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Medicament for treating functional gastrointestinal disorders

A functional and barrier technology, used in non-central analgesics, antipyretics, anti-inflammatory agents, etc.

Inactive Publication Date: 2016-02-17
WUXI CHENGBO SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic effects of the above-mentioned patents on functional gastrointestinal disorders (especially functional gastroduodenal disorders) need to be further improved

Method used

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  • Medicament for treating functional gastrointestinal disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The rats were allowed to take the enteral nutritional supplement ELENTAL (0.25 g / mL; manufactured by Ajinomoto Co., Inc.) contained in a water bottle freely for 7 days, and then treated with TNBS (2,4,6-trinitrobenzenesulfonic acid )treat. Rats were fasted from the day before the day of TNBS dosing and contained drinking water instead of ELENTAL in the water delivery bottle. On the day of TNBS treatment (rat: 8-week old), 10 mL of physiological saline was rectally injected into the rat under anesthesia with ether to wash intestinal contents. After washing, the rats were allowed to rest for more than 2 hours, and 1 mL of a solution of 5 or 30 mg / head of TNBS in 40% ethanol / physiological saline (vehicle) was administered by rectal injection under anesthesia with pentobarbital. In addition, a silicon plug was inserted into the anus of the rat so that the TNBS solution remained at the injection site, and an elastic bandage (Elastopore) of adhesive fabric was used to fix ar...

preparation Embodiment 1

[0051] Preparation Example 1 (Tablet)

[0052] Tablets were obtained according to the usual manner described in the Japanese Pharmacopoeia using the following ingredients. In addition, the ratio (% by weight) in a tablet is shown below.

[0053] Element

[0054] Rifaximin

preparation Embodiment 2

[0055] Preparation Example 2 (Tablet)

[0056] Tablets were obtained according to the usual manner described in the Japanese Pharmacopoeia using the following ingredients. In addition, the ratio (% by weight) in a tablet is shown below.

[0057] Element

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PUM

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Abstract

The invention discloses a medicament for treating functional gastrointestinal disorders. The medicament comprises rifamycin B diacetyl amide and rifaximin. The functional gastrointestinal disorders include functional esophageal disorder, functional gastroduodenal disorder, functional intestinal disorder, functional abdominal pain syndrome, functional gallbladder and oddi sphincter disorder, functional anorectal disorder, functional disorder of newborn infants and functional disorder of children and teenagers.

Description

technical field [0001] The present invention relates to a preventive and / or therapeutic agent, in particular to a drug for treating functional gastrointestinal disorders. Background technique [0002] Symptoms such as diarrhea, constipation and abdominal pain are observed in diseases of the gastrointestinal tract with various organic changes, such as gastrointestinal infections and tumors. On the other hand, this symptom can also be observed in many diseases in which organic abnormalities cannot be recognized by endoscopy or examination using a contrast agent. As for diseases exhibiting these symptoms, overall diagnostic criteria have been established, and in 2006, Rome III criteria, which are the latest diagnostic criteria, have been announced, which classify diseases with particular emphasis on the site of exhibiting symptoms. According to these diagnostic criteria patients were classified into different diseases and received necessary medical treatment. [0003] In addi...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P1/00A61P1/16A61P29/00A61P1/14A61P1/12A61P1/10A61K31/395
Inventor 李飞
Owner WUXI CHENGBO SCI & TECH DEV
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