Unlock instant, AI-driven research and patent intelligence for your innovation.

Systems and methods for using mechanistic network models in systems toxicology

A causal network model, technology of biological systems, applied in the field of systems and methods using mechanistic network models in system toxicology, can solve problems such as hazards

Active Publication Date: 2016-02-03
PHILIP MORRIS PROD SA
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these approaches are still compromised by assumptions, simplifications, and often limited experimental datasets [Lecca, P. and Priami, C. (2012) Biological network inference for drug discovery. Drug discovery today]

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Systems and methods for using mechanistic network models in systems toxicology
  • Systems and methods for using mechanistic network models in systems toxicology
  • Systems and methods for using mechanistic network models in systems toxicology

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0131] Example 1: Xenobiotic Metabolism Networks as Biomarkers for CS Exposure on In Vivo and In Vitro Systems

[0132]Humans and other mammals are equipped with elaborate mechanisms to address carcinogens and other toxic compounds; the defense system includes oxidation reactions by cytochrome P450 enzymes (CYP; phase 1), followed by conjugation reactions by phase 2 enzymes. These enzymes in turn convert lipophilic chemical compounds into hydrophilic water-soluble forms that can be eliminated from the body [Burchell, B. et al. (2005) Substrate Specificity of Human Hepatic Udp-Glucuronosyl transferases. Methods in enzymology. 400, 46-57; Guengerich, F.P. ( 2001) Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol. 14, 611-50; Transformation of polycyclic aromatic hydrocarbons (PAHs), also present in cigarette smoke (CS), can lead to the generation of oncogenic intermediates capable of interacting with genomic DNA [Kim, J.H...

example 2

[0137] Example 2: Mechanistic approach for the quantification of perturbed processes in the lungs of C57 / B16 mice following CS exposure and cessation

[0138] Chronic obstructive pulmonary disease (COPD) is the leading cause of chronic disease and death in the world [Mathers, CD. and Loncar, D. (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine. 3, e442]. C57 / B16 mice exposed to CS provide valuable insight into emphysema initiation and development [Churg, A. Cosio, M. and Wright, J.L. (2008) Mechanisms of cigarette smoke-induced COPD: insights from animal models. American Journal of Physiology-Lung Cellular and Molecular Physiology. 294, L612 -L631], although this mimics only certain aspects of early human COPD characterized by reduced lung function, abnormal inflammatory responses in the airways, small airway remodeling and destruction of alveolar tissue [Pauwels, R.A. and Rabe, K.F. (2004 ) Burden and clinical features of chronic ob...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A set of treatment data corresponding to a response of the biological system to the agent and a set of control data corresponding to a response of the biological system not exposed to the agent are received, and a first computational causal network model and a second computational causal network model that each represents a biological process in the biological system are identified. Based on the set of treatment data and the set of control data, a first score for the first computational causal network model and a second score for the second computational causal network model are computed. A factor is generated based on the first score, the second score, and an intersection between the first computational causal network model and the second computational causal network model, wherein the factor represents the perturbation of the biological system in response to the agent.

Description

[0001] References to related applications [0002] This application claims priority under 35 U.S.C. §119 to U.S. Provisional Patent Application No. 61 / 815,188, filed April 23, 2013, entitled "Systems and Methods for Using Mechanistic Network Models in Systems Toxicology," which is hereby incorporated by reference in its entirety. Background technique [0003] The human body is constantly perturbed by exposure to potentially harmful agents that pose serious health risks in the long run. Exposure to these agents can jeopardize the normal functioning of biological mechanisms within the human body. To understand and quantify the effects of these perturbations on the human body, researchers study the mechanisms by which biological systems respond to exposure to agents. Certain groups make extensive use of in vivo animal testing methods. However, animal testing methods are not always sufficient because of questions about their reliability and relevance. There are many differences...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G06F19/12
CPCG16B5/00Y02A90/10G06F17/10
Inventor F·马丁
Owner PHILIP MORRIS PROD SA