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Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof

An antibacterial and anti-inflammatory, pharmaceutical preparation technology, applied in the direction of anti-inflammatory agents, antibacterial drugs, drug combinations, etc., to achieve the effect of inhibiting and killing bacteria, improving immunity, and resisting bacterial infection

Inactive Publication Date: 2016-01-27
严瑾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, graphene is mainly used in the fields of electronics, energy, and materials, and there are no literature reports on the specific application of graphene in natural antibiotics.

Method used

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  • Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof

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preparation example Construction

[0029] In a second aspect, the present invention provides a method for preparing the above-mentioned antibacterial and anti-inflammatory composition, comprising the following steps:

[0030] (1) One or more natural antibiotics are pulverized into coarse powder and mixed uniformly, and the extract is obtained through extraction;

[0031] (2) adding the graphene powder into the extract, ultrasonically vibrating, and drying to obtain the antibacterial and anti-inflammatory composition.

[0032] The extraction described in the above step (1) can adopt traditional extraction methods, such as decoction, solvent extraction, etc., or modern extraction methods, such as ultrasonic extraction, supercritical fluid extraction, etc. In one scheme, the method of decocting is used for extraction, specifically: one or more dried natural antibiotics are crushed into coarse powder and mixed uniformly, decocted with water, filtered, repeated several times, and the filtrates are combined to obtain...

Embodiment 1

[0043] The preparation method of embodiment 1 composition

[0044] (1) Take 100g of dried Houttuynia cordata and crush it into a coarse powder, add appropriate amount of distilled water to decoct, boil it and simmer for 30 minutes, filter, decoct 3 times in total, combine the filtrate, and concentrate to 50mL to obtain the extract.

[0045] (2) Take 1 g of dried graphene powder, add the extract prepared in step (1), ultrasonically oscillate for 1 hour, and the ultrasonic power is 500w, pre-freeze the resulting mixture at -50°C, wait until it is completely frozen, and then freeze it in a vacuum Sublimation drying was carried out under the conditions of temperature 60Pa and temperature 10°C for 12 hours, and finally secondary drying was carried out at 20°C to obtain composition powder.

Embodiment 2

[0046] The preparation method of embodiment 2 compositions

[0047] (1) Take 5kg of dried Houttuynia cordata and crush it into a coarse powder, add appropriate amount of distilled water to decoct, boil it with a slow fire for 30 minutes, filter, decoct 3 times in total, combine the filtrates, and concentrate to 500mL to obtain the extract.

[0048] (2) Take 1 g of dried graphene powder, add the extract prepared in step (1), ultrasonically oscillate for 1 hour, and the ultrasonic power is 500w, pre-freeze the resulting mixture at -50°C, wait until it is completely frozen, and then freeze it in a vacuum Sublimation drying was carried out under the conditions of temperature 60Pa and temperature 10°C for 12 hours, and finally secondary drying was carried out at 20°C to obtain composition powder.

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Abstract

The invention discloses an antibacterial anti-inflammatory composition and a preparation method and a pharmaceutical preparation thereof, belonging to the field of medical preparations. The composition is composed of natural antibiotics and graphene at the first time, wherein the natural antibiotics are selected from one or more of houttuynia cordata, pomegranate bark, common andrographis herb, astragalus, isatis root, white paeony root, honeysuckle flower, radix bupleuri, scutellaria baicalensis, radices trichosanthis, mother chrysanthemum, dandelion, folium isatidis, selfheal, radix sophorae flavescentis, purslane, rheum officinale, moutan bark, sweet wormwood, perilla leaf, liquorice, agastache rugosus, realgar, fructus forsythiae, garlic, polygonum cuspidatum, coptis chinensis, the tuber of stemona or golden cypress. According to the composition, the two components have a synergistic effect, and good antibacterial anti-inflammatory effects are achieved.

Description

technical field [0001] The invention relates to the field of medical preparations, in particular to an antibacterial and anti-inflammatory composition. Background technique [0002] Antibiotics are a class of secondary metabolites produced by microorganisms (including bacteria, fungi, actinomycetes) or higher animals and plants in the course of life, which have anti-pathogen or other activities, and can interfere with the development of other living cells. Chemical substances . Natural antibiotics, such as Houttuynia cordata, purslane, dandelion, etc., are often used in the field of medicine to replace antibiotics in Western medicine, which can play a good antibacterial and anti-inflammatory effect. [0003] Graphene has high specific surface area, outstanding thermal conductivity and mechanical properties, extraordinary electron transfer performance, and certain antibacterial activity. It can theoretically be applied in the fields of electronics, information, energy, physi...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K33/44A61K33/36A61K36/185A61K36/19A61K36/195A61K36/315A61K36/855A61K36/233A61K36/282A61K36/287A61K36/288A61K36/355A61K36/428A61K36/481A61K36/484A61K36/489A61K36/532A61K36/535A61K36/536A61K36/539A61K36/634A61K36/704A61K36/708A61K36/71A61K36/65A61K36/718A61K36/756A61K36/8962A61K36/904A61P31/04A61P29/00
Inventor 严瑾
Owner 严瑾
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