phosphate-dicalcium phosphate bone cement) was evenly mixed with the tetracalcium phosphate-β-tricalcium phosphate-dicalcium phosphate bone cement. Then uniformly mix the 0.125mol / L sodium dihydrogen phosphate solution with the calcium phosphate bone cement containing guar gum prepared in this example according to the liquid-solid ratio of 0.4mL / g, and mix it into a paste and inject it into the mold after forming. In simulated body fluid at 37°C. The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing guar gum prepared in this example and ordinary calcium phosphate bone cement is shown in Table 2:

[0033] Table 2

[0034]

[0035] Compared with the ordinary calcium phosphate bone cement, the anti-collapse calcium phosphate bone cement containing guar gum prepared in this example has an anti-collapse coefficient of 89±3%, which ...

Embodiment 3

[0037] Tara gum (the mass is 1.0% of α-tricalcium phosphate-calcium hydrogen phosphate-calcium carbonate bone cement) was evenly mixed with α-tricalcium phosphate-calcium hydrogen phosphate-calcium carbonate bone cement. Then uniformly mix the 0.25mol / L sodium hydrogen phosphate buffer solution with the calcium phosphate bone cement containing tara gum prepared in this example according to the liquid-solid ratio of 0.5mL / g, and mix it into a paste and inject it into the mold and place it in the In simulated body fluid at 37°C. The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing tara gum prepared in this example and ordinary calcium phosphate bone cement is shown in Table 3:

[0038] table 3

[0039]

[0040]Compared with ordinary calcium phosphate bone cement, the anti-collapse calcium phosphate bone cement containing tara gum prepared in this example has an anti-collapse coefficient of 84 ± 1%, which is...

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Abstract

The invention discloses calcium phosphate bone cement with collapse resistance. The calcium phosphate bone cement is composed of calcium phosphate bone cement and galactomannan vegetable gelatin, wherein the weight of the galactomannan vegetable gelatin accounts for 0.3-3.0% of that of the calcium phosphate bone cement. The invention further discloses a preparation method and an application of the calcium phosphate bone cement with collapse resistance. According to the invention, the galactomannan vegetable gelatin is successfully applied to the calcium phosphate bone cement for the first time, meanwhile, the requirements of significantly improving the collapse resistance of the calcium phosphate bone cement, keeping the original curing characteristics of the calcium phosphate bone cement, and guaranteeing that hydration products have no large influences on the mechanical properties of the calcium phosphate bone cement are met, and the success rate of the operation is effectively improved. According to the calcium phosphate bone cement, as well as the preparation method and application thereof, the novel medical value of the galactomannan vegetable gelatin is expanded, and the calcium phosphate bone cement has relatively wide application prospects.

Description

technical field [0001] The invention relates to a medical material for repairing bone damage, in particular to an anti-collapse calcium phosphate bone cement and its preparation method and application. Background technique [0002] Calcium phosphate bone cement (CPC) is composed of calcium phosphate powder as the main solid phase component, deionized water or aqueous solution or blood as the liquid phase, and the solid phase powder and liquid phase are mixed to form a paste, which occurs at room temperature or at body temperature. Hydration reaction and self-curing, the main product after curing is hydroxyapatite. Because the chemical composition of CPC is similar to the inorganic components of hard tissues such as human bones and teeth, and has good biocompatibility and osteoconductivity, can be shaped arbitrarily, and can be used as a drug sustained-release carrier, it has become a clinical practice. It is one of the hotspots in research and application in the field of bo...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/20A61L27/50
Inventor 叶建东刘婧群李继彦
Owner SOUTH CHINA UNIV OF TECH
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