Portable surface plasma resonance biochemical detection device based on intelligent mobile phone as well as portable mobile phone accessories and application thereof

Abstract

The invention discloses a portable surface plasma resonance biochemical detection device based on an intelligent mobile phone as well as portable mobile phone accessories and application thereof. Specifically, a small-sized portable mobile phone sensor is designed and developed by using grating coupling surface plasma resonance optical technology and the biological sensing principle. The mobile phone sensor comprises a flashlight of an intelligent mobile phone, a polarizer, a glass filter only used during optical circuit calibration, a grating coupling metal nanostructure sensing chip, a diffraction light disk and a CCD camera system of the same intelligent mobile phone which are connected in sequence according to the optical circuit. The biosensor has the characteristics of simple equipment structure, convenience in operation, high intelligent degree, low cost and the like; the microminiaturization of the equipment is solved; the domestic individualized diagnosis and treatment are implemented; the detection limit of endotoxin LPS detected by the portable surface plasma resonance biochemical detection device is 32.5ng / ml.

Description

technical field [0001] The invention relates to a portable biochemical detection device. Specifically, using the optical technology of grating-coupled surface plasmon resonance (SPR) and the principle of biosensing, a portable biochemical detection device based on a smartphone is designed and developed, and a portable biochemical detection device based on a smartphone is provided. Mobile phone accessories, so as to realize the detection of biomolecules, belong to the technical field of biochemical sensing detection. Background technique [0002] In recent years, with the promotion of the development achievements of biological science, information science and material science, biosensors have been deeply valued and widely used in chemical technology, environmental monitoring, food engineering, clinical medicine, military and family medicine, etc. However, at present, the application of biosensors still faces difficulties and challenges, mainly including: preparation of biose...

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and provide a portable surface plasmon resonance biochemical detection device based on smart phones, to solve the shortcomings of traditional SPR biosensors such as complex technology, high cost, and huge equipment. At the same time, it also solves the miniaturization of the current SPR sensor detection equipment, and gradually moves towards the personalized diagnosis of the family

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