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Antineoplastic drugs containing lidocaine

A lidocaine and drug technology, applied in the field of anti-tumor drugs, can solve problems such as difficult treatment work

Active Publication Date: 2018-05-25
SHANXI TUMOUR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there will be cases that are not sensitive to a variety of antitumor drugs in clinical practice, which will cause difficulties in the treatment work.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Effect of lidocaine alone or in combination with mitomycin on inhibition of human bladder cancer cell line BIU-87.

[0015] Taking human bladder cancer cell line BIU-87 as the target cells, the inhibitory effects of lidocaine and mitomycin alone and in combination on the target cells were detected by MTT colorimetry.

[0016] 1 material

[0017] 1.1 Cell line The human bladder cancer cell line BIU-87 was donated by Yang Xiaofeng, director of the Urology Department of the First Affiliated Hospital of Shanxi Medical University.

[0018] 1.2 Lidocaine hydrochloride injection, specification: 10ml:0.2g, batch number: 20141118, valid until October 2017; mitomycin for injection, specification: 2mg, batch number: 130803, valid until July 2016, Zhejiang Hisun Pharmaceutical Co., Ltd. company.

[0019] 1.3 Reagents and consumables RPMI 1640 medium was purchased from Gibco in the United States, fetal bovine serum was purchased from Hangzhou Sijiqing Bioengineering Materials Co....

Embodiment 2

[0035] Effects of lidocaine alone or in combination with pirarubicin on killing BIU-87 cells.

[0036]The human bladder cancer cell line BIU-87 was used as the target cell, and the inhibitory effect of pirarubicin alone and in combination with lidocaine on the target cell was detected by MTT colorimetry.

[0037] 1 material

[0038] 1.1 Cell line The human bladder cancer cell line BIU-87 was donated by Yang Xiaofeng, director of the Urology Department of the First Affiliated Hospital of Shanxi Medical University.

[0039] 1.2 Lidocaine hydrochloride injection, specification: 10ml:0.2g, batch number: 20141118, valid until October 2017; pirarubicin hydrochloride for injection, specification: 10mg, batch number: 1410C15, valid until September 2016, Shenzhen Wanle Pharmaceutical Co., Ltd. company.

[0040] 1.3 Reagents and consumables RPMI 1640 medium was purchased from Gibco in the United States, fetal bovine serum was purchased from Hangzhou Sijiqing Bioengineering Materials ...

Embodiment 3

[0056] Effects of lidocaine alone or combined with Sufuning lotion on killing BIU-87 cells.

[0057] Taking the human bladder cancer cell line BIU-87 as the target cells, the inhibitory effect of Sufuning lotion alone and combined with lidocaine on the target cells was detected by MTT colorimetry.

[0058] 1 material

[0059] 1.1 Cell line The human bladder cancer cell line BIU-87 was donated by Yang Xiaofeng, director of the Urology Department of the First Affiliated Hospital of Shanxi Medical University.

[0060] 1.2 Drug lidocaine hydrochloride injection, specification: 10ml:0.2g, batch number: 20141118, valid until 2017.10; Sufuning Lotion (lyophilized) (SFN), specification: 125mg, batch number: 20140218, valid until 2016.02.17, issued by Provided by the Animal Laboratory of Shanxi Cancer Hospital.

[0061] 1.3 Reagents and consumables RPMI 1640 medium was purchased from Gibco in the United States, fetal bovine serum was purchased from Hangzhou Sijiqing Bioengineering M...

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Abstract

The invention relates to an antitumor drug containing lidocaine, which is prepared by dissolving lidocaine in a medically acceptable solvent, and the concentration of lidocaine is 1.25mg / ml-5mg / ml, or lidocaine The perfusion solution is made by combining with commonly used anti-bladder cancer perfusion drugs. The method of use is to use the above-mentioned medicinal solution immediately after preparation, pour the medicinal solution into the bladder cavity with a catheter, and keep the medicinal solution in the bladder cavity for 60-90 minutes before being discharged by itself. Lidocaine can directly inhibit tumor cells at a certain concentration, and the inhibitory effect is enhanced with the increase of drug concentration. When used in combination with anti-tumor drugs, lidocaine can enhance the anti-tumor effect of anti-tumor drugs, improve the anti-tumor effect of chemotherapy drugs, especially reduce the stimulating and toxic effects of chemotherapy drugs on the body during local drug treatment of tumors , reduce local pain, and improve the effect of tumor treatment.

Description

technical field [0001] The invention relates to an antitumor drug, in particular to an antitumor drug containing lidocaine for treating bladder cancer. Background technique [0002] Bladder cancer is one of the most common malignant tumors of the urinary system, ranking fourth in the United States and eighth in my country. Ninety percent of bladder cancers are transitional cell carcinomas, of which 70% are superficial bladder cancers, that is, tumors confined to the lamina propria of the bladder mucosa. Bladder cancer has a high recurrence rate. About 40%-70% of patients treated with surgery alone will relapse within two years, and the five-year recurrence rate of superficial bladder cancer can reach 90%, and about 10% can progress to invasive bladder cancer. According to the characteristics of easy recurrence of bladder cancer, postoperative intravesical infusion of drugs can achieve the purpose of removing residual tumor, preventing recurrence and delaying progression. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/167A61K45/00A61P35/00
Inventor 杨喜花任连生张蘋
Owner SHANXI TUMOUR INST
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