Polygonum aviculare ethyl acetate extract and preparation method and application

Abstract

The invention discloses a preparation method of polygonum aviculare ethyl acetate extract, which comprises the following steps: (1) selecting dry polygonum aviculare stems and leaves and grinding same into powder; (2) soaking the powder with ethyl alcohol, heating, performing reflux extraction, and collecting an extracting solution, and drying by distillation so as to obtain extract; (3) dissolving the extract with water, extracting with petroleum ether, collecting extract liquor at the upper layer petroleum ether part and a solution at the water part respectively, and drying the extract liquor at the upper layer petroleum ether part by distillation so as to prepare polygonum aviculare petroleum ether extract; (4) extracting the solution at the water part with ethyl acetate, collecting upper layer extract liquor and lower part aqueous phase respectively, and drying the upper layer extract liquor so as to obtain polygonum aviculare ethyl acetate extract; (5) continuously extracting the lower part aqueous phase with n-butyl alcohol, and collecting extract liquor, and drying by distillation so as to obtain extract, namely polygonum aviculare n-butyl alcohol extract. The polygonum aviculare ethyl acetate extract has the effects of effectively relaxing smooth muscle of trachea, and is expected to be used for relieving airway obstruction of asthma patients.

Description

technical field [0001] The invention provides an extract of ethyl acetate from agaricus, which is used for preparing a medicine for preventing or treating bronchial asthma, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Bronchial asthma (hereinafter referred to as "asthma") is a common multiple chronic respiratory disease, and its pathogenesis is not yet fully understood. At present, there are at least 300 million people in the world, and there are nearly 30 million asthma patients in my country. Asthma has become the second leading cause of death and disability in the world after cancer. In my country, the incidence of asthma is also increasing year by year. The survey data of the three cities of Beijing, Chongqing, and Guangzhou in 2010 showed that the prevalence rates of childhood asthma were 3.15%, 7.45%, and 2.09%, respectively, compared with 2.69%, 4.63%, and 1.33% 10 years ago. significantly increased. At present, ...

AI Technical Summary

Problems solved by technology

At present, bronchodilators such as β2-receptor agonists are widely used clinically, but the therapeutic effect is limited. The lung function of 30-45% of asthmatic patients cannot be improved. Severe cases require hospitalization

This has caused great pain to the patients themselves and their families, and also increased the burden and loss of social economy.

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