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A method of preparing stainless steel with antibacterial and anticancer properties

A stainless steel, performance technology, applied in metal material coating process, coating, etc., can solve the problems of poor water solubility, patient danger, environmental pollution, etc., and achieve the effect of low cost, good anti-cancer ability, and easy availability of raw materials

Active Publication Date: 2019-07-09
重庆巨源不锈钢制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of curcumin derivatives is poor. If curcumin derivatives are directly introduced into the surface of stainless steel, more organic solvents need to be used, which will pollute the environment, and there may be solvent residues on the titanium metal, which will cause danger to patients.

Method used

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  • A method of preparing stainless steel with antibacterial and anticancer properties
  • A method of preparing stainless steel with antibacterial and anticancer properties
  • A method of preparing stainless steel with antibacterial and anticancer properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] This scheme prepares the method for the stainless steel with antibacterial and anticancer performance, comprises the following steps:

[0024] 1) Dissolve 4 parts by weight of 4-biphenylformaldehyde in 8 parts by weight of ethyl acetate, add 3 parts by weight of benzyl chloride, control 65 ° C, and stir for 2 hours to obtain a compound with formula (1), which is p( 4-phenylbenzyloxy)benzaldehyde;

[0025]

[0026] 2) Dissolve 3 parts by weight of p-(4-phenylbenzyloxy)benzaldehyde and 4 parts by weight of tributyl borate in 10 parts by weight of ethyl acetate, stir at room temperature for 5 minutes, then add 1 part by weight of acetylacetone and boron oxide 0.5 parts by weight of the mixed solution, continue to stir at room temperature for 30 minutes, then add 1 part by weight of n-butylamine, continue to stir for 3 hours, then stop stirring and let it stand for 15 hours, then add 10 parts by weight of hydrochloric acid with a concentration of 0.4mol / L, and stir at 60...

Embodiment 2

[0032] This scheme prepares the method for the stainless steel with antibacterial and anticancer performance, comprises the following steps:

[0033] 1) Dissolve 3 parts by weight of 4-biphenylformaldehyde in 6 parts by weight of ethyl acetate, add 2 parts by weight of benzyl chloride, control 60 ° C, stir and react for 2 hours, and obtain a compound with formula (1), which is para( 4-phenylbenzyloxy)benzaldehyde;

[0034]

[0035] 2) Dissolve 2 parts by weight of p-(4-phenylbenzyloxy)benzaldehyde and 2 parts by weight of tributyl borate in 5 parts by weight of ethyl acetate, stir at room temperature for 4 minutes, then add 0.5 parts by weight of acetylacetone and boron oxide 0.3 parts by weight of the mixed solution, continue to stir at room temperature for 20 minutes, then add 0.5 parts by weight of n-butylamine, continue to stir for 2 hours, then stop stirring and let it stand for 12 hours, then add 6 parts by weight of hydrochloric acid with a concentration of 0.3mol / L,...

Embodiment 3

[0041] This scheme prepares the method for the stainless steel with antibacterial and anticancer performance, comprises the following steps:

[0042] 1) Dissolve 8 parts by weight of 4-biphenyl formaldehyde in 15 parts by weight of ethyl acetate, add 5 parts by weight of benzyl chloride, control 80 ° C, stir and react for 3 hours, and obtain a compound with formula (1), which is para( 4-phenylbenzyloxy)benzaldehyde;

[0043]

[0044] 2) Dissolve 6 parts by weight of p-(4-phenylbenzyloxy)benzaldehyde and 8 parts by weight of tributyl borate in 15 parts by weight of ethyl acetate, stir at room temperature for 6 minutes, then add 1.5 parts by weight of acetylacetone and boron oxide 1.2 parts by weight of the mixed solution, continue to stir at room temperature for 40 minutes, then add 2 parts by weight of n-butylamine, continue to stir for 4 hours, then stop stirring and let stand for 18 hours, then add 15 parts by weight of hydrochloric acid with a concentration of 0.5mol / L, ...

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Abstract

The invention discloses a method for preparing stainless steel with antibiosis and anticancer performance. The method includes the following steps that firstly, a curcumin derivative is prepared; secondly, 0.1-0.6 weight part of cyclodextrin is dissolved into 3.5-20 weight parts of water, after even stirring is conducted, 0.5-1.5 weight parts of stainless steel is added, and soaking is conducted for 20-60 min; thirdly, 0.2-1.2 weight parts of curcumin derivative is added, and 15-30 kHz ultrasonic waves are used for treatment for 30-60 min; and fourthly, the stainless steel is taken out and dried. According to the method, due to the action of the cyclodextrin and the curcumin derivative on the stainless steel, the stainless steel has good antibiosis and anticancer performance, growth of bone cells is facilitated on the surface of the stainless steel, the morbidity of complications in an osseointegration operation of the stainless steel is reduced, and safer and more reliable materials are provided for the osseointegration operation.

Description

technical field [0001] The invention relates to the technical field of materials for osseointegration surgery, more specifically a method for preparing stainless steel with antibacterial and anticancer properties. Background technique [0002] γ-cyclodextrin is a kind of macrocyclic compound formed by connecting 8 D-glucopyranose units end-to-end through α-1,4 glycosidic bonds. Inside the molecule is a "V"-shaped hydrophobic cavity, showing a unique molecular recognition ability. As a commonly used material in osseointegration surgery, stainless steel is widely used clinically. However, a serious problem is the associated bacterial infection problem, which leads to the failure of a large number of transplant operations. Recently, researchers have focused on improving the antibacterial and other capabilities of stainless steel. How to obtain stainless steel materials with better properties has become a research direction with great scientific and application significance. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C26/00
CPCC23C26/00
Inventor 李培源苏炜霍丽妮陈睿
Owner 重庆巨源不锈钢制品有限公司
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