Composition and application of composition in medicine for resistance of erythrocyte low anemia
A low red blood cell and composition technology, applied in the field of preparation and composition, can solve the problems of insufficient hematopoietic raw materials or utilization barriers
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Embodiment 1
[0032] The preparation of embodiment 1 compound Schiglautone A
[0033] The preparation method of the compound Schiglautone A (I) refers to the method published by Fan-Yu Mengetal.
[0034]
Embodiment 2
[0035] The synthesis of the O-bromoethyl derivative (II) of embodiment 2SchiglautoneA
[0036] Compound I (502 mg, 1.00 mmol) was dissolved in 15 mL of benzene, and tetrabutylammonium bromide (TBAB) (0.08 g), 1,2-dibromoethane (7.520 g, 40.00 mmol) and 6 mL of 50% sodium hydroxide solution. The mixture was stirred at 35 °C for 8 h. After 8 hours, the reaction solution was poured into ice water, extracted twice with dichloromethane immediately, and the organic phase solutions were combined. Then the organic phase solution was washed with water and saturated brine three times successively, then dried with anhydrous sodium sulfate, and finally concentrated under reduced pressure to remove the solvent to obtain a crude product. The crude product was purified by silica gel column chromatography (mobile phase: petroleum ether / acetone=100:1.0, v / v), the brown concentrated elution band was collected and the solvent was evaporated to obtain a brown powder of Compound II (508mg, 71%) ...
Embodiment 3
[0041] The synthesis of the O-(diethylamino) ethyl derivative (III) of embodiment 3 Schiglautone A
[0042] Compound II (358mg, 0.5mmol) was dissolved in 10mL of acetonitrile, anhydrous potassium carbonate (690mg, 5.0mmol), potassium iodide (168mg, 1.0mmol) and diethylamine (2920mg, 40mmol) were added thereto, and the mixture was heated to reflux for 8h . After the reaction, the reaction solution was poured into ice water, extracted twice with an equal amount of dichloromethane, and the organic phases were combined. The combined organic phases were successively washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent to obtain a crude product. The crude product was purified by silica gel column chromatography (mobile phase: petroleum ether / acetone=100:1.0, v / v), the brown concentrated elution band was collected and the solvent was evaporated to obtain a brown powder of compound III (231.2mg, 66% ...
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