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Itopride hydrochloride composition

A technology of itopride hydrochloride and magnesium stearate, applied in the directions of drug combination, drug delivery, organic active ingredients, etc., can solve the problem of large difference in release degree, etc., and achieve the effect of solving large difference in release degree between tablets

Active Publication Date: 2019-07-12
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hydroxypropyl methylcellulose is a commonly used skeleton-type sustained-release material. In the process, there is a problem that the release rate of the same batch of tablets varies greatly

Method used

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  • Itopride hydrochloride composition

Examples

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Effect test

Embodiment 1

[0024] Embodiment 1, itopride hydrochloride 75g, hydroxypropyl methylcellulose K4M25g, hydroxypropylmethylcellulose K10015g, sodium alginate 25g, microcrystalline cellulose 30g, micropowder silica gel 8g, povidone K30 6g, Magnesium stearate 3g. Prepare 1000 tablets according to the preparation method described in the technical solution section.

Embodiment 2

[0025] Example 2, 75g of itopride hydrochloride, 45g of hydroxypropyl methylcellulose K4M, 15g of sodium alginate, 40g of microcrystalline cellulose, 8g of micronized silica gel, 7g of povidone K30, and 3g of magnesium stearate. Prepare 1000 tablets according to the preparation method described in the technical solution section.

Embodiment 3

[0026] Example 3, 75g of itopride hydrochloride, 50g of hydroxypropyl methylcellulose K100, 18g of sodium alginate, 50g of microcrystalline cellulose, 13g of micronized silica gel, 6g of povidone K30, and 4g of magnesium stearate. Prepare 1000 tablets according to the preparation method described in the technical solution section.

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PUM

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Abstract

The invention relates to an itopride hydrochloride sustained-release tablet composition. The technical scheme comprises that the cores of per 1000 tablets of itopride hydrochloride composition comprises 75 g of itopride hydrochloride, 45 g of Hydroxypropyl methyl cellulose, 15 g of sodium alginate, 40 g of microcrystalline cellulose, 8 g of aerosi, 7 g of polyvinylpyrrolidone K30, and 3 g of magnesium stearate. The beneficial effects comprise that the itopride hydrochloride sustained-release tablet according with clinic requirements is obtained through reasonable prescription adjusting, and the problem that the table release degree difference of the itopride hydrochloride sustained-release tablets is large is solved.

Description

technical field [0001] The invention relates to an itopride hydrochloride sustained-release tablet composition. Background technique [0002] Itopride hydrochloride increases the release of acetylcholine through the antagonism of dopamine D2 receptors, and at the same time inhibits the decomposition of released acetylcholine through the inhibition of acetylcholinease, thereby enhancing the motility of the stomach and duodenum. This product has a good gastric motility effect and is suitable for various symptoms caused by functional dyspepsia. It can enhance the contractility of the stomach and duodenum, accelerate gastric emptying, and have the effect of inhibiting vomiting. [0003] Since the commercially available itopride preparation is a regular-release dosage form, 50 mg per tablet, 1 tablet each time, 3 times a day, the patient's compliance is poor. No extended-release itopride tablets are marketed. [0004] Sustained-release preparations refer to preparations that de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/166A61K47/36A61P1/14A61P1/08
Inventor 高然林春付玉麦
Owner DISHA PHARMA GRP
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